CREB3L4

 

Full name: cAMP responsive element binding protein 3 like 4 Alias Symbol: AIbZIP|CREB4|CREB3|hJAL|ATCE1
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 148327 HGNC ID: HGNC:18854 Ensembl Gene: ENSG00000143578 OMIM ID: 607138
Drug and gene relationship at DGIdb

 

CREB3L4 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04668TNF signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04911Insulin secretion
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04922Glucagon signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04931Insulin resistance
hsa04962Vasopressin-regulated water reabsorption
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05161Hepatitis B
hsa05215Prostate cancer

 

Expression of CREB3L4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CREB3L4 148327 226455_at -0.4952 0.1999
GSE26886 CREB3L4 148327 226455_at 0.6434 0.0033
GSE45670 CREB3L4 148327 226455_at -0.3845 0.0605
GSE53622 CREB3L4 148327 11076 -0.1975 0.0003
GSE53624 CREB3L4 148327 11076 -0.2714 0.0000
GSE63941 CREB3L4 148327 226455_at 1.3994 0.0218
GSE77861 CREB3L4 148327 226455_at -0.0051 0.9836
GSE97050 CREB3L4 148327 A_33_P3345708 -0.0967 0.7086
SRP007169 CREB3L4 148327 RNAseq -0.7784 0.1767
SRP064894 CREB3L4 148327 RNAseq -0.6174 0.0676
SRP133303 CREB3L4 148327 RNAseq -0.8956 0.0035
SRP159526 CREB3L4 148327 RNAseq 0.7305 0.0626
SRP193095 CREB3L4 148327 RNAseq -0.3567 0.0483
SRP219564 CREB3L4 148327 RNAseq -0.4094 0.4275
TCGA CREB3L4 148327 RNAseq -0.2652 0.0148

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by CREB3L4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CREB3L4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CREB3L4 148327 14 0 16
GSE20123 CREB3L4 148327 14 0 16
GSE43470 CREB3L4 148327 7 2 34
GSE46452 CREB3L4 148327 2 1 56
GSE47630 CREB3L4 148327 14 0 26
GSE54993 CREB3L4 148327 0 4 66
GSE54994 CREB3L4 148327 16 0 37
GSE60625 CREB3L4 148327 0 0 11
GSE74703 CREB3L4 148327 6 1 29
GSE74704 CREB3L4 148327 7 0 13
TCGA CREB3L4 148327 38 2 56

Total number of gains: 118; Total number of losses: 10; Total Number of normals: 360.  

 

Somatic mutations of CREB3L4:

 

Generating mutation plots.

 

Highly correlated genes for CREB3L4:

 

Showing top 20/55 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CREB3L4ETV20.732415303
CREB3L4ABCD20.669841303
CREB3L4FZD30.65621303
CREB3L4ZNF7040.643061504
CREB3L4BEND50.641804303
CREB3L4SALL20.638149404
CREB3L4RPS6KA50.629881303
CREB3L4STON10.627925403
CREB3L4RILP0.620478303
CREB3L4SEMA6C0.618696504
CREB3L4ACTA10.610749303
CREB3L4RPS270.606746403
CREB3L4FXYD10.606514303
CREB3L4DCAKD0.601521303
CREB3L4ZBED30.58977504
CREB3L4APOLD10.588515404
CREB3L4ANK30.58544403
CREB3L4XPC0.576724403
CREB3L4RAD51-AS10.576441303
CREB3L4PDE8B0.571396403

For details and further investigation, click here