| Full name: DEAD-box helicase 10 | Alias Symbol: HRH-J8|Dbp4 | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 1662 | HGNC ID: HGNC:2735 | Ensembl Gene: ENSG00000178105 | OMIM ID: 601235 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDX10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX10 | 1662 | 204977_at | 0.4265 | 0.0962 | |
| GSE20347 | DDX10 | 1662 | 204977_at | 0.3629 | 0.0291 | |
| GSE23400 | DDX10 | 1662 | 204977_at | 0.4370 | 0.0000 | |
| GSE26886 | DDX10 | 1662 | 204977_at | 1.2696 | 0.0007 | |
| GSE29001 | DDX10 | 1662 | 204977_at | 0.2491 | 0.2961 | |
| GSE38129 | DDX10 | 1662 | 204977_at | 0.3257 | 0.0054 | |
| GSE45670 | DDX10 | 1662 | 204977_at | 0.2163 | 0.2831 | |
| GSE53622 | DDX10 | 1662 | 89694 | 0.3548 | 0.0000 | |
| GSE53624 | DDX10 | 1662 | 89694 | 0.6284 | 0.0000 | |
| GSE63941 | DDX10 | 1662 | 204977_at | 0.0135 | 0.9820 | |
| GSE77861 | DDX10 | 1662 | 204977_at | 0.7098 | 0.0206 | |
| GSE97050 | DDX10 | 1662 | A_23_P32938 | 0.3363 | 0.3720 | |
| SRP007169 | DDX10 | 1662 | RNAseq | 0.6206 | 0.1592 | |
| SRP008496 | DDX10 | 1662 | RNAseq | 0.6830 | 0.0349 | |
| SRP064894 | DDX10 | 1662 | RNAseq | 0.2451 | 0.1101 | |
| SRP133303 | DDX10 | 1662 | RNAseq | 0.2233 | 0.1320 | |
| SRP159526 | DDX10 | 1662 | RNAseq | 0.4821 | 0.2385 | |
| SRP193095 | DDX10 | 1662 | RNAseq | -0.0620 | 0.6028 | |
| SRP219564 | DDX10 | 1662 | RNAseq | 0.3233 | 0.3094 | |
| TCGA | DDX10 | 1662 | RNAseq | 0.1414 | 0.0254 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DDX10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX10 | 1662 | 0 | 13 | 17 | |
| GSE20123 | DDX10 | 1662 | 0 | 13 | 17 | |
| GSE43470 | DDX10 | 1662 | 2 | 6 | 35 | |
| GSE46452 | DDX10 | 1662 | 3 | 26 | 30 | |
| GSE47630 | DDX10 | 1662 | 2 | 19 | 19 | |
| GSE54993 | DDX10 | 1662 | 9 | 1 | 60 | |
| GSE54994 | DDX10 | 1662 | 5 | 19 | 29 | |
| GSE60625 | DDX10 | 1662 | 0 | 3 | 8 | |
| GSE74703 | DDX10 | 1662 | 1 | 4 | 31 | |
| GSE74704 | DDX10 | 1662 | 0 | 9 | 11 | |
| TCGA | DDX10 | 1662 | 6 | 48 | 42 |
Total number of gains: 28; Total number of losses: 161; Total Number of normals: 299.
Somatic mutations of DDX10:
Generating mutation plots.
Highly correlated genes for DDX10:
Showing top 20/1371 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX10 | WDR75 | 0.768139 | 4 | 0 | 3 |
| DDX10 | PPP1R35 | 0.767185 | 4 | 0 | 4 |
| DDX10 | ARHGAP19 | 0.76301 | 3 | 0 | 3 |
| DDX10 | C5orf22 | 0.758926 | 3 | 0 | 3 |
| DDX10 | PIF1 | 0.755351 | 4 | 0 | 3 |
| DDX10 | MCM3AP | 0.749814 | 3 | 0 | 3 |
| DDX10 | TMEM170A | 0.741422 | 3 | 0 | 3 |
| DDX10 | SGTB | 0.741296 | 3 | 0 | 3 |
| DDX10 | CWF19L1 | 0.737074 | 4 | 0 | 4 |
| DDX10 | EEFSEC | 0.72177 | 3 | 0 | 3 |
| DDX10 | TIGD1 | 0.717803 | 3 | 0 | 3 |
| DDX10 | ZFHX3 | 0.716143 | 3 | 0 | 3 |
| DDX10 | SENP1 | 0.710943 | 3 | 0 | 3 |
| DDX10 | WDR72 | 0.703809 | 3 | 0 | 3 |
| DDX10 | ATP11C | 0.701963 | 4 | 0 | 3 |
| DDX10 | CHST3 | 0.700879 | 3 | 0 | 3 |
| DDX10 | PPP2R2D | 0.693322 | 3 | 0 | 3 |
| DDX10 | METAP1D | 0.691857 | 4 | 0 | 3 |
| DDX10 | POLA1 | 0.688494 | 5 | 0 | 4 |
| DDX10 | ECSIT | 0.687147 | 4 | 0 | 4 |
For details and further investigation, click here
