| Full name: adrenomedullin | Alias Symbol: AM | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 133 | HGNC ID: HGNC:259 | Ensembl Gene: ENSG00000148926 | OMIM ID: 103275 |
| Drug and gene relationship at DGIdb | |||
Expression of ADM:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADM | 133 | 202912_at | -0.5657 | 0.6514 | |
| GSE20347 | ADM | 133 | 202912_at | 0.3345 | 0.3788 | |
| GSE23400 | ADM | 133 | 202912_at | -0.1233 | 0.5089 | |
| GSE26886 | ADM | 133 | 202912_at | 0.4310 | 0.2154 | |
| GSE29001 | ADM | 133 | 202912_at | -0.3421 | 0.5457 | |
| GSE38129 | ADM | 133 | 202912_at | 0.3204 | 0.4367 | |
| GSE45670 | ADM | 133 | 202912_at | 0.0901 | 0.8383 | |
| GSE53622 | ADM | 133 | 9647 | 0.1066 | 0.4225 | |
| GSE53624 | ADM | 133 | 9647 | 0.1116 | 0.2622 | |
| GSE63941 | ADM | 133 | 202912_at | -2.0366 | 0.0335 | |
| GSE77861 | ADM | 133 | 202912_at | 0.5804 | 0.3605 | |
| GSE97050 | ADM | 133 | A_23_P127948 | -0.2080 | 0.6443 | |
| SRP007169 | ADM | 133 | RNAseq | -1.3914 | 0.0350 | |
| SRP008496 | ADM | 133 | RNAseq | -0.7188 | 0.0981 | |
| SRP064894 | ADM | 133 | RNAseq | -0.2940 | 0.3561 | |
| SRP133303 | ADM | 133 | RNAseq | 0.3596 | 0.3365 | |
| SRP159526 | ADM | 133 | RNAseq | 0.2917 | 0.6748 | |
| SRP193095 | ADM | 133 | RNAseq | 0.6191 | 0.0508 | |
| SRP219564 | ADM | 133 | RNAseq | 1.2178 | 0.0314 | |
| TCGA | ADM | 133 | RNAseq | 0.4144 | 0.0017 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by ADM expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADM:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADM | 133 | 0 | 9 | 21 | |
| GSE20123 | ADM | 133 | 0 | 10 | 20 | |
| GSE43470 | ADM | 133 | 1 | 6 | 36 | |
| GSE46452 | ADM | 133 | 7 | 5 | 47 | |
| GSE47630 | ADM | 133 | 3 | 11 | 26 | |
| GSE54993 | ADM | 133 | 3 | 1 | 66 | |
| GSE54994 | ADM | 133 | 3 | 12 | 38 | |
| GSE60625 | ADM | 133 | 0 | 0 | 11 | |
| GSE74703 | ADM | 133 | 1 | 4 | 31 | |
| GSE74704 | ADM | 133 | 0 | 7 | 13 | |
| TCGA | ADM | 133 | 12 | 34 | 50 |
Total number of gains: 30; Total number of losses: 99; Total Number of normals: 359.
Somatic mutations of ADM:
Generating mutation plots.
Highly correlated genes for ADM:
Showing top 20/28 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADM | PCSK4 | 0.655728 | 3 | 0 | 3 |
| ADM | PLA2G12B | 0.644328 | 3 | 0 | 3 |
| ADM | LINC01121 | 0.637798 | 3 | 0 | 3 |
| ADM | C9orf131 | 0.618292 | 3 | 0 | 3 |
| ADM | FMR1NB | 0.608553 | 3 | 0 | 3 |
| ADM | TUBB3 | 0.573227 | 3 | 0 | 3 |
| ADM | NYAP2 | 0.568619 | 3 | 0 | 3 |
| ADM | CSNK1E | 0.568044 | 4 | 0 | 3 |
| ADM | MAP3K10 | 0.559663 | 3 | 0 | 3 |
| ADM | TSKU | 0.55617 | 4 | 0 | 3 |
| ADM | GRM1 | 0.553386 | 3 | 0 | 3 |
| ADM | PIP5KL1 | 0.544923 | 4 | 0 | 3 |
| ADM | FOXL1 | 0.541585 | 4 | 0 | 3 |
| ADM | KISS1R | 0.538554 | 3 | 0 | 3 |
| ADM | CELF3 | 0.536402 | 4 | 0 | 3 |
| ADM | TOR4A | 0.536381 | 3 | 0 | 3 |
| ADM | RAP2B | 0.532168 | 6 | 0 | 5 |
| ADM | KCTD11 | 0.52598 | 6 | 0 | 3 |
| ADM | RAP1GAP | 0.525073 | 4 | 0 | 3 |
| ADM | P2RY4 | 0.524744 | 4 | 0 | 3 |
For details and further investigation, click here
