IPO4

 

Full name: importin 4 Alias Symbol: Imp4|FLJ23338
Type: protein-coding gene Cytoband: 14q12
Entrez ID: 79711 HGNC ID: HGNC:19426 Ensembl Gene: ENSG00000196497 OMIM ID: 
Drug and gene relationship at DGIdb

 

Expression of IPO4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IPO4 79711 218305_at 0.7602 0.2653
GSE20347 IPO4 79711 218305_at 0.4466 0.0549
GSE23400 IPO4 79711 218305_at 0.2771 0.0008
GSE26886 IPO4 79711 218305_at 1.0887 0.0000
GSE29001 IPO4 79711 218305_at 0.3238 0.3039
GSE38129 IPO4 79711 218305_at 0.6498 0.0012
GSE45670 IPO4 79711 218305_at 0.3140 0.2020
GSE53622 IPO4 79711 4713 0.3625 0.0145
GSE53624 IPO4 79711 4713 0.5549 0.0000
GSE63941 IPO4 79711 218305_at 0.5606 0.3438
GSE77861 IPO4 79711 218305_at 0.2605 0.2356
GSE97050 IPO4 79711 A_23_P162970 1.0197 0.1356
SRP007169 IPO4 79711 RNAseq 1.1251 0.0215
SRP008496 IPO4 79711 RNAseq 0.8610 0.0163
SRP064894 IPO4 79711 RNAseq 0.4571 0.0269
SRP133303 IPO4 79711 RNAseq 0.7043 0.0008
SRP159526 IPO4 79711 RNAseq 0.5811 0.0185
SRP193095 IPO4 79711 RNAseq 0.5469 0.0002
SRP219564 IPO4 79711 RNAseq 0.6004 0.2016
TCGA IPO4 79711 RNAseq 0.2320 0.0003

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by IPO4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IPO4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IPO4 79711 8 3 19
GSE20123 IPO4 79711 8 3 19
GSE43470 IPO4 79711 8 2 33
GSE46452 IPO4 79711 16 2 41
GSE47630 IPO4 79711 11 10 19
GSE54993 IPO4 79711 3 11 56
GSE54994 IPO4 79711 18 5 30
GSE60625 IPO4 79711 0 2 9
GSE74703 IPO4 79711 7 2 27
GSE74704 IPO4 79711 3 2 15
TCGA IPO4 79711 27 13 56

Total number of gains: 109; Total number of losses: 55; Total Number of normals: 324.  

 

Somatic mutations of IPO4:

 

Generating mutation plots.

 

Highly correlated genes for IPO4:

 

Showing top 20/1310 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IPO4COX160.760077303
IPO4TMEM2230.734469504
IPO4BNC10.730783403
IPO4OCIAD20.724779403
IPO4ADAP20.720883303
IPO4MRPL520.71485311010
IPO4PGM2L10.714771303
IPO4ALKBH60.71346303
IPO4NEK80.712906303
IPO4ASCL20.712366303
IPO4GLI30.710576303
IPO4UBE2E30.706971504
IPO4SEMA3C0.704359303
IPO4RLIM0.703225303
IPO4MAP3K110.696463504
IPO4NLN0.695843403
IPO4MTRR0.694159303
IPO4FANCM0.692756504
IPO4NFKB20.692484303
IPO4BASP10.690138403

For details and further investigation, click here