| Full name: inducible T cell costimulator ligand | Alias Symbol: KIAA0653|GL50|B7-H2|B7RP-1|B7H2|B7RP1|ICOS-L|CD275|B7h | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 23308 | HGNC ID: HGNC:17087 | Ensembl Gene: ENSG00000160223 | OMIM ID: 605717 |
| Drug and gene relationship at DGIdb | |||
Expression of ICOSLG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ICOSLG | 23308 | 213450_s_at | -0.0239 | 0.9456 | |
| GSE20347 | ICOSLG | 23308 | 213450_s_at | -0.1726 | 0.0787 | |
| GSE23400 | ICOSLG | 23308 | 213450_s_at | -0.1906 | 0.0000 | |
| GSE26886 | ICOSLG | 23308 | 213450_s_at | -0.2521 | 0.0724 | |
| GSE29001 | ICOSLG | 23308 | 211197_s_at | -0.1663 | 0.2666 | |
| GSE38129 | ICOSLG | 23308 | 213450_s_at | -0.2246 | 0.0025 | |
| GSE45670 | ICOSLG | 23308 | 213450_s_at | -0.0758 | 0.5254 | |
| GSE53622 | ICOSLG | 23308 | 144801 | -0.5859 | 0.0018 | |
| GSE53624 | ICOSLG | 23308 | 144801 | -0.7455 | 0.0000 | |
| GSE63941 | ICOSLG | 23308 | 213450_s_at | 0.1932 | 0.3880 | |
| GSE77861 | ICOSLG | 23308 | 213450_s_at | -0.1284 | 0.1930 | |
| GSE97050 | ICOSLG | 23308 | A_23_P317667 | 0.1267 | 0.7756 | |
| SRP007169 | ICOSLG | 23308 | RNAseq | -0.3699 | 0.5275 | |
| SRP008496 | ICOSLG | 23308 | RNAseq | -0.7003 | 0.0697 | |
| SRP064894 | ICOSLG | 23308 | RNAseq | -1.0227 | 0.0000 | |
| SRP133303 | ICOSLG | 23308 | RNAseq | -0.7430 | 0.0000 | |
| SRP159526 | ICOSLG | 23308 | RNAseq | -0.3747 | 0.4932 | |
| SRP193095 | ICOSLG | 23308 | RNAseq | -0.4067 | 0.0157 | |
| SRP219564 | ICOSLG | 23308 | RNAseq | -0.4167 | 0.4474 | |
| TCGA | ICOSLG | 23308 | RNAseq | -0.0542 | 0.6162 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ICOSLG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ICOSLG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ICOSLG | 23308 | 2 | 8 | 20 | |
| GSE20123 | ICOSLG | 23308 | 2 | 8 | 20 | |
| GSE43470 | ICOSLG | 23308 | 0 | 13 | 30 | |
| GSE46452 | ICOSLG | 23308 | 1 | 21 | 37 | |
| GSE47630 | ICOSLG | 23308 | 6 | 17 | 17 | |
| GSE54993 | ICOSLG | 23308 | 8 | 1 | 61 | |
| GSE54994 | ICOSLG | 23308 | 4 | 8 | 41 | |
| GSE60625 | ICOSLG | 23308 | 0 | 0 | 11 | |
| GSE74703 | ICOSLG | 23308 | 0 | 10 | 26 | |
| GSE74704 | ICOSLG | 23308 | 1 | 4 | 15 | |
| TCGA | ICOSLG | 23308 | 8 | 39 | 49 |
Total number of gains: 32; Total number of losses: 129; Total Number of normals: 327.
Somatic mutations of ICOSLG:
Generating mutation plots.
Highly correlated genes for ICOSLG:
Showing top 20/699 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ICOSLG | CPA5 | 0.68475 | 4 | 0 | 4 |
| ICOSLG | CAMK2B | 0.683087 | 7 | 0 | 7 |
| ICOSLG | CACNG6 | 0.675243 | 4 | 0 | 4 |
| ICOSLG | ADAM28 | 0.674908 | 3 | 0 | 3 |
| ICOSLG | CYP2A6 | 0.651286 | 8 | 0 | 8 |
| ICOSLG | PSG1 | 0.6481 | 7 | 0 | 5 |
| ICOSLG | RCOR2 | 0.646614 | 3 | 0 | 3 |
| ICOSLG | PDXK | 0.643306 | 3 | 0 | 3 |
| ICOSLG | MVK | 0.642844 | 8 | 0 | 7 |
| ICOSLG | GPR26 | 0.639688 | 3 | 0 | 3 |
| ICOSLG | CARS-AS1 | 0.637995 | 3 | 0 | 3 |
| ICOSLG | MIR4755 | 0.637377 | 4 | 0 | 4 |
| ICOSLG | ASPDH | 0.635022 | 4 | 0 | 3 |
| ICOSLG | RHBG | 0.634986 | 9 | 0 | 9 |
| ICOSLG | ZNF821 | 0.632526 | 3 | 0 | 3 |
| ICOSLG | CCDC157 | 0.632319 | 5 | 0 | 5 |
| ICOSLG | TSGA13 | 0.630692 | 3 | 0 | 3 |
| ICOSLG | DRD2 | 0.629956 | 10 | 0 | 8 |
| ICOSLG | CPN1 | 0.629034 | 7 | 0 | 6 |
| ICOSLG | OR4D2 | 0.627844 | 5 | 0 | 4 |
For details and further investigation, click here
