| Full name: biogenesis of lysosomal organelles complex 1 subunit 2 | Alias Symbol: MGC10120|FLJ30135|BLOS2|BORCS2 | ||
| Type: protein-coding gene | Cytoband: 10q24.31 | ||
| Entrez ID: 282991 | HGNC ID: HGNC:20984 | Ensembl Gene: ENSG00000196072 | OMIM ID: 609768 |
| Drug and gene relationship at DGIdb | |||
Expression of BLOC1S2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BLOC1S2 | 282991 | 225049_at | -0.5211 | 0.2694 | |
| GSE26886 | BLOC1S2 | 282991 | 225049_at | -0.5687 | 0.0029 | |
| GSE45670 | BLOC1S2 | 282991 | 225049_at | -0.0233 | 0.8673 | |
| GSE53622 | BLOC1S2 | 282991 | 37075 | -0.3725 | 0.0000 | |
| GSE53624 | BLOC1S2 | 282991 | 37075 | -0.3670 | 0.0000 | |
| GSE63941 | BLOC1S2 | 282991 | 225049_at | -0.4184 | 0.1395 | |
| GSE77861 | BLOC1S2 | 282991 | 225049_at | -0.4688 | 0.1964 | |
| GSE97050 | BLOC1S2 | 282991 | A_24_P295543 | -0.0458 | 0.9281 | |
| SRP007169 | BLOC1S2 | 282991 | RNAseq | -0.7297 | 0.0405 | |
| SRP008496 | BLOC1S2 | 282991 | RNAseq | -0.4949 | 0.0369 | |
| SRP064894 | BLOC1S2 | 282991 | RNAseq | -0.2749 | 0.1235 | |
| SRP133303 | BLOC1S2 | 282991 | RNAseq | -0.0626 | 0.7387 | |
| SRP159526 | BLOC1S2 | 282991 | RNAseq | -0.3082 | 0.4649 | |
| SRP193095 | BLOC1S2 | 282991 | RNAseq | -0.6317 | 0.0001 | |
| SRP219564 | BLOC1S2 | 282991 | RNAseq | -0.4865 | 0.3173 | |
| TCGA | BLOC1S2 | 282991 | RNAseq | 0.1974 | 0.0007 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BLOC1S2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BLOC1S2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BLOC1S2 | 282991 | 1 | 8 | 21 | |
| GSE20123 | BLOC1S2 | 282991 | 1 | 7 | 22 | |
| GSE43470 | BLOC1S2 | 282991 | 0 | 7 | 36 | |
| GSE46452 | BLOC1S2 | 282991 | 0 | 11 | 48 | |
| GSE47630 | BLOC1S2 | 282991 | 2 | 14 | 24 | |
| GSE54993 | BLOC1S2 | 282991 | 8 | 0 | 62 | |
| GSE54994 | BLOC1S2 | 282991 | 1 | 12 | 40 | |
| GSE60625 | BLOC1S2 | 282991 | 0 | 0 | 11 | |
| GSE74703 | BLOC1S2 | 282991 | 0 | 5 | 31 | |
| GSE74704 | BLOC1S2 | 282991 | 0 | 4 | 16 | |
| TCGA | BLOC1S2 | 282991 | 5 | 28 | 63 |
Total number of gains: 18; Total number of losses: 96; Total Number of normals: 374.
Somatic mutations of BLOC1S2:
Generating mutation plots.
Highly correlated genes for BLOC1S2:
Showing top 20/906 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BLOC1S2 | ALG6 | 0.809257 | 3 | 0 | 3 |
| BLOC1S2 | TOM1 | 0.797234 | 4 | 0 | 4 |
| BLOC1S2 | RABGGTA | 0.790849 | 4 | 0 | 4 |
| BLOC1S2 | UGP2 | 0.771233 | 3 | 0 | 3 |
| BLOC1S2 | FAM122A | 0.770235 | 3 | 0 | 3 |
| BLOC1S2 | LAPTM4A | 0.767377 | 3 | 0 | 3 |
| BLOC1S2 | GPR157 | 0.767089 | 3 | 0 | 3 |
| BLOC1S2 | ZMPSTE24 | 0.762031 | 3 | 0 | 3 |
| BLOC1S2 | RHBDF1 | 0.759276 | 3 | 0 | 3 |
| BLOC1S2 | CERS4 | 0.753756 | 3 | 0 | 3 |
| BLOC1S2 | SS18 | 0.752319 | 3 | 0 | 3 |
| BLOC1S2 | ZCCHC9 | 0.751215 | 4 | 0 | 4 |
| BLOC1S2 | KLHL20 | 0.750618 | 3 | 0 | 3 |
| BLOC1S2 | CSDE1 | 0.750513 | 3 | 0 | 3 |
| BLOC1S2 | GTF2B | 0.749909 | 3 | 0 | 3 |
| BLOC1S2 | CCNYL1 | 0.749779 | 4 | 0 | 4 |
| BLOC1S2 | GLUD2 | 0.749305 | 3 | 0 | 3 |
| BLOC1S2 | RASA1 | 0.745121 | 3 | 0 | 3 |
| BLOC1S2 | CDC40 | 0.744739 | 3 | 0 | 3 |
| BLOC1S2 | DPY19L3 | 0.741801 | 3 | 0 | 3 |
For details and further investigation, click here
