| Full name: interleukin 17A | Alias Symbol: IL-17A|IL-17 | ||
| Type: protein-coding gene | Cytoband: 6p12.2 | ||
| Entrez ID: 3605 | HGNC ID: HGNC:5981 | Ensembl Gene: ENSG00000112115 | OMIM ID: 603149 |
| Drug and gene relationship at DGIdb | |||
IL17A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL17A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL17A | 3605 | 208402_at | -0.0070 | 0.9798 | |
| GSE20347 | IL17A | 3605 | 208402_at | -0.0141 | 0.8697 | |
| GSE23400 | IL17A | 3605 | 208402_at | -0.1712 | 0.0000 | |
| GSE26886 | IL17A | 3605 | 208402_at | -0.2174 | 0.0723 | |
| GSE29001 | IL17A | 3605 | 208402_at | -0.0661 | 0.6461 | |
| GSE38129 | IL17A | 3605 | 208402_at | -0.0951 | 0.1493 | |
| GSE45670 | IL17A | 3605 | 216876_s_at | 0.4033 | 0.1218 | |
| GSE53622 | IL17A | 3605 | 39926 | 0.3292 | 0.0039 | |
| GSE53624 | IL17A | 3605 | 39926 | 0.7936 | 0.0000 | |
| GSE63941 | IL17A | 3605 | 208402_at | -0.0212 | 0.8991 | |
| GSE77861 | IL17A | 3605 | 208402_at | -0.0285 | 0.7333 | |
| TCGA | IL17A | 3605 | RNAseq | 3.2610 | 0.0065 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by IL17A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL17A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL17A | 3605 | 7 | 2 | 21 | |
| GSE20123 | IL17A | 3605 | 8 | 2 | 20 | |
| GSE43470 | IL17A | 3605 | 5 | 0 | 38 | |
| GSE46452 | IL17A | 3605 | 3 | 10 | 46 | |
| GSE47630 | IL17A | 3605 | 7 | 5 | 28 | |
| GSE54993 | IL17A | 3605 | 3 | 1 | 66 | |
| GSE54994 | IL17A | 3605 | 8 | 4 | 41 | |
| GSE60625 | IL17A | 3605 | 0 | 3 | 8 | |
| GSE74703 | IL17A | 3605 | 5 | 0 | 31 | |
| GSE74704 | IL17A | 3605 | 4 | 1 | 15 | |
| TCGA | IL17A | 3605 | 22 | 12 | 62 |
Total number of gains: 72; Total number of losses: 40; Total Number of normals: 376.
Somatic mutations of IL17A:
Generating mutation plots.
Highly correlated genes for IL17A:
Showing top 20/826 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL17A | TCP10L | 0.75258 | 5 | 0 | 5 |
| IL17A | IFNA21 | 0.73066 | 5 | 0 | 5 |
| IL17A | ODF1 | 0.718504 | 4 | 0 | 4 |
| IL17A | DAB1 | 0.715386 | 6 | 0 | 6 |
| IL17A | ADAM11 | 0.708803 | 4 | 0 | 4 |
| IL17A | ITGB3 | 0.707474 | 4 | 0 | 4 |
| IL17A | LINC00563 | 0.707449 | 5 | 0 | 5 |
| IL17A | P2RX6 | 0.704327 | 5 | 0 | 5 |
| IL17A | POU4F2 | 0.701514 | 3 | 0 | 3 |
| IL17A | LRTM1 | 0.700022 | 5 | 0 | 5 |
| IL17A | DPEP1 | 0.696196 | 5 | 0 | 5 |
| IL17A | G6PC2 | 0.695863 | 5 | 0 | 5 |
| IL17A | SCNN1G | 0.694647 | 4 | 0 | 4 |
| IL17A | CYP2D6 | 0.69142 | 4 | 0 | 4 |
| IL17A | SLC28A2 | 0.690255 | 4 | 0 | 4 |
| IL17A | PRL | 0.689883 | 5 | 0 | 4 |
| IL17A | CYP11B1 | 0.689773 | 4 | 0 | 4 |
| IL17A | GLYAT | 0.689234 | 4 | 0 | 4 |
| IL17A | LRRC75B | 0.688696 | 3 | 0 | 3 |
| IL17A | KRTAP5-8 | 0.688406 | 5 | 0 | 5 |
For details and further investigation, click here
