C18orf54

 

Full name: chromosome 18 open reading frame 54 Alias Symbol: MGC33382|LAS2
Type: protein-coding gene Cytoband: 18q21.2
Entrez ID: 162681 HGNC ID: HGNC:13796 Ensembl Gene: ENSG00000166845 OMIM ID: 613258
Drug and gene relationship at DGIdb

 

Expression of C18orf54:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 C18orf54 162681 229442_at 1.1770 0.1544
GSE26886 C18orf54 162681 229442_at 0.1902 0.5664
GSE45670 C18orf54 162681 229442_at 0.9611 0.0002
GSE53622 C18orf54 162681 57353 1.0699 0.0000
GSE53624 C18orf54 162681 57353 1.3798 0.0000
GSE63941 C18orf54 162681 229442_at 0.2214 0.7406
GSE77861 C18orf54 162681 229442_at 0.6691 0.0112
GSE97050 C18orf54 162681 A_32_P162374 0.6641 0.1065
SRP007169 C18orf54 162681 RNAseq 2.2067 0.0008
SRP008496 C18orf54 162681 RNAseq 2.1730 0.0001
SRP064894 C18orf54 162681 RNAseq 1.5215 0.0000
SRP133303 C18orf54 162681 RNAseq 1.3043 0.0000
SRP159526 C18orf54 162681 RNAseq 1.2258 0.0003
SRP193095 C18orf54 162681 RNAseq 0.9802 0.0000
SRP219564 C18orf54 162681 RNAseq 0.5609 0.1922
TCGA C18orf54 162681 RNAseq 0.7342 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by C18orf54 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of C18orf54:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 C18orf54 162681 1 9 20
GSE20123 C18orf54 162681 1 9 20
GSE43470 C18orf54 162681 0 5 38
GSE46452 C18orf54 162681 1 26 32
GSE47630 C18orf54 162681 5 20 15
GSE54993 C18orf54 162681 10 0 60
GSE54994 C18orf54 162681 2 16 35
GSE60625 C18orf54 162681 0 4 7
GSE74703 C18orf54 162681 0 5 31
GSE74704 C18orf54 162681 1 6 13
TCGA C18orf54 162681 10 43 43

Total number of gains: 31; Total number of losses: 143; Total Number of normals: 314.  

 

Somatic mutations of C18orf54:

 

Generating mutation plots.

 

Highly correlated genes for C18orf54:

 

Showing top 20/1382 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
C18orf54CXXC10.840182303
C18orf54KDSR0.806699303
C18orf54MCM80.805295606
C18orf54CLP10.779645303
C18orf54MMS22L0.767349303
C18orf54POLR3F0.766109505
C18orf54FADS10.760716303
C18orf54RCN10.760225404
C18orf54PPP1CC0.756466303
C18orf54CHML0.752978505
C18orf54MAD2L20.752236404
C18orf54UHRF1BP10.749349303
C18orf54PPTC70.746493303
C18orf54SPNS10.746484404
C18orf54TRAF70.746382404
C18orf54CCDC1170.742309303
C18orf54SLC39A60.741595606
C18orf54TYMS0.739891404
C18orf54AKR1B10.739389403
C18orf54GNG100.733263303

For details and further investigation, click here