ADCY1

 

Full name: adenylate cyclase 1 Alias Symbol: AC1
Type: protein-coding gene Cytoband: 7p12.3
Entrez ID: 107 HGNC ID: HGNC:232 Ensembl Gene: ENSG00000164742 OMIM ID: 103072
Drug and gene relationship at DGIdb

 

ADCY1 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04114Oocyte meiosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04925Aldosterone synthesis and secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05032Morphine addiction
hsa05142Chagas disease (American trypanosomiasis)
hsa05166HTLV-I infection

 

Expression of ADCY1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADCY1 107 232062_at -0.2012 0.3849
GSE20347 ADCY1 107 215348_at -0.0928 0.2054
GSE23400 ADCY1 107 215340_at -0.1147 0.0072
GSE26886 ADCY1 107 232062_at -0.0528 0.7478
GSE29001 ADCY1 107 213245_at 0.5366 0.0798
GSE38129 ADCY1 107 213245_at 0.0986 0.6778
GSE45670 ADCY1 107 232062_at 0.2867 0.0016
GSE63941 ADCY1 107 213245_at 0.4918 0.7221
GSE77861 ADCY1 107 215348_at 0.0594 0.7833
GSE97050 ADCY1 107 A_24_P577694 -0.0544 0.9037
SRP064894 ADCY1 107 RNAseq 1.6016 0.0003
SRP133303 ADCY1 107 RNAseq 0.7778 0.0413
SRP159526 ADCY1 107 RNAseq 0.8153 0.2018
SRP193095 ADCY1 107 RNAseq 1.7694 0.0000
SRP219564 ADCY1 107 RNAseq 2.2770 0.0028
TCGA ADCY1 107 RNAseq -0.6093 0.0020

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by ADCY1 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of ADCY1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADCY1 107 15 0 15
GSE20123 ADCY1 107 13 0 17
GSE43470 ADCY1 107 4 0 39
GSE46452 ADCY1 107 11 1 47
GSE47630 ADCY1 107 8 1 31
GSE54993 ADCY1 107 0 8 62
GSE54994 ADCY1 107 16 3 34
GSE60625 ADCY1 107 0 0 11
GSE74703 ADCY1 107 4 0 32
GSE74704 ADCY1 107 7 0 13
TCGA ADCY1 107 50 7 39

Total number of gains: 128; Total number of losses: 20; Total Number of normals: 340.  

 

Somatic mutations of ADCY1:

 

Generating mutation plots.

 

Highly correlated genes for ADCY1:

 

Showing top 20/383 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADCY1CDH230.75661303
ADCY1TMUB10.753887303
ADCY1ASB100.751919303
ADCY1CLSTN30.75096303
ADCY1ABCC60.729097303
ADCY1MAPK8IP20.721319303
ADCY1SHC20.715395303
ADCY1ESRRB0.71499303
ADCY1CDH40.712808303
ADCY1SCGN0.710526404
ADCY1POU3F30.708633303
ADCY1ITGA2B0.708497303
ADCY1AGPAT10.708429303
ADCY1NOX10.70796404
ADCY1ATOH80.705514303
ADCY1GPR260.703796303
ADCY1ACADS0.70374303
ADCY1MPP20.702724404
ADCY1ATAD3C0.701225303
ADCY1DNAH60.693789404

For details and further investigation, click here