| Full name: actinin alpha 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q43 | ||
| Entrez ID: 88 | HGNC ID: HGNC:164 | Ensembl Gene: ENSG00000077522 | OMIM ID: 102573 |
| Drug and gene relationship at DGIdb | |||
ACTN2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04510 | Focal adhesion | |
| hsa04520 | Adherens junction | |
| hsa04530 | Tight junction | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ACTN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACTN2 | 88 | 203861_s_at | -0.1461 | 0.8218 | |
| GSE20347 | ACTN2 | 88 | 203861_s_at | 0.1407 | 0.1108 | |
| GSE23400 | ACTN2 | 88 | 203861_s_at | -0.1776 | 0.0245 | |
| GSE26886 | ACTN2 | 88 | 203861_s_at | 0.0554 | 0.7301 | |
| GSE29001 | ACTN2 | 88 | 203864_s_at | -0.1554 | 0.4592 | |
| GSE38129 | ACTN2 | 88 | 203861_s_at | -0.4748 | 0.0669 | |
| GSE45670 | ACTN2 | 88 | 203861_s_at | -0.0341 | 0.8904 | |
| GSE53622 | ACTN2 | 88 | 13062 | -0.4369 | 0.1304 | |
| GSE53624 | ACTN2 | 88 | 13062 | -0.2859 | 0.0471 | |
| GSE63941 | ACTN2 | 88 | 203861_s_at | 0.2732 | 0.0918 | |
| GSE77861 | ACTN2 | 88 | 203864_s_at | -0.1700 | 0.1177 | |
| GSE97050 | ACTN2 | 88 | A_33_P3212167 | -1.2981 | 0.1856 | |
| TCGA | ACTN2 | 88 | RNAseq | -1.7527 | 0.0099 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ACTN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACTN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACTN2 | 88 | 11 | 0 | 19 | |
| GSE20123 | ACTN2 | 88 | 12 | 0 | 18 | |
| GSE43470 | ACTN2 | 88 | 8 | 1 | 34 | |
| GSE46452 | ACTN2 | 88 | 4 | 2 | 53 | |
| GSE47630 | ACTN2 | 88 | 15 | 0 | 25 | |
| GSE54993 | ACTN2 | 88 | 0 | 6 | 64 | |
| GSE54994 | ACTN2 | 88 | 16 | 0 | 37 | |
| GSE60625 | ACTN2 | 88 | 0 | 0 | 11 | |
| GSE74703 | ACTN2 | 88 | 8 | 1 | 27 | |
| GSE74704 | ACTN2 | 88 | 5 | 0 | 15 | |
| TCGA | ACTN2 | 88 | 43 | 4 | 49 |
Total number of gains: 122; Total number of losses: 14; Total Number of normals: 352.
Somatic mutations of ACTN2:
Generating mutation plots.
Highly correlated genes for ACTN2:
Showing top 20/398 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACTN2 | KATNAL1 | 0.728811 | 3 | 0 | 3 |
| ACTN2 | NYX | 0.716411 | 3 | 0 | 3 |
| ACTN2 | GLP2R | 0.713982 | 4 | 0 | 4 |
| ACTN2 | TMOD1 | 0.709485 | 6 | 0 | 6 |
| ACTN2 | OLAH | 0.707374 | 3 | 0 | 3 |
| ACTN2 | KBTBD12 | 0.704553 | 3 | 0 | 3 |
| ACTN2 | CASQ1 | 0.702838 | 8 | 0 | 7 |
| ACTN2 | FRRS1L | 0.699061 | 5 | 0 | 5 |
| ACTN2 | RASD2 | 0.697499 | 3 | 0 | 3 |
| ACTN2 | VGLL1 | 0.687704 | 3 | 0 | 3 |
| ACTN2 | ESRRG | 0.687609 | 5 | 0 | 4 |
| ACTN2 | NRXN3 | 0.681666 | 6 | 0 | 5 |
| ACTN2 | HTR3B | 0.680824 | 3 | 0 | 3 |
| ACTN2 | TRH | 0.679653 | 3 | 0 | 3 |
| ACTN2 | HDAC11 | 0.679352 | 3 | 0 | 3 |
| ACTN2 | SSTR4 | 0.679089 | 3 | 0 | 3 |
| ACTN2 | NPY | 0.675046 | 8 | 0 | 7 |
| ACTN2 | LINC01278 | 0.672826 | 4 | 0 | 4 |
| ACTN2 | ZMAT4 | 0.672423 | 6 | 0 | 4 |
| ACTN2 | TUBB4A | 0.669887 | 3 | 0 | 3 |
For details and further investigation, click here
