| Full name: glutamate metabotropic receptor 6 | Alias Symbol: GPRC1F|mGlu6|MGLUR6|CSNB1B | ||
| Type: protein-coding gene | Cytoband: 5q35.3 | ||
| Entrez ID: 2916 | HGNC ID: HGNC:4598 | Ensembl Gene: ENSG00000113262 | OMIM ID: 604096 |
| Drug and gene relationship at DGIdb | |||
GRM6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04724 | Glutamatergic synapse |
Expression of GRM6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GRM6 | 2916 | 208035_at | -0.1761 | 0.4618 | |
| GSE20347 | GRM6 | 2916 | 208035_at | -0.0927 | 0.2920 | |
| GSE23400 | GRM6 | 2916 | 208035_at | -0.1331 | 0.0086 | |
| GSE26886 | GRM6 | 2916 | 208035_at | -0.3967 | 0.0006 | |
| GSE29001 | GRM6 | 2916 | 208035_at | -0.1787 | 0.3584 | |
| GSE38129 | GRM6 | 2916 | 208035_at | -0.0967 | 0.2515 | |
| GSE45670 | GRM6 | 2916 | 208035_at | 0.0746 | 0.4584 | |
| GSE53622 | GRM6 | 2916 | 8363 | -0.2795 | 0.0009 | |
| GSE53624 | GRM6 | 2916 | 8363 | -0.2466 | 0.0049 | |
| GSE63941 | GRM6 | 2916 | 208035_at | -0.0798 | 0.6356 | |
| GSE77861 | GRM6 | 2916 | 208035_at | -0.0906 | 0.2783 | |
| GSE97050 | GRM6 | 2916 | A_33_P3420386 | -0.2519 | 0.3370 | |
| SRP064894 | GRM6 | 2916 | RNAseq | 0.0879 | 0.7273 | |
| SRP133303 | GRM6 | 2916 | RNAseq | -0.0871 | 0.5025 | |
| SRP159526 | GRM6 | 2916 | RNAseq | 0.3044 | 0.5553 | |
| SRP193095 | GRM6 | 2916 | RNAseq | 0.0331 | 0.8334 | |
| SRP219564 | GRM6 | 2916 | RNAseq | 0.2011 | 0.5405 | |
| TCGA | GRM6 | 2916 | RNAseq | -1.2347 | 0.0100 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GRM6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GRM6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GRM6 | 2916 | 2 | 13 | 15 | |
| GSE20123 | GRM6 | 2916 | 2 | 13 | 15 | |
| GSE43470 | GRM6 | 2916 | 1 | 11 | 31 | |
| GSE46452 | GRM6 | 2916 | 0 | 27 | 32 | |
| GSE47630 | GRM6 | 2916 | 1 | 20 | 19 | |
| GSE54993 | GRM6 | 2916 | 10 | 2 | 58 | |
| GSE54994 | GRM6 | 2916 | 2 | 17 | 34 | |
| GSE60625 | GRM6 | 2916 | 1 | 0 | 10 | |
| GSE74703 | GRM6 | 2916 | 1 | 7 | 28 | |
| GSE74704 | GRM6 | 2916 | 1 | 6 | 13 | |
| TCGA | GRM6 | 2916 | 9 | 35 | 52 |
Total number of gains: 30; Total number of losses: 151; Total Number of normals: 307.
Somatic mutations of GRM6:
Generating mutation plots.
Highly correlated genes for GRM6:
Showing top 20/570 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GRM6 | NOL4 | 0.753807 | 3 | 0 | 3 |
| GRM6 | G6PC2 | 0.738373 | 6 | 0 | 6 |
| GRM6 | GPD1 | 0.717825 | 4 | 0 | 4 |
| GRM6 | PSG6 | 0.713926 | 6 | 0 | 6 |
| GRM6 | PRODH2 | 0.713128 | 5 | 0 | 5 |
| GRM6 | CLEC4D | 0.710808 | 3 | 0 | 3 |
| GRM6 | ADORA1 | 0.709155 | 4 | 0 | 3 |
| GRM6 | ABCC6 | 0.707303 | 3 | 0 | 3 |
| GRM6 | SLC5A4 | 0.701562 | 6 | 0 | 5 |
| GRM6 | ADM2 | 0.700757 | 5 | 0 | 5 |
| GRM6 | RNF32 | 0.697914 | 3 | 0 | 3 |
| GRM6 | CYP2D6 | 0.695829 | 6 | 0 | 6 |
| GRM6 | ADAMTS13 | 0.695527 | 6 | 0 | 6 |
| GRM6 | OR10H3 | 0.695261 | 7 | 0 | 7 |
| GRM6 | CETN1 | 0.694498 | 4 | 0 | 4 |
| GRM6 | IFNA17 | 0.692742 | 5 | 0 | 5 |
| GRM6 | COL4A3 | 0.689502 | 4 | 0 | 4 |
| GRM6 | SCGN | 0.684253 | 4 | 0 | 3 |
| GRM6 | IL9 | 0.68399 | 4 | 0 | 3 |
| GRM6 | PRAMEF12 | 0.680546 | 7 | 0 | 6 |
For details and further investigation, click here
