| Full name: glutamate metabotropic receptor 1 | Alias Symbol: GPRC1A|mGlu1|MGLUR1|PPP1R85 | ||
| Type: protein-coding gene | Cytoband: 6q24.3 | ||
| Entrez ID: 2911 | HGNC ID: HGNC:4593 | Ensembl Gene: ENSG00000152822 | OMIM ID: 604473 |
| Drug and gene relationship at DGIdb | |||
GRM1 involved pathways:
Expression of GRM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRM1 | 2911 | 210940_s_at | 0.0692 | 0.7809 | |
| GSE20347 | GRM1 | 2911 | 210940_s_at | 0.0127 | 0.8631 | |
| GSE23400 | GRM1 | 2911 | 210939_s_at | -0.1105 | 0.0033 | |
| GSE26886 | GRM1 | 2911 | 210940_s_at | 0.1854 | 0.1619 | |
| GSE29001 | GRM1 | 2911 | 207299_s_at | -0.1057 | 0.4606 | |
| GSE38129 | GRM1 | 2911 | 210940_s_at | 0.0436 | 0.5376 | |
| GSE45670 | GRM1 | 2911 | 210940_s_at | 0.0201 | 0.8280 | |
| GSE53622 | GRM1 | 2911 | 88572 | 0.0114 | 0.9285 | |
| GSE53624 | GRM1 | 2911 | 88572 | -0.1332 | 0.1651 | |
| GSE63941 | GRM1 | 2911 | 210940_s_at | 0.0777 | 0.5884 | |
| GSE77861 | GRM1 | 2911 | 210940_s_at | -0.0219 | 0.8654 | |
| GSE97050 | GRM1 | 2911 | A_33_P3271965 | -0.3342 | 0.2491 | |
| TCGA | GRM1 | 2911 | RNAseq | 1.5637 | 0.0282 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GRM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRM1 | 2911 | 2 | 4 | 24 | |
| GSE20123 | GRM1 | 2911 | 2 | 3 | 25 | |
| GSE43470 | GRM1 | 2911 | 5 | 0 | 38 | |
| GSE46452 | GRM1 | 2911 | 3 | 11 | 45 | |
| GSE47630 | GRM1 | 2911 | 9 | 4 | 27 | |
| GSE54993 | GRM1 | 2911 | 3 | 2 | 65 | |
| GSE54994 | GRM1 | 2911 | 8 | 8 | 37 | |
| GSE60625 | GRM1 | 2911 | 0 | 1 | 10 | |
| GSE74703 | GRM1 | 2911 | 4 | 0 | 32 | |
| GSE74704 | GRM1 | 2911 | 0 | 1 | 19 | |
| TCGA | GRM1 | 2911 | 13 | 20 | 63 |
Total number of gains: 49; Total number of losses: 54; Total Number of normals: 385.
Somatic mutations of GRM1:
Generating mutation plots.
Highly correlated genes for GRM1:
Showing top 20/942 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRM1 | KRTAP10-12 | 0.800042 | 3 | 0 | 3 |
| GRM1 | OR4C3 | 0.791813 | 3 | 0 | 3 |
| GRM1 | STRC | 0.78515 | 3 | 0 | 3 |
| GRM1 | YY2 | 0.779997 | 3 | 0 | 3 |
| GRM1 | PRSS38 | 0.776869 | 3 | 0 | 3 |
| GRM1 | KRTAP6-1 | 0.776764 | 3 | 0 | 3 |
| GRM1 | PLA2G2C | 0.774937 | 3 | 0 | 3 |
| GRM1 | OR2B11 | 0.772763 | 3 | 0 | 3 |
| GRM1 | SLC22A25 | 0.76385 | 4 | 0 | 4 |
| GRM1 | CIB3 | 0.755373 | 3 | 0 | 3 |
| GRM1 | OR10AD1 | 0.751574 | 3 | 0 | 3 |
| GRM1 | DEFB108B | 0.748622 | 3 | 0 | 3 |
| GRM1 | LBX2 | 0.746163 | 3 | 0 | 3 |
| GRM1 | LINC00620 | 0.740087 | 3 | 0 | 3 |
| GRM1 | PIP5KL1 | 0.730326 | 3 | 0 | 3 |
| GRM1 | FBRSL1 | 0.728387 | 3 | 0 | 3 |
| GRM1 | ZNF527 | 0.728377 | 3 | 0 | 3 |
| GRM1 | PROCA1 | 0.727989 | 4 | 0 | 4 |
| GRM1 | OR2T27 | 0.726107 | 3 | 0 | 3 |
| GRM1 | C9orf153 | 0.718849 | 3 | 0 | 3 |
For details and further investigation, click here
