| Full name: potassium inwardly rectifying channel subfamily J member 6 | Alias Symbol: Kir3.2|GIRK2|KATP2|BIR1|hiGIRK2 | ||
| Type: protein-coding gene | Cytoband: 21q22.13 | ||
| Entrez ID: 3763 | HGNC ID: HGNC:6267 | Ensembl Gene: ENSG00000157542 | OMIM ID: 600877 |
| Drug and gene relationship at DGIdb | |||
KCNJ6 involved pathways:
Expression of KCNJ6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNJ6 | 3763 | 210454_s_at | -0.1846 | 0.6008 | |
| GSE20347 | KCNJ6 | 3763 | 210454_s_at | -0.1104 | 0.0907 | |
| GSE23400 | KCNJ6 | 3763 | 210454_s_at | -0.2162 | 0.0000 | |
| GSE26886 | KCNJ6 | 3763 | 210454_s_at | -0.0628 | 0.6554 | |
| GSE29001 | KCNJ6 | 3763 | 210454_s_at | -0.1417 | 0.2899 | |
| GSE38129 | KCNJ6 | 3763 | 210454_s_at | -0.1668 | 0.0871 | |
| GSE45670 | KCNJ6 | 3763 | 210454_s_at | 0.0378 | 0.7648 | |
| GSE53622 | KCNJ6 | 3763 | 41417 | 0.0342 | 0.8534 | |
| GSE53624 | KCNJ6 | 3763 | 41417 | 0.4978 | 0.0005 | |
| GSE63941 | KCNJ6 | 3763 | 210454_s_at | -0.9271 | 0.0005 | |
| GSE77861 | KCNJ6 | 3763 | 210454_s_at | -0.1996 | 0.0791 | |
| SRP064894 | KCNJ6 | 3763 | RNAseq | 0.4496 | 0.1152 | |
| SRP133303 | KCNJ6 | 3763 | RNAseq | 0.1975 | 0.1474 | |
| SRP159526 | KCNJ6 | 3763 | RNAseq | 0.8510 | 0.0500 | |
| SRP193095 | KCNJ6 | 3763 | RNAseq | 0.3024 | 0.0316 | |
| SRP219564 | KCNJ6 | 3763 | RNAseq | 0.6589 | 0.1216 | |
| TCGA | KCNJ6 | 3763 | RNAseq | 0.4068 | 0.6220 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KCNJ6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNJ6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNJ6 | 3763 | 2 | 8 | 20 | |
| GSE20123 | KCNJ6 | 3763 | 2 | 9 | 19 | |
| GSE43470 | KCNJ6 | 3763 | 1 | 11 | 31 | |
| GSE46452 | KCNJ6 | 3763 | 1 | 21 | 37 | |
| GSE47630 | KCNJ6 | 3763 | 6 | 17 | 17 | |
| GSE54993 | KCNJ6 | 3763 | 8 | 1 | 61 | |
| GSE54994 | KCNJ6 | 3763 | 3 | 9 | 41 | |
| GSE60625 | KCNJ6 | 3763 | 0 | 0 | 11 | |
| GSE74703 | KCNJ6 | 3763 | 1 | 8 | 27 | |
| GSE74704 | KCNJ6 | 3763 | 1 | 6 | 13 | |
| TCGA | KCNJ6 | 3763 | 8 | 41 | 47 |
Total number of gains: 33; Total number of losses: 131; Total Number of normals: 324.
Somatic mutations of KCNJ6:
Generating mutation plots.
Highly correlated genes for KCNJ6:
Showing top 20/672 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNJ6 | CYP2A6 | 0.687596 | 6 | 0 | 6 |
| KCNJ6 | VASN | 0.687399 | 3 | 0 | 3 |
| KCNJ6 | HFE | 0.682357 | 3 | 0 | 3 |
| KCNJ6 | PDK4 | 0.672212 | 3 | 0 | 3 |
| KCNJ6 | ATP6V1G2 | 0.671226 | 4 | 0 | 4 |
| KCNJ6 | PAPOLB | 0.66973 | 3 | 0 | 3 |
| KCNJ6 | BTN1A1 | 0.66481 | 4 | 0 | 4 |
| KCNJ6 | OTOR | 0.66463 | 6 | 0 | 6 |
| KCNJ6 | HLA-DOA | 0.657151 | 6 | 0 | 5 |
| KCNJ6 | CTSE | 0.656548 | 4 | 0 | 3 |
| KCNJ6 | RNF17 | 0.65271 | 4 | 0 | 4 |
| KCNJ6 | FOXN1 | 0.651111 | 5 | 0 | 5 |
| KCNJ6 | POU4F3 | 0.644258 | 4 | 0 | 3 |
| KCNJ6 | KIR2DS5 | 0.64396 | 4 | 0 | 4 |
| KCNJ6 | ZFHX2 | 0.6433 | 7 | 0 | 7 |
| KCNJ6 | CPN1 | 0.642618 | 5 | 0 | 4 |
| KCNJ6 | EGFLAM-AS2 | 0.642228 | 4 | 0 | 3 |
| KCNJ6 | PHLDB1 | 0.638435 | 6 | 0 | 5 |
| KCNJ6 | KIAA1614 | 0.637245 | 7 | 0 | 6 |
| KCNJ6 | ADAM28 | 0.637127 | 3 | 0 | 3 |
For details and further investigation, click here
