| Full name: G protein-coupled receptor 65 | Alias Symbol: hTDAG8|TDAG8 | ||
| Type: protein-coding gene | Cytoband: 14q31.3 | ||
| Entrez ID: 8477 | HGNC ID: HGNC:4517 | Ensembl Gene: ENSG00000140030 | OMIM ID: 604620 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR65:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR65 | 8477 | 214467_at | 0.4584 | 0.6697 | |
| GSE20347 | GPR65 | 8477 | 214467_at | -0.0468 | 0.7129 | |
| GSE23400 | GPR65 | 8477 | 214467_at | 0.1053 | 0.0047 | |
| GSE26886 | GPR65 | 8477 | 214467_at | -0.1035 | 0.7613 | |
| GSE29001 | GPR65 | 8477 | 214467_at | 0.2963 | 0.0860 | |
| GSE38129 | GPR65 | 8477 | 214467_at | 0.0248 | 0.8941 | |
| GSE45670 | GPR65 | 8477 | 214467_at | -0.3064 | 0.3293 | |
| GSE53622 | GPR65 | 8477 | 88535 | 0.1010 | 0.5941 | |
| GSE53624 | GPR65 | 8477 | 88535 | -0.0822 | 0.7380 | |
| GSE63941 | GPR65 | 8477 | 214467_at | -0.8496 | 0.0006 | |
| GSE77861 | GPR65 | 8477 | 214467_at | 0.0540 | 0.4895 | |
| GSE97050 | GPR65 | 8477 | A_23_P14564 | 0.5318 | 0.2157 | |
| SRP007169 | GPR65 | 8477 | RNAseq | 0.6787 | 0.3804 | |
| SRP064894 | GPR65 | 8477 | RNAseq | 0.5246 | 0.0593 | |
| SRP133303 | GPR65 | 8477 | RNAseq | 0.2956 | 0.2450 | |
| SRP159526 | GPR65 | 8477 | RNAseq | -0.2965 | 0.7387 | |
| SRP193095 | GPR65 | 8477 | RNAseq | 0.4741 | 0.0169 | |
| SRP219564 | GPR65 | 8477 | RNAseq | 0.3600 | 0.5366 | |
| TCGA | GPR65 | 8477 | RNAseq | 0.1689 | 0.4196 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GPR65 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR65:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR65 | 8477 | 7 | 4 | 19 | |
| GSE20123 | GPR65 | 8477 | 7 | 4 | 19 | |
| GSE43470 | GPR65 | 8477 | 8 | 3 | 32 | |
| GSE46452 | GPR65 | 8477 | 16 | 3 | 40 | |
| GSE47630 | GPR65 | 8477 | 11 | 8 | 21 | |
| GSE54993 | GPR65 | 8477 | 3 | 8 | 59 | |
| GSE54994 | GPR65 | 8477 | 19 | 4 | 30 | |
| GSE60625 | GPR65 | 8477 | 0 | 2 | 9 | |
| GSE74703 | GPR65 | 8477 | 6 | 3 | 27 | |
| GSE74704 | GPR65 | 8477 | 4 | 4 | 12 | |
| TCGA | GPR65 | 8477 | 31 | 21 | 44 |
Total number of gains: 112; Total number of losses: 64; Total Number of normals: 312.
Somatic mutations of GPR65:
Generating mutation plots.
Highly correlated genes for GPR65:
Showing top 20/573 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR65 | SNX20 | 0.825188 | 5 | 0 | 5 |
| GPR65 | C16orf54 | 0.799509 | 6 | 0 | 6 |
| GPR65 | SLC43A2 | 0.795346 | 3 | 0 | 3 |
| GPR65 | GPR141 | 0.774882 | 3 | 0 | 3 |
| GPR65 | ARHGAP9 | 0.773942 | 6 | 0 | 6 |
| GPR65 | TNFAIP8L2 | 0.768122 | 6 | 0 | 6 |
| GPR65 | PIK3R5 | 0.766766 | 5 | 0 | 4 |
| GPR65 | PLCB2 | 0.764008 | 4 | 0 | 4 |
| GPR65 | C19orf38 | 0.761131 | 3 | 0 | 3 |
| GPR65 | SAMSN1 | 0.757718 | 12 | 0 | 12 |
| GPR65 | MPEG1 | 0.753763 | 6 | 0 | 6 |
| GPR65 | PREX1 | 0.74191 | 4 | 0 | 3 |
| GPR65 | ST8SIA4 | 0.735825 | 7 | 0 | 6 |
| GPR65 | SLA | 0.732938 | 11 | 0 | 11 |
| GPR65 | NOA1 | 0.732067 | 3 | 0 | 3 |
| GPR65 | CD53 | 0.732059 | 10 | 0 | 8 |
| GPR65 | GPR34 | 0.728308 | 7 | 0 | 6 |
| GPR65 | NCKAP1L | 0.724043 | 9 | 0 | 9 |
| GPR65 | CERKL | 0.723668 | 3 | 0 | 3 |
| GPR65 | NFE2L3 | 0.72219 | 3 | 0 | 3 |
For details and further investigation, click here
