| Full name: myosin light chain kinase 3 | Alias Symbol: caMLCK|MLCK | ||
| Type: protein-coding gene | Cytoband: 16q11.2 | ||
| Entrez ID: 91807 | HGNC ID: HGNC:29826 | Ensembl Gene: ENSG00000140795 | OMIM ID: 612147 |
| Drug and gene relationship at DGIdb | |||
MYLK3 involved pathways:
Expression of MYLK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MYLK3 | 91807 | 1562411_at | 0.0791 | 0.7695 | |
| GSE20347 | MYLK3 | 91807 | 217623_at | 0.0057 | 0.9155 | |
| GSE23400 | MYLK3 | 91807 | 217623_at | 0.0033 | 0.8414 | |
| GSE26886 | MYLK3 | 91807 | 1562411_at | -0.1291 | 0.2517 | |
| GSE29001 | MYLK3 | 91807 | 217623_at | 0.1095 | 0.2463 | |
| GSE38129 | MYLK3 | 91807 | 217623_at | 0.0066 | 0.8896 | |
| GSE45670 | MYLK3 | 91807 | 1562411_at | -0.1219 | 0.2061 | |
| GSE63941 | MYLK3 | 91807 | 1562411_at | -0.0602 | 0.7057 | |
| GSE77861 | MYLK3 | 91807 | 1562411_at | -0.0423 | 0.6427 | |
| GSE97050 | MYLK3 | 91807 | A_33_P3300217 | -0.0020 | 0.9934 | |
| SRP007169 | MYLK3 | 91807 | RNAseq | -0.0476 | 0.9336 | |
| SRP064894 | MYLK3 | 91807 | RNAseq | -0.1419 | 0.5284 | |
| SRP133303 | MYLK3 | 91807 | RNAseq | 0.0509 | 0.7041 | |
| SRP159526 | MYLK3 | 91807 | RNAseq | 0.2664 | 0.4333 | |
| SRP193095 | MYLK3 | 91807 | RNAseq | 0.0872 | 0.5683 | |
| SRP219564 | MYLK3 | 91807 | RNAseq | -0.2110 | 0.6216 | |
| TCGA | MYLK3 | 91807 | RNAseq | -1.4656 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MYLK3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MYLK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MYLK3 | 91807 | 2 | 1 | 27 | |
| GSE20123 | MYLK3 | 91807 | 2 | 1 | 27 | |
| GSE43470 | MYLK3 | 91807 | 2 | 7 | 34 | |
| GSE46452 | MYLK3 | 91807 | 38 | 1 | 20 | |
| GSE47630 | MYLK3 | 91807 | 11 | 7 | 22 | |
| GSE54993 | MYLK3 | 91807 | 2 | 5 | 63 | |
| GSE54994 | MYLK3 | 91807 | 6 | 10 | 37 | |
| GSE60625 | MYLK3 | 91807 | 4 | 0 | 7 | |
| GSE74703 | MYLK3 | 91807 | 2 | 4 | 30 | |
| GSE74704 | MYLK3 | 91807 | 2 | 1 | 17 | |
| TCGA | MYLK3 | 91807 | 29 | 11 | 56 |
Total number of gains: 100; Total number of losses: 48; Total Number of normals: 340.
Somatic mutations of MYLK3:
Generating mutation plots.
Highly correlated genes for MYLK3:
Showing top 20/42 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MYLK3 | C8G | 0.788989 | 3 | 0 | 3 |
| MYLK3 | GAST | 0.75434 | 3 | 0 | 3 |
| MYLK3 | DPEP3 | 0.737587 | 3 | 0 | 3 |
| MYLK3 | C4BPA | 0.724605 | 3 | 0 | 3 |
| MYLK3 | HOXA11 | 0.722651 | 3 | 0 | 3 |
| MYLK3 | MAGEE1 | 0.715601 | 3 | 0 | 3 |
| MYLK3 | FSCN2 | 0.714227 | 3 | 0 | 3 |
| MYLK3 | ADRA2C | 0.711699 | 3 | 0 | 3 |
| MYLK3 | ANKRD33B | 0.705784 | 3 | 0 | 3 |
| MYLK3 | B3GALT1 | 0.70192 | 3 | 0 | 3 |
| MYLK3 | LINC00302 | 0.699287 | 4 | 0 | 3 |
| MYLK3 | AANAT | 0.695844 | 3 | 0 | 3 |
| MYLK3 | TNR | 0.689799 | 3 | 0 | 3 |
| MYLK3 | NOS3 | 0.677374 | 3 | 0 | 3 |
| MYLK3 | MOGAT3 | 0.673815 | 3 | 0 | 3 |
| MYLK3 | SORCS3 | 0.660463 | 3 | 0 | 3 |
| MYLK3 | GYPE | 0.6593 | 4 | 0 | 3 |
| MYLK3 | GPBAR1 | 0.657716 | 3 | 0 | 3 |
| MYLK3 | MC3R | 0.646098 | 3 | 0 | 3 |
| MYLK3 | BAHCC1 | 0.641432 | 4 | 0 | 4 |
For details and further investigation, click here
