| Full name: ring-box 1 | Alias Symbol: ROC1|RNF75|BA554C12.1 | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 9978 | HGNC ID: HGNC:9928 | Ensembl Gene: ENSG00000100387 | OMIM ID: 603814 |
| Drug and gene relationship at DGIdb | |||
RBX1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway | |
| hsa04110 | Cell cycle | |
| hsa04114 | Oocyte meiosis | |
| hsa04350 | TGF-beta signaling pathway | |
| hsa04710 | Circadian rhythm | |
| hsa05200 | Pathways in cancer |
Expression of RBX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RBX1 | 9978 | 218117_at | -0.2173 | 0.6084 | |
| GSE20347 | RBX1 | 9978 | 218117_at | -0.2542 | 0.0457 | |
| GSE23400 | RBX1 | 9978 | 218117_at | 0.0254 | 0.7399 | |
| GSE26886 | RBX1 | 9978 | 218117_at | -0.2698 | 0.1453 | |
| GSE29001 | RBX1 | 9978 | 218117_at | -0.2238 | 0.2744 | |
| GSE38129 | RBX1 | 9978 | 218117_at | -0.0526 | 0.6193 | |
| GSE45670 | RBX1 | 9978 | 218117_at | 0.0204 | 0.8765 | |
| GSE53622 | RBX1 | 9978 | 69048 | -0.0745 | 0.1679 | |
| GSE53624 | RBX1 | 9978 | 69048 | 0.1550 | 0.0006 | |
| GSE63941 | RBX1 | 9978 | 218117_at | 0.4671 | 0.1868 | |
| GSE77861 | RBX1 | 9978 | 218117_at | -0.2373 | 0.3541 | |
| GSE97050 | RBX1 | 9978 | A_33_P3246318 | -0.1307 | 0.5905 | |
| SRP007169 | RBX1 | 9978 | RNAseq | -0.8002 | 0.0182 | |
| SRP008496 | RBX1 | 9978 | RNAseq | -0.7636 | 0.0001 | |
| SRP064894 | RBX1 | 9978 | RNAseq | 0.3161 | 0.2128 | |
| SRP133303 | RBX1 | 9978 | RNAseq | -0.0064 | 0.9665 | |
| SRP159526 | RBX1 | 9978 | RNAseq | -0.1195 | 0.4809 | |
| SRP193095 | RBX1 | 9978 | RNAseq | -0.4103 | 0.0052 | |
| SRP219564 | RBX1 | 9978 | RNAseq | -0.0517 | 0.8765 | |
| TCGA | RBX1 | 9978 | RNAseq | 0.1476 | 0.0051 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RBX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RBX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RBX1 | 9978 | 6 | 5 | 19 | |
| GSE20123 | RBX1 | 9978 | 6 | 4 | 20 | |
| GSE43470 | RBX1 | 9978 | 4 | 6 | 33 | |
| GSE46452 | RBX1 | 9978 | 31 | 2 | 26 | |
| GSE47630 | RBX1 | 9978 | 9 | 4 | 27 | |
| GSE54993 | RBX1 | 9978 | 3 | 6 | 61 | |
| GSE54994 | RBX1 | 9978 | 11 | 8 | 34 | |
| GSE60625 | RBX1 | 9978 | 5 | 0 | 6 | |
| GSE74703 | RBX1 | 9978 | 4 | 4 | 28 | |
| GSE74704 | RBX1 | 9978 | 3 | 2 | 15 | |
| TCGA | RBX1 | 9978 | 26 | 14 | 56 |
Total number of gains: 108; Total number of losses: 55; Total Number of normals: 325.
Somatic mutations of RBX1:
Generating mutation plots.
Highly correlated genes for RBX1:
Showing top 20/401 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RBX1 | PKN2 | 0.795896 | 3 | 0 | 3 |
| RBX1 | LANCL1 | 0.74601 | 3 | 0 | 3 |
| RBX1 | GLTP | 0.744878 | 3 | 0 | 3 |
| RBX1 | PTGR1 | 0.743982 | 3 | 0 | 3 |
| RBX1 | GAPVD1 | 0.740702 | 3 | 0 | 3 |
| RBX1 | MKKS | 0.738198 | 3 | 0 | 3 |
| RBX1 | SCYL2 | 0.737692 | 3 | 0 | 3 |
| RBX1 | BDKRB2 | 0.728154 | 3 | 0 | 3 |
| RBX1 | TRIM61 | 0.727446 | 3 | 0 | 3 |
| RBX1 | C1orf56 | 0.725487 | 3 | 0 | 3 |
| RBX1 | NDUFA12 | 0.720844 | 3 | 0 | 3 |
| RBX1 | DAAM1 | 0.720798 | 3 | 0 | 3 |
| RBX1 | VPS29 | 0.717719 | 4 | 0 | 3 |
| RBX1 | ZNF70 | 0.717368 | 3 | 0 | 3 |
| RBX1 | ACTR1A | 0.716634 | 3 | 0 | 3 |
| RBX1 | LRRC28 | 0.708755 | 4 | 0 | 3 |
| RBX1 | MRPL30 | 0.708673 | 4 | 0 | 4 |
| RBX1 | RTN3 | 0.706189 | 3 | 0 | 3 |
| RBX1 | ATP11B | 0.691812 | 4 | 0 | 3 |
| RBX1 | YME1L1 | 0.691385 | 4 | 0 | 3 |
For details and further investigation, click here
