| Full name: adenosine A1 receptor | Alias Symbol: RDC7 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 134 | HGNC ID: HGNC:262 | Ensembl Gene: ENSG00000163485 | OMIM ID: 102775 |
| Drug and gene relationship at DGIdb | |||
ADORA1 involved pathways:
Expression of ADORA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADORA1 | 134 | 216220_s_at | -0.1287 | 0.5655 | |
| GSE20347 | ADORA1 | 134 | 216220_s_at | -0.0217 | 0.8434 | |
| GSE23400 | ADORA1 | 134 | 216220_s_at | -0.0379 | 0.3065 | |
| GSE26886 | ADORA1 | 134 | 216220_s_at | 0.0296 | 0.8283 | |
| GSE29001 | ADORA1 | 134 | 216220_s_at | -0.0343 | 0.8663 | |
| GSE38129 | ADORA1 | 134 | 216220_s_at | -0.1256 | 0.0730 | |
| GSE45670 | ADORA1 | 134 | 216220_s_at | 0.0122 | 0.8958 | |
| GSE53622 | ADORA1 | 134 | 47633 | -1.1323 | 0.0000 | |
| GSE53624 | ADORA1 | 134 | 47633 | -0.3929 | 0.0000 | |
| GSE63941 | ADORA1 | 134 | 216220_s_at | -0.2988 | 0.0717 | |
| GSE77861 | ADORA1 | 134 | 216220_s_at | -0.0955 | 0.5072 | |
| GSE97050 | ADORA1 | 134 | A_23_P74299 | -0.0550 | 0.7788 | |
| SRP133303 | ADORA1 | 134 | RNAseq | 0.7192 | 0.0339 | |
| SRP159526 | ADORA1 | 134 | RNAseq | 1.9592 | 0.0216 | |
| SRP219564 | ADORA1 | 134 | RNAseq | 2.1213 | 0.0000 | |
| TCGA | ADORA1 | 134 | RNAseq | 0.3862 | 0.1538 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by ADORA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADORA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADORA1 | 134 | 11 | 0 | 19 | |
| GSE20123 | ADORA1 | 134 | 11 | 0 | 19 | |
| GSE43470 | ADORA1 | 134 | 6 | 0 | 37 | |
| GSE46452 | ADORA1 | 134 | 3 | 1 | 55 | |
| GSE47630 | ADORA1 | 134 | 14 | 0 | 26 | |
| GSE54993 | ADORA1 | 134 | 0 | 6 | 64 | |
| GSE54994 | ADORA1 | 134 | 15 | 0 | 38 | |
| GSE60625 | ADORA1 | 134 | 0 | 0 | 11 | |
| GSE74703 | ADORA1 | 134 | 6 | 0 | 30 | |
| GSE74704 | ADORA1 | 134 | 5 | 0 | 15 | |
| TCGA | ADORA1 | 134 | 44 | 4 | 48 |
Total number of gains: 115; Total number of losses: 11; Total Number of normals: 362.
Somatic mutations of ADORA1:
Generating mutation plots.
Highly correlated genes for ADORA1:
Showing top 20/395 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADORA1 | OR10G8 | 0.807499 | 3 | 0 | 3 |
| ADORA1 | SLC22A31 | 0.741231 | 4 | 0 | 4 |
| ADORA1 | LRTM1 | 0.738223 | 3 | 0 | 3 |
| ADORA1 | THRSP | 0.737581 | 3 | 0 | 3 |
| ADORA1 | TNF | 0.732489 | 3 | 0 | 3 |
| ADORA1 | CCDC42 | 0.713455 | 3 | 0 | 3 |
| ADORA1 | DCDC2B | 0.709428 | 3 | 0 | 3 |
| ADORA1 | GRM6 | 0.709155 | 4 | 0 | 3 |
| ADORA1 | C9orf131 | 0.703984 | 4 | 0 | 4 |
| ADORA1 | MGAT5B | 0.70206 | 3 | 0 | 3 |
| ADORA1 | CTSG | 0.701423 | 3 | 0 | 3 |
| ADORA1 | C16orf82 | 0.700168 | 3 | 0 | 3 |
| ADORA1 | FAM171A2 | 0.69924 | 4 | 0 | 4 |
| ADORA1 | SHANK1 | 0.694782 | 6 | 0 | 6 |
| ADORA1 | POU3F3 | 0.693252 | 3 | 0 | 3 |
| ADORA1 | NPEPL1 | 0.687039 | 6 | 0 | 6 |
| ADORA1 | GALNT9 | 0.68397 | 6 | 0 | 5 |
| ADORA1 | ADCY1 | 0.683672 | 3 | 0 | 3 |
| ADORA1 | PSPN | 0.682946 | 5 | 0 | 4 |
| ADORA1 | BTBD19 | 0.682124 | 5 | 0 | 3 |
For details and further investigation, click here
