| Full name: MAF bZIP transcription factor A | Alias Symbol: RIPE3b1|hMafA | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 389692 | HGNC ID: HGNC:23145 | Ensembl Gene: ENSG00000182759 | OMIM ID: 610303 |
| Drug and gene relationship at DGIdb | |||
MAFA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04930 | Type II diabetes mellitus | |
| hsa04950 | Maturity onset diabetes of the young |
Expression of MAFA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | MAFA | 389692 | 22778 | -0.0677 | 0.2179 | |
| GSE53624 | MAFA | 389692 | 22778 | -0.0212 | 0.7401 | |
| GSE97050 | MAFA | 389692 | A_24_P127719 | 0.0627 | 0.7698 | |
| SRP159526 | MAFA | 389692 | RNAseq | 2.8570 | 0.0001 | |
| TCGA | MAFA | 389692 | RNAseq | 1.3830 | 0.0107 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by MAFA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAFA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAFA | 389692 | 17 | 1 | 12 | |
| GSE20123 | MAFA | 389692 | 17 | 1 | 12 | |
| GSE43470 | MAFA | 389692 | 17 | 2 | 24 | |
| GSE46452 | MAFA | 389692 | 27 | 0 | 32 | |
| GSE47630 | MAFA | 389692 | 23 | 1 | 16 | |
| GSE54993 | MAFA | 389692 | 0 | 25 | 45 | |
| GSE54994 | MAFA | 389692 | 39 | 1 | 13 | |
| GSE60625 | MAFA | 389692 | 3 | 4 | 4 | |
| GSE74703 | MAFA | 389692 | 15 | 1 | 20 | |
| GSE74704 | MAFA | 389692 | 10 | 0 | 10 | |
| TCGA | MAFA | 389692 | 64 | 2 | 30 |
Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.
Somatic mutations of MAFA:
Generating mutation plots.
Highly correlated genes for MAFA:
Showing top 20/22 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAFA | PPA2 | 0.815166 | 3 | 0 | 3 |
| MAFA | ANKRD33 | 0.780478 | 3 | 0 | 3 |
| MAFA | C11orf21 | 0.780295 | 3 | 0 | 3 |
| MAFA | EVX1 | 0.754332 | 3 | 0 | 3 |
| MAFA | ZNF329 | 0.749441 | 3 | 0 | 3 |
| MAFA | KLRG2 | 0.744585 | 3 | 0 | 3 |
| MAFA | GPR150 | 0.740314 | 3 | 0 | 3 |
| MAFA | RNF32 | 0.737678 | 3 | 0 | 3 |
| MAFA | C8G | 0.728119 | 3 | 0 | 3 |
| MAFA | MEX3D | 0.727399 | 3 | 0 | 3 |
| MAFA | ADAMTS7 | 0.727198 | 3 | 0 | 3 |
| MAFA | SCARF2 | 0.712774 | 3 | 0 | 3 |
| MAFA | SLC22A7 | 0.699096 | 3 | 0 | 3 |
| MAFA | FGFR4 | 0.698605 | 3 | 0 | 3 |
| MAFA | C20orf141 | 0.695944 | 3 | 0 | 3 |
| MAFA | ZC3H10 | 0.69008 | 3 | 0 | 3 |
| MAFA | SALL3 | 0.684434 | 3 | 0 | 3 |
| MAFA | RHBG | 0.674722 | 3 | 0 | 3 |
| MAFA | SP8 | 0.657036 | 3 | 0 | 3 |
| MAFA | ZNF205 | 0.656556 | 3 | 0 | 3 |
For details and further investigation, click here
