| Full name: ELKS/RAB6-interacting/CAST family member 1 | Alias Symbol: ELKS|KIAA1081|CAST2|MGC12974 | ||
| Type: protein-coding gene | Cytoband: 12p13.33 | ||
| Entrez ID: 23085 | HGNC ID: HGNC:17072 | Ensembl Gene: ENSG00000082805 | OMIM ID: 607127 |
| Drug and gene relationship at DGIdb | |||
Expression of ERC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERC1 | 23085 | 226049_at | 0.1229 | 0.7523 | |
| GSE20347 | ERC1 | 23085 | 215606_s_at | -0.2589 | 0.2932 | |
| GSE23400 | ERC1 | 23085 | 215606_s_at | -0.0622 | 0.4873 | |
| GSE26886 | ERC1 | 23085 | 226049_at | 0.3466 | 0.1967 | |
| GSE29001 | ERC1 | 23085 | 215606_s_at | -0.0341 | 0.9149 | |
| GSE38129 | ERC1 | 23085 | 215606_s_at | -0.3773 | 0.1134 | |
| GSE45670 | ERC1 | 23085 | 226049_at | 0.1548 | 0.2630 | |
| GSE53622 | ERC1 | 23085 | 13664 | -0.1330 | 0.1529 | |
| GSE53624 | ERC1 | 23085 | 13664 | 0.0271 | 0.7011 | |
| GSE63941 | ERC1 | 23085 | 226049_at | -0.3035 | 0.5412 | |
| GSE77861 | ERC1 | 23085 | 226049_at | 0.1319 | 0.5394 | |
| GSE97050 | ERC1 | 23085 | A_24_P694760 | -0.3663 | 0.1623 | |
| SRP007169 | ERC1 | 23085 | RNAseq | 0.5496 | 0.1863 | |
| SRP008496 | ERC1 | 23085 | RNAseq | 0.6944 | 0.0276 | |
| SRP064894 | ERC1 | 23085 | RNAseq | -0.2968 | 0.1065 | |
| SRP133303 | ERC1 | 23085 | RNAseq | 0.3973 | 0.0544 | |
| SRP159526 | ERC1 | 23085 | RNAseq | -0.4091 | 0.1593 | |
| SRP193095 | ERC1 | 23085 | RNAseq | 0.2773 | 0.0402 | |
| SRP219564 | ERC1 | 23085 | RNAseq | -0.4298 | 0.2384 | |
| TCGA | ERC1 | 23085 | RNAseq | -0.0113 | 0.8403 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ERC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ERC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERC1 | 23085 | 9 | 4 | 17 | |
| GSE20123 | ERC1 | 23085 | 8 | 4 | 18 | |
| GSE43470 | ERC1 | 23085 | 11 | 3 | 29 | |
| GSE46452 | ERC1 | 23085 | 10 | 1 | 48 | |
| GSE47630 | ERC1 | 23085 | 12 | 2 | 26 | |
| GSE54993 | ERC1 | 23085 | 1 | 10 | 59 | |
| GSE54994 | ERC1 | 23085 | 10 | 2 | 41 | |
| GSE60625 | ERC1 | 23085 | 0 | 1 | 10 | |
| GSE74703 | ERC1 | 23085 | 10 | 2 | 24 | |
| GSE74704 | ERC1 | 23085 | 5 | 2 | 13 | |
| TCGA | ERC1 | 23085 | 38 | 8 | 50 |
Total number of gains: 114; Total number of losses: 39; Total Number of normals: 335.
Somatic mutations of ERC1:
Generating mutation plots.
Highly correlated genes for ERC1:
Showing top 20/95 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERC1 | ITIH5 | 0.777458 | 3 | 0 | 3 |
| ERC1 | RNF121 | 0.773507 | 3 | 0 | 3 |
| ERC1 | ACTR1A | 0.740487 | 3 | 0 | 3 |
| ERC1 | COMT | 0.731605 | 3 | 0 | 3 |
| ERC1 | CRIP1 | 0.720467 | 3 | 0 | 3 |
| ERC1 | NKX2-5 | 0.701259 | 3 | 0 | 3 |
| ERC1 | KPNA6 | 0.69905 | 3 | 0 | 3 |
| ERC1 | GHDC | 0.691659 | 3 | 0 | 3 |
| ERC1 | GLYR1 | 0.688551 | 3 | 0 | 3 |
| ERC1 | RTN1 | 0.687514 | 3 | 0 | 3 |
| ERC1 | ASB9 | 0.683078 | 3 | 0 | 3 |
| ERC1 | ANP32D | 0.679741 | 3 | 0 | 3 |
| ERC1 | ERGIC2 | 0.663816 | 4 | 0 | 3 |
| ERC1 | KRTCAP2 | 0.660234 | 3 | 0 | 3 |
| ERC1 | FLOT2 | 0.654731 | 6 | 0 | 5 |
| ERC1 | LSM12 | 0.651861 | 3 | 0 | 3 |
| ERC1 | RAB8A | 0.649355 | 4 | 0 | 3 |
| ERC1 | PHACTR1 | 0.642741 | 3 | 0 | 3 |
| ERC1 | FKBP4 | 0.639571 | 4 | 0 | 3 |
| ERC1 | ENG | 0.637683 | 3 | 0 | 3 |
For details and further investigation, click here
