TNF

 

Full name: tumor necrosis factor Alias Symbol: TNFSF2|DIF|TNF-alpha
Type: protein-coding gene Cytoband: 6p21.33
Entrez ID: 7124 HGNC ID: HGNC:11892 Ensembl Gene: ENSG00000232810 OMIM ID: 191160
Drug and gene relationship at DGIdb

 

TNF involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04150mTOR signaling pathway
hsa04210Apoptosis
hsa04350TGF-beta signaling pathway
hsa04380Osteoclast differentiation
hsa04612Antigen processing and presentation
hsa04620Toll-like receptor signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04668TNF signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05134Legionellosis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05168Herpes simplex infection
hsa05205Proteoglycans in cancer
hsa05321Inflammatory bowel disease (IBD)

 

Expression of TNF:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TNF 7124 207113_s_at 0.3269 0.7120
GSE20347 TNF 7124 207113_s_at 0.0764 0.3876
GSE23400 TNF 7124 207113_s_at -0.0925 0.0132
GSE26886 TNF 7124 207113_s_at -0.1220 0.5223
GSE29001 TNF 7124 207113_s_at -0.1858 0.3248
GSE38129 TNF 7124 207113_s_at 0.0001 0.9991
GSE45670 TNF 7124 207113_s_at 0.3442 0.1651
GSE53622 TNF 7124 74417 0.1258 0.5076
GSE53624 TNF 7124 74417 0.0269 0.8456
GSE63941 TNF 7124 207113_s_at 0.1747 0.1971
GSE77861 TNF 7124 207113_s_at -0.1296 0.1583
GSE97050 TNF 7124 A_23_P376488 -0.7488 0.1625
SRP064894 TNF 7124 RNAseq -0.1714 0.6668
SRP133303 TNF 7124 RNAseq -0.6460 0.0992
SRP159526 TNF 7124 RNAseq 0.7312 0.4178
SRP193095 TNF 7124 RNAseq -0.1171 0.7273
SRP219564 TNF 7124 RNAseq -0.2124 0.6904
TCGA TNF 7124 RNAseq 1.7666 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by TNF expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TNF:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TNF 7124 5 1 24
GSE20123 TNF 7124 5 1 24
GSE43470 TNF 7124 6 3 34
GSE46452 TNF 7124 1 10 48
GSE47630 TNF 7124 7 5 28
GSE54993 TNF 7124 2 1 67
GSE54994 TNF 7124 11 4 38
GSE60625 TNF 7124 0 1 10
GSE74703 TNF 7124 6 1 29
GSE74704 TNF 7124 2 0 18
TCGA TNF 7124 16 16 64

Total number of gains: 61; Total number of losses: 43; Total Number of normals: 384.  

 

Somatic mutations of TNF:

 

Generating mutation plots.

 

Highly correlated genes for TNF:

 

Showing top 20/151 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TNFADORA10.732489303
TNFCRABP10.729644303
TNFPRLH0.726591303
TNFPAX30.712198303
TNFKISS10.687558303
TNFPRODH20.687249303
TNFRASL10A0.685477303
TNFACR0.679822303
TNFPNPLA50.679356303
TNFFSCN30.675748404
TNFIL210.674464403
TNFFAM189A10.670613303
TNFKLHL350.669984303
TNFSLC22A110.663607403
TNFCDHR50.662397303
TNFB3GALT10.662201403
TNFLCT0.658731303
TNFAQP60.657775403
TNFMAGEA80.649647403
TNFCYP4A110.648007303

For details and further investigation, click here