ADAM28

 

Full name: ADAM metallopeptidase domain 28 Alias Symbol: eMDCII|MDC-Lm|MDC-Ls|ADAM23
Type: protein-coding gene Cytoband: 8p21.2
Entrez ID: 10863 HGNC ID: HGNC:206 Ensembl Gene: ENSG00000042980 OMIM ID: 606188
Drug and gene relationship at DGIdb

 

Expression of ADAM28:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADAM28 10863 205997_at 0.1706 0.9144
GSE20347 ADAM28 10863 208269_s_at -0.0777 0.4729
GSE23400 ADAM28 10863 208269_s_at -0.1220 0.0010
GSE26886 ADAM28 10863 208269_s_at 0.0468 0.7332
GSE29001 ADAM28 10863 208268_at 0.3451 0.5342
GSE38129 ADAM28 10863 208269_s_at -0.1690 0.0754
GSE45670 ADAM28 10863 205997_at 0.4750 0.3326
GSE53622 ADAM28 10863 66269 0.0403 0.8607
GSE53624 ADAM28 10863 66269 -0.5306 0.0028
GSE63941 ADAM28 10863 208269_s_at 0.2928 0.3858
GSE77861 ADAM28 10863 208269_s_at -0.0214 0.8940
GSE97050 ADAM28 10863 A_33_P3380652 0.6231 0.1673
SRP064894 ADAM28 10863 RNAseq 0.5435 0.1002
SRP133303 ADAM28 10863 RNAseq -0.2697 0.4028
SRP159526 ADAM28 10863 RNAseq -0.6884 0.3498
SRP193095 ADAM28 10863 RNAseq -0.8415 0.0957
SRP219564 ADAM28 10863 RNAseq 0.6264 0.2313
TCGA ADAM28 10863 RNAseq -1.2577 0.0000

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by ADAM28 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADAM28:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADAM28 10863 4 12 14
GSE20123 ADAM28 10863 4 12 14
GSE43470 ADAM28 10863 4 8 31
GSE46452 ADAM28 10863 13 13 33
GSE47630 ADAM28 10863 10 8 22
GSE54993 ADAM28 10863 2 14 54
GSE54994 ADAM28 10863 8 18 27
GSE60625 ADAM28 10863 3 0 8
GSE74703 ADAM28 10863 4 7 25
GSE74704 ADAM28 10863 3 8 9
TCGA ADAM28 10863 15 43 38

Total number of gains: 70; Total number of losses: 143; Total Number of normals: 275.  

 

Somatic mutations of ADAM28:

 

Generating mutation plots.

 

Highly correlated genes for ADAM28:

 

Showing top 20/361 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADAM28PHLDB10.704522303
ADAM28GPR1740.695863303
ADAM28KRT760.677669303
ADAM28ICOSLG0.674908303
ADAM28CD50.668891707
ADAM28RHOH0.662932806
ADAM28PLCL20.662277303
ADAM28CD380.660311303
ADAM28GPR650.655061504
ADAM28ART10.652814303
ADAM28KIR3DL30.650117404
ADAM28GPATCH40.647616404
ADAM28GPRIN30.64612403
ADAM28CD370.642236505
ADAM28IL17A0.641323504
ADAM28CD690.638834303
ADAM28C1orf1050.638605404
ADAM28RLBP10.63785303
ADAM28ZNF8310.637649303
ADAM28KCNJ60.637127303

For details and further investigation, click here