| Full name: 5-hydroxytryptamine receptor 3B | Alias Symbol: 5-HT3B | ||
| Type: protein-coding gene | Cytoband: 11q23.2 | ||
| Entrez ID: 9177 | HGNC ID: HGNC:5298 | Ensembl Gene: ENSG00000149305 | OMIM ID: 604654 |
| Drug and gene relationship at DGIdb | |||
HTR3B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04726 | Serotonergic synapse | |
| hsa04742 | Taste transduction |
Expression of HTR3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR3B | 9177 | 221084_at | -0.3447 | 0.0764 | |
| GSE20347 | HTR3B | 9177 | 221084_at | -0.1805 | 0.0092 | |
| GSE23400 | HTR3B | 9177 | 221084_at | -0.2572 | 0.0000 | |
| GSE26886 | HTR3B | 9177 | 221084_at | -0.4983 | 0.0004 | |
| GSE29001 | HTR3B | 9177 | 221084_at | -0.3238 | 0.0286 | |
| GSE38129 | HTR3B | 9177 | 221084_at | -0.3435 | 0.0001 | |
| GSE45670 | HTR3B | 9177 | 221084_at | -0.2933 | 0.0279 | |
| GSE53622 | HTR3B | 9177 | 36740 | -2.6105 | 0.0000 | |
| GSE53624 | HTR3B | 9177 | 36740 | -3.0373 | 0.0000 | |
| GSE63941 | HTR3B | 9177 | 221084_at | 0.1835 | 0.2108 | |
| GSE77861 | HTR3B | 9177 | 221084_at | -0.2732 | 0.0424 | |
| SRP064894 | HTR3B | 9177 | RNAseq | -0.4866 | 0.1144 | |
| SRP133303 | HTR3B | 9177 | RNAseq | -0.0021 | 0.9889 | |
| SRP159526 | HTR3B | 9177 | RNAseq | -0.7052 | 0.1235 | |
| SRP193095 | HTR3B | 9177 | RNAseq | -0.0711 | 0.6659 | |
| SRP219564 | HTR3B | 9177 | RNAseq | -1.1686 | 0.0129 | |
| TCGA | HTR3B | 9177 | RNAseq | -1.8363 | 0.2232 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by HTR3B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR3B | 9177 | 0 | 13 | 17 | |
| GSE20123 | HTR3B | 9177 | 0 | 13 | 17 | |
| GSE43470 | HTR3B | 9177 | 2 | 7 | 34 | |
| GSE46452 | HTR3B | 9177 | 3 | 26 | 30 | |
| GSE47630 | HTR3B | 9177 | 2 | 19 | 19 | |
| GSE54993 | HTR3B | 9177 | 10 | 0 | 60 | |
| GSE54994 | HTR3B | 9177 | 5 | 19 | 29 | |
| GSE60625 | HTR3B | 9177 | 0 | 3 | 8 | |
| GSE74703 | HTR3B | 9177 | 1 | 5 | 30 | |
| GSE74704 | HTR3B | 9177 | 0 | 9 | 11 | |
| TCGA | HTR3B | 9177 | 5 | 49 | 42 |
Total number of gains: 28; Total number of losses: 163; Total Number of normals: 297.
Somatic mutations of HTR3B:
Generating mutation plots.
Highly correlated genes for HTR3B:
Showing top 20/1621 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR3B | LINC00330 | 0.77176 | 5 | 0 | 5 |
| HTR3B | MORN3 | 0.771041 | 3 | 0 | 3 |
| HTR3B | IQCF1 | 0.769445 | 3 | 0 | 3 |
| HTR3B | ASPG | 0.767349 | 5 | 0 | 5 |
| HTR3B | SLC46A2 | 0.762678 | 6 | 0 | 6 |
| HTR3B | VSIG10L | 0.758351 | 6 | 0 | 6 |
| HTR3B | A2ML1 | 0.7541 | 6 | 0 | 5 |
| HTR3B | TEAD3 | 0.753515 | 3 | 0 | 3 |
| HTR3B | PRSS27 | 0.743016 | 6 | 0 | 6 |
| HTR3B | SH3BGRL2 | 0.741931 | 6 | 0 | 6 |
| HTR3B | FAM3D | 0.740598 | 6 | 0 | 6 |
| HTR3B | BNIPL | 0.735725 | 6 | 0 | 6 |
| HTR3B | ULK3 | 0.729734 | 6 | 0 | 6 |
| HTR3B | PHYHD1 | 0.728511 | 6 | 0 | 6 |
| HTR3B | HCG22 | 0.724783 | 7 | 0 | 6 |
| HTR3B | AMER2 | 0.723315 | 3 | 0 | 3 |
| HTR3B | CAPNS2 | 0.720518 | 3 | 0 | 3 |
| HTR3B | KRT32 | 0.717078 | 10 | 0 | 10 |
| HTR3B | PAQR8 | 0.716417 | 6 | 0 | 6 |
| HTR3B | ATP13A4 | 0.716123 | 6 | 0 | 6 |
For details and further investigation, click here
