| Full name: neuropeptide Y | Alias Symbol: PYY4 | ||
| Type: protein-coding gene | Cytoband: 7p15.3 | ||
| Entrez ID: 4852 | HGNC ID: HGNC:7955 | Ensembl Gene: ENSG00000122585 | OMIM ID: 162640 |
| Drug and gene relationship at DGIdb | |||
NPY involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04024 | cAMP signaling pathway | |
| hsa04920 | Adipocytokine signaling pathway | |
| hsa04923 | Regulation of lipolysis in adipocytes | |
| hsa05034 | Alcoholism |
Expression of NPY:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPY | 4852 | 206001_at | -0.4048 | 0.7422 | |
| GSE20347 | NPY | 4852 | 206001_at | -0.2188 | 0.0938 | |
| GSE23400 | NPY | 4852 | 206001_at | -0.2225 | 0.0001 | |
| GSE26886 | NPY | 4852 | 206001_at | 0.0369 | 0.7710 | |
| GSE29001 | NPY | 4852 | 206001_at | -0.1751 | 0.1974 | |
| GSE38129 | NPY | 4852 | 206001_at | -0.7032 | 0.0173 | |
| GSE45670 | NPY | 4852 | 206001_at | -0.0519 | 0.5827 | |
| GSE53622 | NPY | 4852 | 16401 | -0.0713 | 0.8025 | |
| GSE53624 | NPY | 4852 | 16401 | 0.5507 | 0.0001 | |
| GSE63941 | NPY | 4852 | 206001_at | -0.0760 | 0.6442 | |
| GSE77861 | NPY | 4852 | 206001_at | -0.1171 | 0.2060 | |
| GSE97050 | NPY | 4852 | A_23_P256470 | -0.7888 | 0.2268 | |
| TCGA | NPY | 4852 | RNAseq | -3.0154 | 0.0200 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NPY expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPY:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPY | 4852 | 17 | 1 | 12 | |
| GSE20123 | NPY | 4852 | 17 | 1 | 12 | |
| GSE43470 | NPY | 4852 | 4 | 0 | 39 | |
| GSE46452 | NPY | 4852 | 10 | 2 | 47 | |
| GSE47630 | NPY | 4852 | 9 | 1 | 30 | |
| GSE54993 | NPY | 4852 | 0 | 6 | 64 | |
| GSE54994 | NPY | 4852 | 20 | 2 | 31 | |
| GSE60625 | NPY | 4852 | 0 | 0 | 11 | |
| GSE74703 | NPY | 4852 | 4 | 0 | 32 | |
| GSE74704 | NPY | 4852 | 11 | 1 | 8 | |
| TCGA | NPY | 4852 | 56 | 5 | 35 |
Total number of gains: 148; Total number of losses: 19; Total Number of normals: 321.
Somatic mutations of NPY:
Generating mutation plots.
Highly correlated genes for NPY:
Showing top 20/524 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPY | KBTBD12 | 0.813161 | 3 | 0 | 3 |
| NPY | C9orf24 | 0.795775 | 3 | 0 | 3 |
| NPY | CACNA1H | 0.785637 | 6 | 0 | 6 |
| NPY | TMOD1 | 0.767856 | 4 | 0 | 4 |
| NPY | MYOM1 | 0.754685 | 6 | 0 | 5 |
| NPY | SLC25A4 | 0.74353 | 6 | 0 | 6 |
| NPY | NT5DC3 | 0.736681 | 5 | 0 | 5 |
| NPY | PRKG2 | 0.735785 | 3 | 0 | 3 |
| NPY | LRRTM1 | 0.733504 | 3 | 0 | 3 |
| NPY | STMN2 | 0.732317 | 9 | 0 | 8 |
| NPY | PYGM | 0.72787 | 6 | 0 | 5 |
| NPY | HECTD2 | 0.727746 | 3 | 0 | 3 |
| NPY | VIP | 0.727414 | 10 | 0 | 8 |
| NPY | ARHGAP36 | 0.722515 | 3 | 0 | 3 |
| NPY | MYOT | 0.718676 | 6 | 0 | 5 |
| NPY | SGCA | 0.705989 | 6 | 0 | 6 |
| NPY | AGTR2 | 0.705194 | 3 | 0 | 3 |
| NPY | HSPB7 | 0.704701 | 6 | 0 | 5 |
| NPY | PRRT2 | 0.70101 | 3 | 0 | 3 |
| NPY | SPOP | 0.699004 | 4 | 0 | 4 |
For details and further investigation, click here
