| Full name: eukaryotic translation initiation factor 2D | Alias Symbol: LGTN | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 1939 | HGNC ID: HGNC:6583 | Ensembl Gene: ENSG00000143486 | OMIM ID: 613709 |
| Drug and gene relationship at DGIdb | |||
Expression of EIF2D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF2D | 1939 | 218253_s_at | -0.2349 | 0.4019 | |
| GSE20347 | EIF2D | 1939 | 218253_s_at | -0.3098 | 0.0167 | |
| GSE23400 | EIF2D | 1939 | 218253_s_at | 0.0831 | 0.1525 | |
| GSE26886 | EIF2D | 1939 | 218253_s_at | 0.6105 | 0.0037 | |
| GSE29001 | EIF2D | 1939 | 218253_s_at | 0.1419 | 0.5735 | |
| GSE38129 | EIF2D | 1939 | 218253_s_at | -0.2203 | 0.0396 | |
| GSE45670 | EIF2D | 1939 | 218253_s_at | -0.2837 | 0.0361 | |
| GSE53622 | EIF2D | 1939 | 48629 | -0.0640 | 0.3130 | |
| GSE53624 | EIF2D | 1939 | 48629 | -0.0895 | 0.1365 | |
| GSE63941 | EIF2D | 1939 | 218253_s_at | 0.0034 | 0.9944 | |
| GSE77861 | EIF2D | 1939 | 218253_s_at | -0.1580 | 0.6280 | |
| GSE97050 | EIF2D | 1939 | A_23_P115346 | -0.0264 | 0.9107 | |
| SRP007169 | EIF2D | 1939 | RNAseq | -0.7035 | 0.0307 | |
| SRP008496 | EIF2D | 1939 | RNAseq | -0.3979 | 0.1754 | |
| SRP064894 | EIF2D | 1939 | RNAseq | -0.1857 | 0.2544 | |
| SRP133303 | EIF2D | 1939 | RNAseq | -0.3734 | 0.0965 | |
| SRP159526 | EIF2D | 1939 | RNAseq | 0.1321 | 0.6576 | |
| SRP193095 | EIF2D | 1939 | RNAseq | -0.3985 | 0.0000 | |
| SRP219564 | EIF2D | 1939 | RNAseq | 0.0040 | 0.9925 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF2D expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of EIF2D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF2D | 1939 | 11 | 0 | 19 | |
| GSE20123 | EIF2D | 1939 | 11 | 0 | 19 | |
| GSE43470 | EIF2D | 1939 | 7 | 0 | 36 | |
| GSE46452 | EIF2D | 1939 | 3 | 1 | 55 | |
| GSE47630 | EIF2D | 1939 | 14 | 0 | 26 | |
| GSE54993 | EIF2D | 1939 | 0 | 6 | 64 | |
| GSE54994 | EIF2D | 1939 | 14 | 0 | 39 | |
| GSE60625 | EIF2D | 1939 | 0 | 0 | 11 | |
| GSE74703 | EIF2D | 1939 | 7 | 0 | 29 | |
| GSE74704 | EIF2D | 1939 | 5 | 0 | 15 | |
| TCGA | EIF2D | 1939 | 44 | 5 | 47 |
Total number of gains: 116; Total number of losses: 12; Total Number of normals: 360.
Somatic mutations of EIF2D:
Generating mutation plots.
Highly correlated genes for EIF2D:
Showing top 20/358 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF2D | UQCRFS1 | 0.816386 | 3 | 0 | 3 |
| EIF2D | RABL3 | 0.80935 | 3 | 0 | 3 |
| EIF2D | TCF7L2 | 0.805361 | 3 | 0 | 3 |
| EIF2D | DMAP1 | 0.789949 | 3 | 0 | 3 |
| EIF2D | SUGT1 | 0.782911 | 3 | 0 | 3 |
| EIF2D | TIMM9 | 0.780865 | 3 | 0 | 3 |
| EIF2D | PPP1R11 | 0.778561 | 4 | 0 | 4 |
| EIF2D | PIN1 | 0.773723 | 3 | 0 | 3 |
| EIF2D | NAP1L1 | 0.768915 | 3 | 0 | 3 |
| EIF2D | FBXL3 | 0.767682 | 3 | 0 | 3 |
| EIF2D | EEF2 | 0.764789 | 3 | 0 | 3 |
| EIF2D | OGT | 0.76007 | 3 | 0 | 3 |
| EIF2D | POLR3GL | 0.757031 | 3 | 0 | 3 |
| EIF2D | RPS21 | 0.756364 | 3 | 0 | 3 |
| EIF2D | KLHL7 | 0.755965 | 3 | 0 | 3 |
| EIF2D | DNAJC27 | 0.739944 | 3 | 0 | 3 |
| EIF2D | SHPRH | 0.739596 | 3 | 0 | 3 |
| EIF2D | ZNF776 | 0.7382 | 3 | 0 | 3 |
| EIF2D | GATC | 0.737945 | 3 | 0 | 3 |
| EIF2D | WHAMM | 0.736233 | 3 | 0 | 3 |
For details and further investigation, click here
