| Full name: myosin heavy chain 3 | Alias Symbol: MYHC-EMB|MYHSE1|HEMHC|SMHCE | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 4621 | HGNC ID: HGNC:7573 | Ensembl Gene: ENSG00000109063 | OMIM ID: 160720 |
| Drug and gene relationship at DGIdb | |||
MYH3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of MYH3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYH3 | 4621 | 205940_at | -0.0817 | 0.8690 | |
| GSE20347 | MYH3 | 4621 | 205940_at | 0.0046 | 0.9541 | |
| GSE23400 | MYH3 | 4621 | 205940_at | 0.0181 | 0.5218 | |
| GSE26886 | MYH3 | 4621 | 205940_at | 0.2692 | 0.1101 | |
| GSE29001 | MYH3 | 4621 | 205940_at | 0.1023 | 0.7092 | |
| GSE38129 | MYH3 | 4621 | 205940_at | -0.0530 | 0.7148 | |
| GSE45670 | MYH3 | 4621 | 205940_at | -0.1293 | 0.3961 | |
| GSE53622 | MYH3 | 4621 | 134642 | 0.2393 | 0.0589 | |
| GSE53624 | MYH3 | 4621 | 134642 | -0.0043 | 0.9685 | |
| GSE63941 | MYH3 | 4621 | 205940_at | 0.0474 | 0.8170 | |
| GSE77861 | MYH3 | 4621 | 205940_at | -0.0158 | 0.9286 | |
| GSE97050 | MYH3 | 4621 | A_23_P26865 | -0.1570 | 0.5179 | |
| SRP064894 | MYH3 | 4621 | RNAseq | 1.1044 | 0.0030 | |
| SRP133303 | MYH3 | 4621 | RNAseq | -0.4432 | 0.0091 | |
| SRP193095 | MYH3 | 4621 | RNAseq | 0.3794 | 0.0943 | |
| SRP219564 | MYH3 | 4621 | RNAseq | 0.3139 | 0.5359 | |
| TCGA | MYH3 | 4621 | RNAseq | -0.4468 | 0.0635 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MYH3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYH3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYH3 | 4621 | 2 | 4 | 24 | |
| GSE20123 | MYH3 | 4621 | 2 | 5 | 23 | |
| GSE43470 | MYH3 | 4621 | 2 | 5 | 36 | |
| GSE46452 | MYH3 | 4621 | 34 | 1 | 24 | |
| GSE47630 | MYH3 | 4621 | 7 | 1 | 32 | |
| GSE54993 | MYH3 | 4621 | 3 | 4 | 63 | |
| GSE54994 | MYH3 | 4621 | 5 | 7 | 41 | |
| GSE60625 | MYH3 | 4621 | 4 | 0 | 7 | |
| GSE74703 | MYH3 | 4621 | 2 | 3 | 31 | |
| GSE74704 | MYH3 | 4621 | 1 | 2 | 17 | |
| TCGA | MYH3 | 4621 | 18 | 20 | 58 |
Total number of gains: 80; Total number of losses: 52; Total Number of normals: 356.
Somatic mutations of MYH3:
Generating mutation plots.
Highly correlated genes for MYH3:
Showing top 20/167 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYH3 | AKAP17A | 0.789886 | 3 | 0 | 3 |
| MYH3 | C8orf44 | 0.78134 | 3 | 0 | 3 |
| MYH3 | ZNF609 | 0.766556 | 3 | 0 | 3 |
| MYH3 | FRYL | 0.754244 | 3 | 0 | 3 |
| MYH3 | TCEAL4 | 0.751907 | 3 | 0 | 3 |
| MYH3 | ZFAND3 | 0.750176 | 3 | 0 | 3 |
| MYH3 | RABGAP1 | 0.742712 | 3 | 0 | 3 |
| MYH3 | ZNF791 | 0.741109 | 3 | 0 | 3 |
| MYH3 | HERC4 | 0.731902 | 3 | 0 | 3 |
| MYH3 | SLC25A28 | 0.731595 | 3 | 0 | 3 |
| MYH3 | METTL3 | 0.730777 | 3 | 0 | 3 |
| MYH3 | TTF1 | 0.72485 | 3 | 0 | 3 |
| MYH3 | SP100 | 0.724632 | 3 | 0 | 3 |
| MYH3 | DMAP1 | 0.721848 | 3 | 0 | 3 |
| MYH3 | MAN2B2 | 0.719377 | 3 | 0 | 3 |
| MYH3 | IFIT5 | 0.717022 | 3 | 0 | 3 |
| MYH3 | ANKRD11 | 0.713996 | 3 | 0 | 3 |
| MYH3 | MRPS21 | 0.712051 | 3 | 0 | 3 |
| MYH3 | SLC25A27 | 0.710369 | 3 | 0 | 3 |
| MYH3 | WDR1 | 0.709608 | 3 | 0 | 3 |
For details and further investigation, click here
