POU3F3

 

Full name: POU class 3 homeobox 3 Alias Symbol: BRN1|OTF8
Type: protein-coding gene Cytoband: 2q12.1
Entrez ID: 5455 HGNC ID: HGNC:9216 Ensembl Gene: ENSG00000198914 OMIM ID: 602480
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of POU3F3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POU3F3 5455 208563_x_at 0.0430 0.8953
GSE20347 POU3F3 5455 208563_x_at -0.0327 0.6962
GSE23400 POU3F3 5455 208563_x_at -0.0748 0.0182
GSE26886 POU3F3 5455 208563_x_at 0.1685 0.1514
GSE29001 POU3F3 5455 208563_x_at -0.0035 0.9773
GSE38129 POU3F3 5455 208563_x_at -0.0712 0.2363
GSE45670 POU3F3 5455 237008_at 0.1129 0.2374
GSE53622 POU3F3 5455 80245 -0.4230 0.0000
GSE53624 POU3F3 5455 80245 -0.1881 0.0000
GSE63941 POU3F3 5455 237008_at 0.0977 0.5975
GSE77861 POU3F3 5455 237008_at -0.0980 0.2831
GSE97050 POU3F3 5455 A_33_P3231908 -0.1236 0.6455
TCGA POU3F3 5455 RNAseq -1.9421 0.0841

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by POU3F3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POU3F3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POU3F3 5455 3 2 25
GSE20123 POU3F3 5455 3 2 25
GSE43470 POU3F3 5455 3 1 39
GSE46452 POU3F3 5455 1 4 54
GSE47630 POU3F3 5455 7 0 33
GSE54993 POU3F3 5455 0 6 64
GSE54994 POU3F3 5455 10 0 43
GSE60625 POU3F3 5455 0 3 8
GSE74703 POU3F3 5455 3 1 32
GSE74704 POU3F3 5455 2 2 16
TCGA POU3F3 5455 35 5 56

Total number of gains: 67; Total number of losses: 26; Total Number of normals: 395.  

 

Somatic mutations of POU3F3:

 

Generating mutation plots.

 

Highly correlated genes for POU3F3:

 

Showing top 20/184 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POU3F3GARNL30.747365303
POU3F3SCARF20.723215404
POU3F3BTNL90.711141303
POU3F3ADCY10.708633303
POU3F3FGF170.699724404
POU3F3CABP10.696107303
POU3F3ADORA10.693252303
POU3F3C14orf1800.687753303
POU3F3LTB4R20.686255303
POU3F3ZAN0.680881303
POU3F3GPR390.673676303
POU3F3BRSK10.673221303
POU3F3LINC005630.662543403
POU3F3SPEF10.658718403
POU3F3GDNF0.655786303
POU3F3FAM186B0.651425303
POU3F3IL17B0.649018404
POU3F3CAPN130.644219303
POU3F3VGF0.641174403
POU3F3HK30.641117303

For details and further investigation, click here