| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 10 | Alias Symbol: ADAM-TS10 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 81794 | HGNC ID: HGNC:13201 | Ensembl Gene: ENSG00000142303 | OMIM ID: 608990 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS10 | 81794 | 230341_x_at | -0.2762 | 0.1553 | |
| GSE26886 | ADAMTS10 | 81794 | 230341_x_at | 0.4664 | 0.0204 | |
| GSE45670 | ADAMTS10 | 81794 | 230341_x_at | -0.1908 | 0.1003 | |
| GSE53622 | ADAMTS10 | 81794 | 34493 | 0.0183 | 0.8332 | |
| GSE53624 | ADAMTS10 | 81794 | 34493 | 0.2490 | 0.0013 | |
| GSE63941 | ADAMTS10 | 81794 | 230341_x_at | 0.4526 | 0.0045 | |
| GSE77861 | ADAMTS10 | 81794 | 230341_x_at | -0.0985 | 0.6659 | |
| GSE97050 | ADAMTS10 | 81794 | A_33_P3223056 | 0.0931 | 0.6712 | |
| SRP064894 | ADAMTS10 | 81794 | RNAseq | 0.6132 | 0.0508 | |
| SRP133303 | ADAMTS10 | 81794 | RNAseq | -0.2704 | 0.2972 | |
| SRP159526 | ADAMTS10 | 81794 | RNAseq | -0.2338 | 0.6344 | |
| SRP193095 | ADAMTS10 | 81794 | RNAseq | 1.1633 | 0.0000 | |
| SRP219564 | ADAMTS10 | 81794 | RNAseq | 1.0512 | 0.1229 | |
| TCGA | ADAMTS10 | 81794 | RNAseq | -0.1956 | 0.2188 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ADAMTS10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS10 | 81794 | 4 | 3 | 23 | |
| GSE20123 | ADAMTS10 | 81794 | 3 | 2 | 25 | |
| GSE43470 | ADAMTS10 | 81794 | 2 | 6 | 35 | |
| GSE46452 | ADAMTS10 | 81794 | 47 | 1 | 11 | |
| GSE47630 | ADAMTS10 | 81794 | 5 | 7 | 28 | |
| GSE54993 | ADAMTS10 | 81794 | 16 | 2 | 52 | |
| GSE54994 | ADAMTS10 | 81794 | 6 | 14 | 33 | |
| GSE60625 | ADAMTS10 | 81794 | 9 | 0 | 2 | |
| GSE74703 | ADAMTS10 | 81794 | 2 | 4 | 30 | |
| GSE74704 | ADAMTS10 | 81794 | 0 | 2 | 18 | |
| TCGA | ADAMTS10 | 81794 | 10 | 19 | 67 |
Total number of gains: 104; Total number of losses: 60; Total Number of normals: 324.
Somatic mutations of ADAMTS10:
Generating mutation plots.
Highly correlated genes for ADAMTS10:
Showing top 20/253 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS10 | ACY1 | 0.792696 | 3 | 0 | 3 |
| ADAMTS10 | SPTAN1 | 0.758407 | 3 | 0 | 3 |
| ADAMTS10 | JUNB | 0.755595 | 3 | 0 | 3 |
| ADAMTS10 | NFAM1 | 0.743111 | 3 | 0 | 3 |
| ADAMTS10 | ZFYVE9 | 0.73426 | 3 | 0 | 3 |
| ADAMTS10 | TRAPPC1 | 0.730443 | 3 | 0 | 3 |
| ADAMTS10 | NLRP12 | 0.728278 | 3 | 0 | 3 |
| ADAMTS10 | EXTL1 | 0.715244 | 3 | 0 | 3 |
| ADAMTS10 | NT5M | 0.712406 | 4 | 0 | 4 |
| ADAMTS10 | SUGP1 | 0.708837 | 3 | 0 | 3 |
| ADAMTS10 | TMEM255B | 0.701562 | 3 | 0 | 3 |
| ADAMTS10 | SIK1 | 0.700784 | 5 | 0 | 5 |
| ADAMTS10 | KIAA0895L | 0.698122 | 3 | 0 | 3 |
| ADAMTS10 | COPE | 0.698089 | 3 | 0 | 3 |
| ADAMTS10 | KLF16 | 0.695019 | 5 | 0 | 5 |
| ADAMTS10 | KCNK2 | 0.694823 | 3 | 0 | 3 |
| ADAMTS10 | SELPLG | 0.694416 | 5 | 0 | 4 |
| ADAMTS10 | KDM5C | 0.69353 | 3 | 0 | 3 |
| ADAMTS10 | SEC31B | 0.691951 | 3 | 0 | 3 |
| ADAMTS10 | PCGF2 | 0.691442 | 4 | 0 | 3 |
For details and further investigation, click here
