| Full name: adrenoceptor alpha 2C | Alias Symbol: ADRARL2 | ||
| Type: protein-coding gene | Cytoband: 4p16.3 | ||
| Entrez ID: 152 | HGNC ID: HGNC:283 | Ensembl Gene: ENSG00000184160 | OMIM ID: 104250 |
| Drug and gene relationship at DGIdb | |||
ADRA2C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway |
Expression of ADRA2C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADRA2C | 152 | 206128_at | 0.1599 | 0.5745 | |
| GSE20347 | ADRA2C | 152 | 206128_at | 0.1887 | 0.1030 | |
| GSE23400 | ADRA2C | 152 | 206128_at | -0.0578 | 0.0909 | |
| GSE26886 | ADRA2C | 152 | 206128_at | 0.6575 | 0.0000 | |
| GSE29001 | ADRA2C | 152 | 206128_at | 0.0930 | 0.7200 | |
| GSE38129 | ADRA2C | 152 | 206128_at | 0.1310 | 0.2534 | |
| GSE45670 | ADRA2C | 152 | 206128_at | 0.0289 | 0.8519 | |
| GSE53622 | ADRA2C | 152 | 66572 | 0.4127 | 0.0000 | |
| GSE53624 | ADRA2C | 152 | 66572 | 0.4183 | 0.0000 | |
| GSE63941 | ADRA2C | 152 | 206128_at | 0.5407 | 0.1608 | |
| GSE77861 | ADRA2C | 152 | 206128_at | -0.0283 | 0.8975 | |
| GSE97050 | ADRA2C | 152 | A_23_P256158 | 0.0385 | 0.8535 | |
| SRP133303 | ADRA2C | 152 | RNAseq | 1.2194 | 0.0061 | |
| SRP159526 | ADRA2C | 152 | RNAseq | 0.4410 | 0.4914 | |
| SRP219564 | ADRA2C | 152 | RNAseq | 0.3725 | 0.5729 | |
| TCGA | ADRA2C | 152 | RNAseq | 0.1066 | 0.6844 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ADRA2C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADRA2C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADRA2C | 152 | 0 | 17 | 13 | |
| GSE20123 | ADRA2C | 152 | 0 | 17 | 13 | |
| GSE43470 | ADRA2C | 152 | 0 | 18 | 25 | |
| GSE46452 | ADRA2C | 152 | 1 | 36 | 22 | |
| GSE47630 | ADRA2C | 152 | 1 | 19 | 20 | |
| GSE54993 | ADRA2C | 152 | 10 | 0 | 60 | |
| GSE54994 | ADRA2C | 152 | 3 | 12 | 38 | |
| GSE60625 | ADRA2C | 152 | 0 | 0 | 11 | |
| GSE74703 | ADRA2C | 152 | 0 | 14 | 22 | |
| GSE74704 | ADRA2C | 152 | 0 | 9 | 11 | |
| TCGA | ADRA2C | 152 | 7 | 47 | 42 |
Total number of gains: 22; Total number of losses: 189; Total Number of normals: 277.
Somatic mutations of ADRA2C:
Generating mutation plots.
Highly correlated genes for ADRA2C:
Showing top 20/538 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADRA2C | ZNF524 | 0.809514 | 3 | 0 | 3 |
| ADRA2C | STK32C | 0.760106 | 3 | 0 | 3 |
| ADRA2C | WNT9A | 0.756995 | 3 | 0 | 3 |
| ADRA2C | ESPNL | 0.751765 | 3 | 0 | 3 |
| ADRA2C | CPAMD8 | 0.747825 | 3 | 0 | 3 |
| ADRA2C | RPP25 | 0.746261 | 3 | 0 | 3 |
| ADRA2C | ATP8B3 | 0.73948 | 3 | 0 | 3 |
| ADRA2C | ABCB9 | 0.737848 | 3 | 0 | 3 |
| ADRA2C | SLC34A1 | 0.734261 | 3 | 0 | 3 |
| ADRA2C | PHF21A | 0.731869 | 4 | 0 | 3 |
| ADRA2C | SCARF2 | 0.723302 | 3 | 0 | 3 |
| ADRA2C | C19orf53 | 0.72211 | 3 | 0 | 3 |
| ADRA2C | SYCE3 | 0.72128 | 4 | 0 | 3 |
| ADRA2C | NKAIN4 | 0.719587 | 4 | 0 | 3 |
| ADRA2C | SNAI2 | 0.719395 | 3 | 0 | 3 |
| ADRA2C | IGSF9B | 0.712788 | 3 | 0 | 3 |
| ADRA2C | JAKMIP1 | 0.712273 | 3 | 0 | 3 |
| ADRA2C | MYLK3 | 0.711699 | 3 | 0 | 3 |
| ADRA2C | CNOT3 | 0.707965 | 3 | 0 | 3 |
| ADRA2C | FBRSL1 | 0.706987 | 3 | 0 | 3 |
For details and further investigation, click here
