CD38

 

Full name: CD38 molecule Alias Symbol: 
Type: protein-coding gene Cytoband: 4p15.32
Entrez ID: 952 HGNC ID: HGNC:1667 Ensembl Gene: ENSG00000004468 OMIM ID: 107270
Drug and gene relationship at DGIdb

 

CD38 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04921Oxytocin signaling pathway
hsa04970Salivary secretion
hsa04972Pancreatic secretion

 

Expression of CD38:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CD38 952 205692_s_at 0.9624 0.1726
GSE20347 CD38 952 205692_s_at 0.5168 0.0024
GSE23400 CD38 952 205692_s_at 0.2629 0.0002
GSE26886 CD38 952 205692_s_at 0.8372 0.0074
GSE29001 CD38 952 205692_s_at 0.9561 0.0001
GSE38129 CD38 952 205692_s_at 0.5653 0.0004
GSE45670 CD38 952 205692_s_at 1.2362 0.0061
GSE53622 CD38 952 136064 -1.8378 0.0000
GSE53624 CD38 952 136064 -2.6282 0.0000
GSE63941 CD38 952 205692_s_at 0.1817 0.8113
GSE77861 CD38 952 205692_s_at 0.0692 0.7679
GSE97050 CD38 952 A_23_P167328 0.7482 0.4032
SRP007169 CD38 952 RNAseq 0.4831 0.5567
SRP064894 CD38 952 RNAseq 1.1647 0.0002
SRP133303 CD38 952 RNAseq 0.5130 0.1077
SRP159526 CD38 952 RNAseq 1.4495 0.0204
SRP193095 CD38 952 RNAseq 0.4694 0.0301
SRP219564 CD38 952 RNAseq 1.3849 0.0017
TCGA CD38 952 RNAseq 0.5742 0.0215

Upregulated datasets: 4; Downregulated datasets: 2.  

 

Survival by CD38 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CD38:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CD38 952 0 18 12
GSE20123 CD38 952 0 18 12
GSE43470 CD38 952 1 15 27
GSE46452 CD38 952 1 36 22
GSE47630 CD38 952 1 19 20
GSE54993 CD38 952 10 0 60
GSE54994 CD38 952 4 12 37
GSE60625 CD38 952 0 0 11
GSE74703 CD38 952 1 13 22
GSE74704 CD38 952 0 11 9
TCGA CD38 952 9 48 39

Total number of gains: 27; Total number of losses: 190; Total Number of normals: 271.  

 

Somatic mutations of CD38:

 

Generating mutation plots.

 

Highly correlated genes for CD38:

 

Showing top 20/171 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CD38UHRF20.795462303
CD38ZNF1010.775363303
CD38PTPN220.766439404
CD38MTHFD2L0.743383303
CD38TNFRSF1B0.726388303
CD38SIPA10.723711303
CD38TMEM1650.717748303
CD38GOLPH30.701607303
CD38GSTA30.683508303
CD38ZC3H12D0.679551505
CD38SSH20.676887403
CD38ELOVL10.674026303
CD38NUAK20.672105303
CD38LTA4H0.671578303
CD38FANCD20.667051303
CD38ZBED10.667042303
CD38TRAPPC3L0.663356303
CD38ADAM280.660311303
CD38SGK10.654535303
CD38PLSCR10.652124403

For details and further investigation, click here