| Full name: mitochondrial ribosomal protein L50 | Alias Symbol: FLJ20493|MRP-L50 | ||
| Type: protein-coding gene | Cytoband: 9q31.1 | ||
| Entrez ID: 54534 | HGNC ID: HGNC:16654 | Ensembl Gene: ENSG00000136897 | OMIM ID: 611854 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of MRPL50:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPL50 | 54534 | 225581_s_at | 0.3830 | 0.2665 | |
| GSE26886 | MRPL50 | 54534 | 225581_s_at | 1.0595 | 0.0000 | |
| GSE45670 | MRPL50 | 54534 | 225581_s_at | 0.4301 | 0.0249 | |
| GSE53622 | MRPL50 | 54534 | 127 | 0.3139 | 0.0000 | |
| GSE53624 | MRPL50 | 54534 | 127 | 0.6867 | 0.0000 | |
| GSE63941 | MRPL50 | 54534 | 225581_s_at | 0.4657 | 0.2742 | |
| GSE77861 | MRPL50 | 54534 | 225581_s_at | 0.3645 | 0.2564 | |
| GSE97050 | MRPL50 | 54534 | A_23_P253412 | -0.0372 | 0.9204 | |
| SRP007169 | MRPL50 | 54534 | RNAseq | 0.8924 | 0.0911 | |
| SRP008496 | MRPL50 | 54534 | RNAseq | 0.7777 | 0.0088 | |
| SRP064894 | MRPL50 | 54534 | RNAseq | 0.3963 | 0.0157 | |
| SRP133303 | MRPL50 | 54534 | RNAseq | 0.2545 | 0.0808 | |
| SRP159526 | MRPL50 | 54534 | RNAseq | 0.2916 | 0.1456 | |
| SRP193095 | MRPL50 | 54534 | RNAseq | -0.0722 | 0.6304 | |
| SRP219564 | MRPL50 | 54534 | RNAseq | 0.1930 | 0.4524 | |
| TCGA | MRPL50 | 54534 | RNAseq | 0.0517 | 0.4199 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MRPL50 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPL50:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPL50 | 54534 | 4 | 10 | 16 | |
| GSE20123 | MRPL50 | 54534 | 5 | 9 | 16 | |
| GSE43470 | MRPL50 | 54534 | 6 | 3 | 34 | |
| GSE46452 | MRPL50 | 54534 | 6 | 13 | 40 | |
| GSE47630 | MRPL50 | 54534 | 1 | 17 | 22 | |
| GSE54993 | MRPL50 | 54534 | 3 | 3 | 64 | |
| GSE54994 | MRPL50 | 54534 | 9 | 11 | 33 | |
| GSE60625 | MRPL50 | 54534 | 0 | 0 | 11 | |
| GSE74703 | MRPL50 | 54534 | 5 | 3 | 28 | |
| GSE74704 | MRPL50 | 54534 | 2 | 6 | 12 | |
| TCGA | MRPL50 | 54534 | 28 | 21 | 47 |
Total number of gains: 69; Total number of losses: 96; Total Number of normals: 323.
Somatic mutations of MRPL50:
Generating mutation plots.
Highly correlated genes for MRPL50:
Showing top 20/876 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPL50 | PHOSPHO2 | 0.781677 | 3 | 0 | 3 |
| MRPL50 | UBXN2A | 0.760855 | 3 | 0 | 3 |
| MRPL50 | KRTCAP2 | 0.753737 | 3 | 0 | 3 |
| MRPL50 | ORC4 | 0.748452 | 5 | 0 | 4 |
| MRPL50 | PSMD7 | 0.748048 | 3 | 0 | 3 |
| MRPL50 | NUP43 | 0.747129 | 4 | 0 | 4 |
| MRPL50 | SLC5A3 | 0.740003 | 3 | 0 | 3 |
| MRPL50 | CYCS | 0.736761 | 5 | 0 | 5 |
| MRPL50 | ZNF808 | 0.734853 | 3 | 0 | 3 |
| MRPL50 | TMTC3 | 0.722621 | 4 | 0 | 4 |
| MRPL50 | HSF2 | 0.71339 | 3 | 0 | 3 |
| MRPL50 | NIPA2 | 0.712471 | 4 | 0 | 3 |
| MRPL50 | ADCY3 | 0.709127 | 3 | 0 | 3 |
| MRPL50 | DGKH | 0.708359 | 4 | 0 | 3 |
| MRPL50 | TPCN2 | 0.708311 | 3 | 0 | 3 |
| MRPL50 | NUMBL | 0.705592 | 3 | 0 | 3 |
| MRPL50 | EIF3J | 0.705019 | 3 | 0 | 3 |
| MRPL50 | RRAS2 | 0.702212 | 4 | 0 | 4 |
| MRPL50 | TTBK2 | 0.69825 | 3 | 0 | 3 |
| MRPL50 | DERA | 0.697888 | 3 | 0 | 3 |
For details and further investigation, click here
