ADAP2

 

Full name: ArfGAP with dual PH domains 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 17q11.2
Entrez ID: 55803 HGNC ID: HGNC:16487 Ensembl Gene: ENSG00000184060 OMIM ID: 608635
Drug and gene relationship at DGIdb

 

Expression of ADAP2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADAP2 55803 219358_s_at 1.0532 0.1492
GSE20347 ADAP2 55803 219358_s_at 0.6595 0.0003
GSE23400 ADAP2 55803 219358_s_at 0.5128 0.0000
GSE26886 ADAP2 55803 219358_s_at 0.9596 0.0002
GSE29001 ADAP2 55803 219358_s_at 0.8167 0.0136
GSE38129 ADAP2 55803 219358_s_at 0.6417 0.0000
GSE45670 ADAP2 55803 219358_s_at 0.8459 0.0041
GSE53622 ADAP2 55803 24877 0.4976 0.0000
GSE53624 ADAP2 55803 24877 0.6071 0.0000
GSE63941 ADAP2 55803 219358_s_at 0.0046 0.9945
GSE77861 ADAP2 55803 222876_s_at 0.2764 0.1376
GSE97050 ADAP2 55803 A_23_P49816 0.5060 0.2729
SRP007169 ADAP2 55803 RNAseq 0.9735 0.0596
SRP008496 ADAP2 55803 RNAseq 0.7926 0.0468
SRP064894 ADAP2 55803 RNAseq 1.3100 0.0000
SRP133303 ADAP2 55803 RNAseq 0.4928 0.0263
SRP159526 ADAP2 55803 RNAseq 1.0821 0.0515
SRP193095 ADAP2 55803 RNAseq 0.6804 0.0000
SRP219564 ADAP2 55803 RNAseq 0.8371 0.0980
TCGA ADAP2 55803 RNAseq 0.4139 0.0009

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ADAP2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADAP2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADAP2 55803 8 2 20
GSE20123 ADAP2 55803 9 2 19
GSE43470 ADAP2 55803 0 1 42
GSE46452 ADAP2 55803 33 1 25
GSE47630 ADAP2 55803 7 1 32
GSE54993 ADAP2 55803 2 3 65
GSE54994 ADAP2 55803 7 6 40
GSE60625 ADAP2 55803 4 0 7
GSE74703 ADAP2 55803 0 1 35
GSE74704 ADAP2 55803 6 2 12
TCGA ADAP2 55803 19 10 67

Total number of gains: 95; Total number of losses: 29; Total Number of normals: 364.  

 

Somatic mutations of ADAP2:

 

Generating mutation plots.

 

Highly correlated genes for ADAP2:

 

Showing top 20/956 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADAP2IPO40.720883303
ADAP2C18orf540.720356303
ADAP2RILPL20.710949303
ADAP2FAF20.706021303
ADAP2ZGPAT0.695761303
ADAP2EME10.686993504
ADAP2LARP10.686688303
ADAP2SCYL10.685507404
ADAP2IFRD20.681185303
ADAP2LRRC250.675155404
ADAP2RBMS10.671702303
ADAP2SIPA10.671192303
ADAP2MRPL500.666492303
ADAP2KLHL130.665938303
ADAP2YWHAG0.665727404
ADAP2DDX100.665057303
ADAP2FAM169A0.664334504
ADAP2TMEM167A0.6633303
ADAP2RPL26L10.662076403
ADAP2ELOVL70.659005403

For details and further investigation, click here