| Full name: actin related protein 1A | Alias Symbol: ARP1|Arp1A | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 10121 | HGNC ID: HGNC:167 | Ensembl Gene: ENSG00000138107 | OMIM ID: 605143 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ACTR1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACTR1A | 10121 | 200720_s_at | -0.3910 | 0.3373 | |
| GSE20347 | ACTR1A | 10121 | 200721_s_at | -0.4922 | 0.0001 | |
| GSE23400 | ACTR1A | 10121 | 200721_s_at | -0.2269 | 0.0001 | |
| GSE26886 | ACTR1A | 10121 | 200721_s_at | -0.5083 | 0.0205 | |
| GSE29001 | ACTR1A | 10121 | 200721_s_at | -0.4388 | 0.0053 | |
| GSE38129 | ACTR1A | 10121 | 200721_s_at | -0.4548 | 0.0002 | |
| GSE45670 | ACTR1A | 10121 | 200720_s_at | -0.3542 | 0.0480 | |
| GSE53622 | ACTR1A | 10121 | 13658 | -0.3070 | 0.0000 | |
| GSE53624 | ACTR1A | 10121 | 13658 | -0.1401 | 0.0022 | |
| GSE63941 | ACTR1A | 10121 | 200720_s_at | -0.1477 | 0.7455 | |
| GSE77861 | ACTR1A | 10121 | 200720_s_at | -0.7809 | 0.0286 | |
| GSE97050 | ACTR1A | 10121 | A_24_P278367 | -0.2216 | 0.3038 | |
| SRP007169 | ACTR1A | 10121 | RNAseq | -1.3594 | 0.0001 | |
| SRP008496 | ACTR1A | 10121 | RNAseq | -1.0915 | 0.0000 | |
| SRP064894 | ACTR1A | 10121 | RNAseq | -0.1005 | 0.5556 | |
| SRP133303 | ACTR1A | 10121 | RNAseq | -0.0735 | 0.5666 | |
| SRP159526 | ACTR1A | 10121 | RNAseq | -0.5142 | 0.0398 | |
| SRP193095 | ACTR1A | 10121 | RNAseq | -0.1988 | 0.0429 | |
| SRP219564 | ACTR1A | 10121 | RNAseq | -0.4111 | 0.2526 | |
| TCGA | ACTR1A | 10121 | RNAseq | -0.0696 | 0.1220 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ACTR1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACTR1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACTR1A | 10121 | 2 | 9 | 19 | |
| GSE20123 | ACTR1A | 10121 | 2 | 8 | 20 | |
| GSE43470 | ACTR1A | 10121 | 0 | 8 | 35 | |
| GSE46452 | ACTR1A | 10121 | 0 | 11 | 48 | |
| GSE47630 | ACTR1A | 10121 | 2 | 14 | 24 | |
| GSE54993 | ACTR1A | 10121 | 8 | 0 | 62 | |
| GSE54994 | ACTR1A | 10121 | 1 | 11 | 41 | |
| GSE60625 | ACTR1A | 10121 | 0 | 0 | 11 | |
| GSE74703 | ACTR1A | 10121 | 0 | 5 | 31 | |
| GSE74704 | ACTR1A | 10121 | 1 | 4 | 15 | |
| TCGA | ACTR1A | 10121 | 5 | 29 | 62 |
Total number of gains: 21; Total number of losses: 99; Total Number of normals: 368.
Somatic mutations of ACTR1A:
Generating mutation plots.
Highly correlated genes for ACTR1A:
Showing top 20/974 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACTR1A | RHBDD1 | 0.797524 | 3 | 0 | 3 |
| ACTR1A | ICA1L | 0.78814 | 3 | 0 | 3 |
| ACTR1A | LEPROT | 0.777251 | 3 | 0 | 3 |
| ACTR1A | TLE2 | 0.752519 | 3 | 0 | 3 |
| ACTR1A | ARMCX6 | 0.748181 | 3 | 0 | 3 |
| ACTR1A | BRK1 | 0.745937 | 6 | 0 | 6 |
| ACTR1A | SLC25A26 | 0.740821 | 3 | 0 | 3 |
| ACTR1A | ZNF214 | 0.740562 | 4 | 0 | 3 |
| ACTR1A | ERC1 | 0.740487 | 3 | 0 | 3 |
| ACTR1A | PEG3 | 0.736722 | 3 | 0 | 3 |
| ACTR1A | ZNF862 | 0.736096 | 3 | 0 | 3 |
| ACTR1A | NDUFA10 | 0.728523 | 3 | 0 | 3 |
| ACTR1A | OR7E24 | 0.725134 | 3 | 0 | 3 |
| ACTR1A | PPIP5K2 | 0.72278 | 3 | 0 | 3 |
| ACTR1A | EIF2D | 0.722072 | 3 | 0 | 3 |
| ACTR1A | BLOC1S2 | 0.721343 | 3 | 0 | 3 |
| ACTR1A | RBX1 | 0.716634 | 3 | 0 | 3 |
| ACTR1A | ACRBP | 0.716021 | 3 | 0 | 3 |
| ACTR1A | WDR41 | 0.714367 | 3 | 0 | 3 |
| ACTR1A | FBXL3 | 0.707948 | 4 | 0 | 4 |
For details and further investigation, click here
