| Full name: potassium channel tetramerization domain containing 11 | Alias Symbol: REN|KCASH1 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 147040 | HGNC ID: HGNC:21302 | Ensembl Gene: ENSG00000213859 | OMIM ID: 609848 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KCTD11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCTD11 | 147040 | 235857_at | -0.9841 | 0.5152 | |
| GSE26886 | KCTD11 | 147040 | 235857_at | -1.0482 | 0.0063 | |
| GSE45670 | KCTD11 | 147040 | 235857_at | -0.1338 | 0.7501 | |
| GSE53622 | KCTD11 | 147040 | 24281 | -0.5047 | 0.0018 | |
| GSE53624 | KCTD11 | 147040 | 24281 | -0.9013 | 0.0000 | |
| GSE63941 | KCTD11 | 147040 | 235857_at | -0.5234 | 0.4049 | |
| GSE77861 | KCTD11 | 147040 | 235857_at | 0.0597 | 0.9209 | |
| GSE97050 | KCTD11 | 147040 | A_23_P354027 | 0.0057 | 0.9852 | |
| SRP007169 | KCTD11 | 147040 | RNAseq | -2.0314 | 0.0000 | |
| SRP008496 | KCTD11 | 147040 | RNAseq | -1.5526 | 0.0000 | |
| SRP064894 | KCTD11 | 147040 | RNAseq | -1.2327 | 0.0007 | |
| SRP133303 | KCTD11 | 147040 | RNAseq | -0.4288 | 0.1905 | |
| SRP159526 | KCTD11 | 147040 | RNAseq | -1.6560 | 0.0011 | |
| SRP193095 | KCTD11 | 147040 | RNAseq | -0.0458 | 0.8574 | |
| SRP219564 | KCTD11 | 147040 | RNAseq | -1.3260 | 0.0432 | |
| TCGA | KCTD11 | 147040 | RNAseq | 0.1408 | 0.1740 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by KCTD11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCTD11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCTD11 | 147040 | 4 | 2 | 24 | |
| GSE20123 | KCTD11 | 147040 | 4 | 3 | 23 | |
| GSE43470 | KCTD11 | 147040 | 1 | 4 | 38 | |
| GSE46452 | KCTD11 | 147040 | 34 | 1 | 24 | |
| GSE47630 | KCTD11 | 147040 | 7 | 1 | 32 | |
| GSE54993 | KCTD11 | 147040 | 4 | 3 | 63 | |
| GSE54994 | KCTD11 | 147040 | 5 | 8 | 40 | |
| GSE60625 | KCTD11 | 147040 | 4 | 0 | 7 | |
| GSE74703 | KCTD11 | 147040 | 1 | 2 | 33 | |
| GSE74704 | KCTD11 | 147040 | 2 | 1 | 17 | |
| TCGA | KCTD11 | 147040 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of KCTD11:
Generating mutation plots.
Highly correlated genes for KCTD11:
Showing top 20/595 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCTD11 | NUAK2 | 0.787763 | 3 | 0 | 3 |
| KCTD11 | NPAS2 | 0.720755 | 3 | 0 | 3 |
| KCTD11 | DAPP1 | 0.716267 | 5 | 0 | 5 |
| KCTD11 | SLC50A1 | 0.706399 | 3 | 0 | 3 |
| KCTD11 | ADCY7 | 0.699652 | 3 | 0 | 3 |
| KCTD11 | PGM2 | 0.69219 | 5 | 0 | 4 |
| KCTD11 | EPGN | 0.688156 | 3 | 0 | 3 |
| KCTD11 | DNASE1L3 | 0.688096 | 4 | 0 | 3 |
| KCTD11 | OSBPL10 | 0.684182 | 5 | 0 | 5 |
| KCTD11 | ELOVL1 | 0.679467 | 3 | 0 | 3 |
| KCTD11 | SLC46A2 | 0.676267 | 5 | 0 | 5 |
| KCTD11 | EIF4E2 | 0.676068 | 4 | 0 | 4 |
| KCTD11 | BCL10 | 0.67081 | 6 | 0 | 5 |
| KCTD11 | TREX2 | 0.670561 | 3 | 0 | 3 |
| KCTD11 | OSTF1 | 0.670174 | 5 | 0 | 5 |
| KCTD11 | ULBP2 | 0.667993 | 3 | 0 | 3 |
| KCTD11 | MIR210HG | 0.667936 | 7 | 0 | 6 |
| KCTD11 | ATG9B | 0.665616 | 5 | 0 | 5 |
| KCTD11 | LYNX1 | 0.661925 | 4 | 0 | 4 |
| KCTD11 | PXMP2 | 0.661551 | 3 | 0 | 3 |
For details and further investigation, click here
