SNAI2

 

Full name: snail family transcriptional repressor 2 Alias Symbol: SLUGH1|SNAIL2|SLUGH
Type: protein-coding gene Cytoband: 8q11.21
Entrez ID: 6591 HGNC ID: HGNC:11094 Ensembl Gene: ENSG00000019549 OMIM ID: 602150
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

SNAI2 involved pathways:

KEGG pathway Description View
hsa04390Hippo signaling pathway
hsa04520Adherens junction

 

Expression of SNAI2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SNAI2 6591 213139_at 0.9780 0.1616
GSE20347 SNAI2 6591 213139_at 2.0284 0.0000
GSE23400 SNAI2 6591 213139_at 2.4488 0.0000
GSE26886 SNAI2 6591 213139_at 1.1692 0.0000
GSE29001 SNAI2 6591 213139_at 2.2494 0.0000
GSE38129 SNAI2 6591 213139_at 1.9961 0.0000
GSE45670 SNAI2 6591 213139_at 0.9719 0.0045
GSE63941 SNAI2 6591 213139_at -1.9116 0.1144
GSE77861 SNAI2 6591 213139_at 1.3560 0.0146
GSE97050 SNAI2 6591 A_23_P169039 0.1160 0.6765
SRP007169 SNAI2 6591 RNAseq 2.3647 0.0000
SRP008496 SNAI2 6591 RNAseq 2.3637 0.0000
SRP064894 SNAI2 6591 RNAseq 2.0978 0.0000
SRP133303 SNAI2 6591 RNAseq 1.8152 0.0000
SRP159526 SNAI2 6591 RNAseq 1.1205 0.0001
SRP193095 SNAI2 6591 RNAseq 1.5586 0.0000
SRP219564 SNAI2 6591 RNAseq 1.7427 0.0007
TCGA SNAI2 6591 RNAseq 0.7598 0.0000

Upregulated datasets: 13; Downregulated datasets: 0.  

 

Survival by SNAI2 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of SNAI2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SNAI2 6591 15 2 13
GSE20123 SNAI2 6591 15 2 13
GSE43470 SNAI2 6591 13 3 27
GSE46452 SNAI2 6591 21 3 35
GSE47630 SNAI2 6591 21 2 17
GSE54993 SNAI2 6591 1 16 53
GSE54994 SNAI2 6591 28 0 25
GSE60625 SNAI2 6591 0 5 6
GSE74703 SNAI2 6591 12 2 22
GSE74704 SNAI2 6591 11 0 9
TCGA SNAI2 6591 46 8 42

Total number of gains: 183; Total number of losses: 43; Total Number of normals: 262.  

 

Somatic mutations of SNAI2:

 

Generating mutation plots.

 

Highly correlated genes for SNAI2:

 

Showing top 20/507 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SNAI2LAMA30.80566610010
SNAI2INHBA0.794126808
SNAI2POLE40.789036505
SNAI2ITGA60.787264909
SNAI2WDR660.77981404
SNAI2CBX30.778158909
SNAI2COL5A20.764291909
SNAI2HOXD110.760881707
SNAI2TXNDC120.760632303
SNAI2FSCN10.756982908
SNAI2LRRC8D0.755363808
SNAI2CEP190.751278404
SNAI2TANK0.749374403
SNAI2KIF4A0.748663908
SNAI2TAF1A0.747441707
SNAI2ETV30.743187303
SNAI2PMEPA10.7297361009
SNAI2GALNS0.729641909
SNAI2MMP10.7287971009
SNAI2MFAP20.727884908

For details and further investigation, click here