| Full name: BRICK1 subunit of SCAR/WAVE actin nucleating complex | Alias Symbol: MDS027|HSPC300 | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 55845 | HGNC ID: HGNC:23057 | Ensembl Gene: ENSG00000254999 | OMIM ID: 611183 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
BRK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04810 | Regulation of actin cytoskeleton |
Expression of BRK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRK1 | 55845 | 224575_at | -0.5236 | 0.0938 | |
| GSE26886 | BRK1 | 55845 | 224575_at | -1.3510 | 0.0000 | |
| GSE45670 | BRK1 | 55845 | 224575_at | -0.3684 | 0.0021 | |
| GSE53622 | BRK1 | 55845 | 405 | -0.9173 | 0.0000 | |
| GSE53624 | BRK1 | 55845 | 405 | -0.7297 | 0.0000 | |
| GSE63941 | BRK1 | 55845 | 224575_at | -0.5899 | 0.1894 | |
| GSE77861 | BRK1 | 55845 | 224575_at | -0.7377 | 0.0018 | |
| GSE97050 | BRK1 | 55845 | A_23_P420361 | -0.3671 | 0.1410 | |
| SRP007169 | BRK1 | 55845 | RNAseq | -0.4454 | 0.5476 | |
| SRP008496 | BRK1 | 55845 | RNAseq | -1.5304 | 0.0000 | |
| SRP064894 | BRK1 | 55845 | RNAseq | -0.4814 | 0.0791 | |
| SRP133303 | BRK1 | 55845 | RNAseq | -0.6591 | 0.0000 | |
| SRP159526 | BRK1 | 55845 | RNAseq | -0.8128 | 0.0005 | |
| SRP193095 | BRK1 | 55845 | RNAseq | -1.1199 | 0.0000 | |
| SRP219564 | BRK1 | 55845 | RNAseq | -1.0875 | 0.0092 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by BRK1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of BRK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRK1 | 55845 | 1 | 18 | 11 | |
| GSE20123 | BRK1 | 55845 | 1 | 18 | 11 | |
| GSE43470 | BRK1 | 55845 | 1 | 20 | 22 | |
| GSE46452 | BRK1 | 55845 | 2 | 17 | 40 | |
| GSE47630 | BRK1 | 55845 | 2 | 23 | 15 | |
| GSE54993 | BRK1 | 55845 | 6 | 1 | 63 | |
| GSE54994 | BRK1 | 55845 | 3 | 31 | 19 | |
| GSE60625 | BRK1 | 55845 | 5 | 0 | 6 | |
| GSE74703 | BRK1 | 55845 | 1 | 16 | 19 | |
| GSE74704 | BRK1 | 55845 | 1 | 11 | 8 | |
| TCGA | BRK1 | 55845 | 6 | 64 | 26 |
Total number of gains: 29; Total number of losses: 219; Total Number of normals: 240.
Somatic mutations of BRK1:
Generating mutation plots.
Highly correlated genes for BRK1:
Showing top 20/1816 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRK1 | IMPACT | 0.816511 | 3 | 0 | 3 |
| BRK1 | SNORA68 | 0.809078 | 4 | 0 | 4 |
| BRK1 | GPD1L | 0.804755 | 7 | 0 | 7 |
| BRK1 | UBE2E1 | 0.803457 | 6 | 0 | 6 |
| BRK1 | FCER1A | 0.801316 | 6 | 0 | 6 |
| BRK1 | ZCCHC9 | 0.800004 | 3 | 0 | 3 |
| BRK1 | RHOA | 0.798942 | 8 | 0 | 7 |
| BRK1 | MPP7 | 0.795684 | 7 | 0 | 7 |
| BRK1 | EPB41L3 | 0.790861 | 7 | 0 | 7 |
| BRK1 | HIGD1A | 0.789398 | 7 | 0 | 7 |
| BRK1 | DLD | 0.785475 | 3 | 0 | 3 |
| BRK1 | SH3GLB1 | 0.783759 | 7 | 0 | 6 |
| BRK1 | RAB11A | 0.783569 | 7 | 0 | 7 |
| BRK1 | AK3 | 0.779966 | 7 | 0 | 7 |
| BRK1 | HPGD | 0.77783 | 7 | 0 | 7 |
| BRK1 | CHMP2B | 0.776953 | 7 | 0 | 7 |
| BRK1 | ELMO2 | 0.776831 | 6 | 0 | 6 |
| BRK1 | GOLGA4 | 0.774391 | 5 | 0 | 5 |
| BRK1 | RRAGD | 0.773847 | 7 | 0 | 7 |
| BRK1 | PAIP2B | 0.773483 | 7 | 0 | 7 |
For details and further investigation, click here
