| Full name: cadherin 2 | Alias Symbol: CDHN|CD325 | ||
| Type: protein-coding gene | Cytoband: 18q12.1 | ||
| Entrez ID: 1000 | HGNC ID: HGNC:1759 | Ensembl Gene: ENSG00000170558 | OMIM ID: 114020 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CDH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDH2 | 1000 | 203441_s_at | -0.1725 | 0.7927 | |
| GSE20347 | CDH2 | 1000 | 203441_s_at | -0.0608 | 0.4036 | |
| GSE23400 | CDH2 | 1000 | 203441_s_at | -0.0410 | 0.3831 | |
| GSE26886 | CDH2 | 1000 | 203441_s_at | 0.4219 | 0.0009 | |
| GSE29001 | CDH2 | 1000 | 203441_s_at | -0.0350 | 0.8037 | |
| GSE38129 | CDH2 | 1000 | 203440_at | -0.2279 | 0.6268 | |
| GSE45670 | CDH2 | 1000 | 203440_at | -0.2090 | 0.6364 | |
| GSE53622 | CDH2 | 1000 | 40093 | 0.1463 | 0.1719 | |
| GSE53624 | CDH2 | 1000 | 40093 | 0.5751 | 0.0000 | |
| GSE63941 | CDH2 | 1000 | 203440_at | -3.2866 | 0.0313 | |
| GSE77861 | CDH2 | 1000 | 203441_s_at | 0.0931 | 0.6181 | |
| GSE97050 | CDH2 | 1000 | A_23_P38732 | -0.1452 | 0.6681 | |
| SRP007169 | CDH2 | 1000 | RNAseq | 5.4363 | 0.0000 | |
| SRP064894 | CDH2 | 1000 | RNAseq | 2.3739 | 0.0000 | |
| SRP133303 | CDH2 | 1000 | RNAseq | 2.1587 | 0.0001 | |
| SRP159526 | CDH2 | 1000 | RNAseq | 2.4559 | 0.0185 | |
| SRP219564 | CDH2 | 1000 | RNAseq | 1.6112 | 0.1788 | |
| TCGA | CDH2 | 1000 | RNAseq | -1.1999 | 0.0001 |
Upregulated datasets: 4; Downregulated datasets: 2.
Survival by CDH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDH2 | 1000 | 1 | 7 | 22 | |
| GSE20123 | CDH2 | 1000 | 1 | 8 | 21 | |
| GSE43470 | CDH2 | 1000 | 0 | 2 | 41 | |
| GSE46452 | CDH2 | 1000 | 1 | 25 | 33 | |
| GSE47630 | CDH2 | 1000 | 5 | 20 | 15 | |
| GSE54993 | CDH2 | 1000 | 7 | 1 | 62 | |
| GSE54994 | CDH2 | 1000 | 3 | 14 | 36 | |
| GSE60625 | CDH2 | 1000 | 0 | 4 | 7 | |
| GSE74703 | CDH2 | 1000 | 0 | 2 | 34 | |
| GSE74704 | CDH2 | 1000 | 0 | 7 | 13 | |
| TCGA | CDH2 | 1000 | 16 | 32 | 48 |
Total number of gains: 34; Total number of losses: 122; Total Number of normals: 332.
Somatic mutations of CDH2:
Generating mutation plots.
Highly correlated genes for CDH2:
Showing top 20/323 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDH2 | S100A4 | 0.788276 | 3 | 0 | 3 |
| CDH2 | TUBA8 | 0.766418 | 3 | 0 | 3 |
| CDH2 | ADAMTS7 | 0.764855 | 3 | 0 | 3 |
| CDH2 | BMP10 | 0.758814 | 3 | 0 | 3 |
| CDH2 | FXYD2 | 0.745498 | 3 | 0 | 3 |
| CDH2 | ZNF511 | 0.74177 | 3 | 0 | 3 |
| CDH2 | PPP1R12C | 0.732573 | 3 | 0 | 3 |
| CDH2 | SHARPIN | 0.729191 | 4 | 0 | 4 |
| CDH2 | RHBDL1 | 0.727102 | 3 | 0 | 3 |
| CDH2 | CALCR | 0.725574 | 3 | 0 | 3 |
| CDH2 | SHH | 0.725332 | 3 | 0 | 3 |
| CDH2 | IGFL2 | 0.723669 | 3 | 0 | 3 |
| CDH2 | RAX2 | 0.717229 | 3 | 0 | 3 |
| CDH2 | TCTE1 | 0.710253 | 3 | 0 | 3 |
| CDH2 | LRTM1 | 0.688621 | 3 | 0 | 3 |
| CDH2 | CHD5 | 0.684635 | 7 | 0 | 5 |
| CDH2 | MUC8 | 0.68305 | 4 | 0 | 4 |
| CDH2 | GPR88 | 0.681579 | 8 | 0 | 6 |
| CDH2 | TMEM229A | 0.680144 | 3 | 0 | 3 |
| CDH2 | KIF17 | 0.679493 | 3 | 0 | 3 |
For details and further investigation, click here
