| Full name: leptin receptor overlapping transcript | Alias Symbol: OBRGRP|OB-RGRP|VPS55|FLJ90360 | ||
| Type: protein-coding gene | Cytoband: 1p31.3 | ||
| Entrez ID: 54741 | HGNC ID: HGNC:29477 | Ensembl Gene: ENSG00000213625 | OMIM ID: 613461 |
| Drug and gene relationship at DGIdb | |||
Expression of LEPROT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LEPROT | 54741 | 202378_s_at | -0.2929 | 0.4801 | |
| GSE20347 | LEPROT | 54741 | 202378_s_at | -0.1039 | 0.4020 | |
| GSE23400 | LEPROT | 54741 | 202377_at | -0.0917 | 0.2147 | |
| GSE26886 | LEPROT | 54741 | 202378_s_at | -1.2622 | 0.0000 | |
| GSE29001 | LEPROT | 54741 | 202378_s_at | -0.0585 | 0.8565 | |
| GSE38129 | LEPROT | 54741 | 202378_s_at | -0.1979 | 0.0546 | |
| GSE45670 | LEPROT | 54741 | 202378_s_at | -0.2602 | 0.0582 | |
| GSE53622 | LEPROT | 54741 | 81220 | -0.1115 | 0.2971 | |
| GSE53624 | LEPROT | 54741 | 81220 | -0.3934 | 0.0001 | |
| GSE63941 | LEPROT | 54741 | 202377_at | -1.1376 | 0.0297 | |
| GSE77861 | LEPROT | 54741 | 202377_at | -0.5859 | 0.0287 | |
| GSE97050 | LEPROT | 54741 | A_24_P148094 | -0.0730 | 0.7632 | |
| SRP007169 | LEPROT | 54741 | RNAseq | -1.6626 | 0.0000 | |
| SRP008496 | LEPROT | 54741 | RNAseq | -1.2828 | 0.0012 | |
| SRP064894 | LEPROT | 54741 | RNAseq | -0.0297 | 0.8544 | |
| SRP133303 | LEPROT | 54741 | RNAseq | -0.0559 | 0.6878 | |
| SRP159526 | LEPROT | 54741 | RNAseq | -0.6338 | 0.0107 | |
| SRP193095 | LEPROT | 54741 | RNAseq | -0.2435 | 0.0026 | |
| SRP219564 | LEPROT | 54741 | RNAseq | -0.2145 | 0.3663 | |
| TCGA | LEPROT | 54741 | RNAseq | -0.2141 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by LEPROT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LEPROT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LEPROT | 54741 | 2 | 6 | 22 | |
| GSE20123 | LEPROT | 54741 | 2 | 5 | 23 | |
| GSE43470 | LEPROT | 54741 | 4 | 4 | 35 | |
| GSE46452 | LEPROT | 54741 | 0 | 1 | 58 | |
| GSE47630 | LEPROT | 54741 | 8 | 5 | 27 | |
| GSE54993 | LEPROT | 54741 | 0 | 0 | 70 | |
| GSE54994 | LEPROT | 54741 | 6 | 4 | 43 | |
| GSE60625 | LEPROT | 54741 | 0 | 0 | 11 | |
| GSE74703 | LEPROT | 54741 | 3 | 3 | 30 | |
| GSE74704 | LEPROT | 54741 | 1 | 2 | 17 | |
| TCGA | LEPROT | 54741 | 8 | 20 | 68 |
Total number of gains: 34; Total number of losses: 50; Total Number of normals: 404.
Somatic mutations of LEPROT:
Generating mutation plots.
Highly correlated genes for LEPROT:
Showing top 20/653 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LEPROT | BRWD3 | 0.831704 | 3 | 0 | 3 |
| LEPROT | NSA2 | 0.809932 | 3 | 0 | 3 |
| LEPROT | RGS14 | 0.809377 | 3 | 0 | 3 |
| LEPROT | ITCH | 0.79354 | 3 | 0 | 3 |
| LEPROT | ACTR1A | 0.777251 | 3 | 0 | 3 |
| LEPROT | CTTNBP2NL | 0.774549 | 4 | 0 | 4 |
| LEPROT | COMMD10 | 0.773975 | 5 | 0 | 5 |
| LEPROT | SORT1 | 0.772195 | 3 | 0 | 3 |
| LEPROT | BLVRA | 0.76352 | 3 | 0 | 3 |
| LEPROT | ATP6V1D | 0.759295 | 4 | 0 | 4 |
| LEPROT | TIFA | 0.756744 | 3 | 0 | 3 |
| LEPROT | EBPL | 0.756261 | 3 | 0 | 3 |
| LEPROT | PAIP2B | 0.755147 | 3 | 0 | 3 |
| LEPROT | SETD7 | 0.750515 | 3 | 0 | 3 |
| LEPROT | ORMDL2 | 0.748878 | 3 | 0 | 3 |
| LEPROT | MAP3K1 | 0.746505 | 3 | 0 | 3 |
| LEPROT | PIGV | 0.745609 | 3 | 0 | 3 |
| LEPROT | NLRX1 | 0.744407 | 3 | 0 | 3 |
| LEPROT | RBM20 | 0.7417 | 3 | 0 | 3 |
| LEPROT | SPRYD4 | 0.741526 | 3 | 0 | 3 |
For details and further investigation, click here
