| Full name: RAP2B, member of RAS oncogene family | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q25.2 | ||
| Entrez ID: 5912 | HGNC ID: HGNC:9862 | Ensembl Gene: ENSG00000181467 | OMIM ID: 179541 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RAP2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAP2B | 5912 | 213923_at | 0.2596 | 0.5399 | |
| GSE20347 | RAP2B | 5912 | 213923_at | -0.1338 | 0.4144 | |
| GSE23400 | RAP2B | 5912 | 213923_at | 0.0749 | 0.5361 | |
| GSE26886 | RAP2B | 5912 | 213923_at | -1.0157 | 0.0000 | |
| GSE29001 | RAP2B | 5912 | 213923_at | -0.0373 | 0.8663 | |
| GSE38129 | RAP2B | 5912 | 213923_at | 0.2724 | 0.2458 | |
| GSE45670 | RAP2B | 5912 | 213923_at | 0.3267 | 0.0506 | |
| GSE63941 | RAP2B | 5912 | 213923_at | 0.7698 | 0.0703 | |
| GSE77861 | RAP2B | 5912 | 213923_at | 0.2466 | 0.3980 | |
| GSE97050 | RAP2B | 5912 | A_33_P3303121 | -0.1276 | 0.5724 | |
| SRP007169 | RAP2B | 5912 | RNAseq | -0.8861 | 0.0458 | |
| SRP008496 | RAP2B | 5912 | RNAseq | -0.7870 | 0.0021 | |
| SRP064894 | RAP2B | 5912 | RNAseq | -0.0154 | 0.9459 | |
| SRP133303 | RAP2B | 5912 | RNAseq | 0.2004 | 0.4439 | |
| SRP159526 | RAP2B | 5912 | RNAseq | 0.1015 | 0.7032 | |
| SRP193095 | RAP2B | 5912 | RNAseq | -0.0786 | 0.7321 | |
| SRP219564 | RAP2B | 5912 | RNAseq | -0.5901 | 0.3008 | |
| TCGA | RAP2B | 5912 | RNAseq | 0.3564 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RAP2B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of RAP2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAP2B | 5912 | 22 | 0 | 8 | |
| GSE20123 | RAP2B | 5912 | 22 | 0 | 8 | |
| GSE43470 | RAP2B | 5912 | 24 | 0 | 19 | |
| GSE46452 | RAP2B | 5912 | 18 | 2 | 39 | |
| GSE47630 | RAP2B | 5912 | 19 | 3 | 18 | |
| GSE54993 | RAP2B | 5912 | 1 | 10 | 59 | |
| GSE54994 | RAP2B | 5912 | 38 | 1 | 14 | |
| GSE60625 | RAP2B | 5912 | 0 | 6 | 5 | |
| GSE74703 | RAP2B | 5912 | 21 | 0 | 15 | |
| GSE74704 | RAP2B | 5912 | 14 | 0 | 6 | |
| TCGA | RAP2B | 5912 | 73 | 1 | 22 |
Total number of gains: 252; Total number of losses: 23; Total Number of normals: 213.
Somatic mutations of RAP2B:
Generating mutation plots.
Highly correlated genes for RAP2B:
Showing top 20/257 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAP2B | AP1G1 | 0.73616 | 4 | 0 | 4 |
| RAP2B | HIBCH | 0.719617 | 3 | 0 | 3 |
| RAP2B | ALAS1 | 0.712366 | 3 | 0 | 3 |
| RAP2B | STRN3 | 0.706517 | 3 | 0 | 3 |
| RAP2B | FGFR3 | 0.693809 | 3 | 0 | 3 |
| RAP2B | ADCY7 | 0.693537 | 3 | 0 | 3 |
| RAP2B | HPSE | 0.689582 | 3 | 0 | 3 |
| RAP2B | FEM1C | 0.681653 | 3 | 0 | 3 |
| RAP2B | WDR77 | 0.678166 | 3 | 0 | 3 |
| RAP2B | ACSS2 | 0.676587 | 3 | 0 | 3 |
| RAP2B | RASGEF1B | 0.676468 | 3 | 0 | 3 |
| RAP2B | COMMD2 | 0.670516 | 4 | 0 | 3 |
| RAP2B | LINC01121 | 0.67001 | 3 | 0 | 3 |
| RAP2B | MICALCL | 0.665263 | 3 | 0 | 3 |
| RAP2B | MTF1 | 0.663459 | 4 | 0 | 3 |
| RAP2B | CAPZB | 0.662633 | 3 | 0 | 3 |
| RAP2B | ACBD3 | 0.660159 | 5 | 0 | 4 |
| RAP2B | MTHFR | 0.658866 | 3 | 0 | 3 |
| RAP2B | MAP4K5 | 0.657167 | 4 | 0 | 4 |
| RAP2B | ISY1 | 0.655816 | 3 | 0 | 3 |
For details and further investigation, click here
