| Full name: myosin light chain kinase 2 | Alias Symbol: skMLCK|KMLC|MLCK2 | ||
| Type: protein-coding gene | Cytoband: 20q11.21 | ||
| Entrez ID: 85366 | HGNC ID: HGNC:16243 | Ensembl Gene: ENSG00000101306 | OMIM ID: 606566 |
| Drug and gene relationship at DGIdb | |||
MYLK2 involved pathways:
Expression of MYLK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYLK2 | 85366 | 231792_at | -0.1031 | 0.5545 | |
| GSE26886 | MYLK2 | 85366 | 231792_at | -0.0380 | 0.8216 | |
| GSE45670 | MYLK2 | 85366 | 231792_at | -0.0527 | 0.5641 | |
| GSE53622 | MYLK2 | 85366 | 109465 | 0.5718 | 0.0000 | |
| GSE53624 | MYLK2 | 85366 | 109465 | 0.5328 | 0.0000 | |
| GSE63941 | MYLK2 | 85366 | 231792_at | 0.0637 | 0.5949 | |
| GSE77861 | MYLK2 | 85366 | 231792_at | -0.1308 | 0.1931 | |
| GSE97050 | MYLK2 | 85366 | A_23_P80008 | -0.0253 | 0.9135 | |
| TCGA | MYLK2 | 85366 | RNAseq | 0.4352 | 0.2254 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MYLK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MYLK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYLK2 | 85366 | 15 | 0 | 15 | |
| GSE20123 | MYLK2 | 85366 | 15 | 0 | 15 | |
| GSE43470 | MYLK2 | 85366 | 11 | 0 | 32 | |
| GSE46452 | MYLK2 | 85366 | 29 | 0 | 30 | |
| GSE47630 | MYLK2 | 85366 | 25 | 0 | 15 | |
| GSE54993 | MYLK2 | 85366 | 0 | 18 | 52 | |
| GSE54994 | MYLK2 | 85366 | 27 | 1 | 25 | |
| GSE60625 | MYLK2 | 85366 | 0 | 0 | 11 | |
| GSE74703 | MYLK2 | 85366 | 10 | 0 | 26 | |
| GSE74704 | MYLK2 | 85366 | 10 | 0 | 10 | |
| TCGA | MYLK2 | 85366 | 49 | 1 | 46 |
Total number of gains: 191; Total number of losses: 20; Total Number of normals: 277.
Somatic mutations of MYLK2:
Generating mutation plots.
Highly correlated genes for MYLK2:
Showing top 20/364 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYLK2 | TERT | 0.770469 | 3 | 0 | 3 |
| MYLK2 | SHD | 0.769718 | 3 | 0 | 3 |
| MYLK2 | OR7D4 | 0.761006 | 3 | 0 | 3 |
| MYLK2 | MS4A18 | 0.75116 | 3 | 0 | 3 |
| MYLK2 | ADAMTS7 | 0.74185 | 3 | 0 | 3 |
| MYLK2 | NTNG2 | 0.735217 | 3 | 0 | 3 |
| MYLK2 | CCDC42 | 0.733723 | 4 | 0 | 4 |
| MYLK2 | RFX8 | 0.733139 | 3 | 0 | 3 |
| MYLK2 | IL23A | 0.728151 | 3 | 0 | 3 |
| MYLK2 | OR10W1 | 0.716055 | 3 | 0 | 3 |
| MYLK2 | SHISA7 | 0.712537 | 4 | 0 | 3 |
| MYLK2 | OR2G2 | 0.711365 | 3 | 0 | 3 |
| MYLK2 | PSMB11 | 0.710329 | 3 | 0 | 3 |
| MYLK2 | MRGPRG | 0.709615 | 3 | 0 | 3 |
| MYLK2 | NPM2 | 0.706964 | 5 | 0 | 5 |
| MYLK2 | CALCA | 0.703597 | 3 | 0 | 3 |
| MYLK2 | TBC1D10B | 0.700741 | 3 | 0 | 3 |
| MYLK2 | ZBTB45 | 0.699572 | 3 | 0 | 3 |
| MYLK2 | VWA5B2 | 0.696523 | 5 | 0 | 5 |
| MYLK2 | TMEM89 | 0.694161 | 3 | 0 | 3 |
For details and further investigation, click here
