| Full name: essential meiotic structure-specific endonuclease 1 | Alias Symbol: FLJ31364|MMS4L|SLX2A | ||
| Type: protein-coding gene | Cytoband: 17q21.33 | ||
| Entrez ID: 146956 | HGNC ID: HGNC:24965 | Ensembl Gene: ENSG00000154920 | OMIM ID: 610885 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EME1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EME1 | 146956 | 234464_s_at | 1.0045 | 0.0800 | |
| GSE26886 | EME1 | 146956 | 234464_s_at | 1.5534 | 0.0000 | |
| GSE45670 | EME1 | 146956 | 234464_s_at | 1.0794 | 0.0000 | |
| GSE63941 | EME1 | 146956 | 234464_s_at | 0.8849 | 0.0008 | |
| GSE77861 | EME1 | 146956 | 234465_at | 0.2690 | 0.0249 | |
| GSE97050 | EME1 | 146956 | A_23_P368225 | 0.5796 | 0.2151 | |
| SRP007169 | EME1 | 146956 | RNAseq | 2.3750 | 0.0097 | |
| SRP064894 | EME1 | 146956 | RNAseq | 1.8825 | 0.0000 | |
| SRP133303 | EME1 | 146956 | RNAseq | 2.0148 | 0.0000 | |
| SRP159526 | EME1 | 146956 | RNAseq | 2.4154 | 0.0000 | |
| SRP193095 | EME1 | 146956 | RNAseq | 1.2336 | 0.0000 | |
| SRP219564 | EME1 | 146956 | RNAseq | 2.0317 | 0.0003 | |
| TCGA | EME1 | 146956 | RNAseq | 1.3656 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by EME1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of EME1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EME1 | 146956 | 5 | 2 | 23 | |
| GSE20123 | EME1 | 146956 | 5 | 2 | 23 | |
| GSE43470 | EME1 | 146956 | 3 | 2 | 38 | |
| GSE46452 | EME1 | 146956 | 32 | 0 | 27 | |
| GSE47630 | EME1 | 146956 | 9 | 0 | 31 | |
| GSE54993 | EME1 | 146956 | 2 | 4 | 64 | |
| GSE54994 | EME1 | 146956 | 9 | 6 | 38 | |
| GSE60625 | EME1 | 146956 | 4 | 0 | 7 | |
| GSE74703 | EME1 | 146956 | 3 | 2 | 31 | |
| GSE74704 | EME1 | 146956 | 4 | 1 | 15 | |
| TCGA | EME1 | 146956 | 27 | 7 | 62 |
Total number of gains: 103; Total number of losses: 26; Total Number of normals: 359.
Somatic mutations of EME1:
Generating mutation plots.
Highly correlated genes for EME1:
Showing top 20/1707 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EME1 | GINS4 | 0.833553 | 4 | 0 | 4 |
| EME1 | ORC6 | 0.828683 | 5 | 0 | 5 |
| EME1 | SNRPG | 0.810573 | 6 | 0 | 6 |
| EME1 | VRK1 | 0.806282 | 5 | 0 | 5 |
| EME1 | CCNA2 | 0.798959 | 5 | 0 | 5 |
| EME1 | TMEM223 | 0.797845 | 5 | 0 | 5 |
| EME1 | CENPN | 0.797543 | 6 | 0 | 6 |
| EME1 | MYBL2 | 0.795249 | 6 | 0 | 6 |
| EME1 | WDHD1 | 0.794269 | 6 | 0 | 6 |
| EME1 | PSMG3 | 0.791927 | 5 | 0 | 5 |
| EME1 | BIRC5 | 0.788251 | 6 | 0 | 6 |
| EME1 | EPHB4 | 0.782465 | 5 | 0 | 5 |
| EME1 | GINS1 | 0.777145 | 6 | 0 | 6 |
| EME1 | PSME4 | 0.775331 | 5 | 0 | 5 |
| EME1 | CDCA2 | 0.770292 | 6 | 0 | 6 |
| EME1 | ADAM17 | 0.769989 | 5 | 0 | 4 |
| EME1 | HPRT1 | 0.767661 | 5 | 0 | 5 |
| EME1 | USB1 | 0.766666 | 4 | 0 | 4 |
| EME1 | TMX1 | 0.766485 | 3 | 0 | 3 |
| EME1 | IGF2BP2 | 0.765788 | 5 | 0 | 5 |
For details and further investigation, click here
