| Full name: argonaute RISC catalytic component 2 | Alias Symbol: hAGO2|Q10|LINC00980 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 27161 | HGNC ID: HGNC:3263 | Ensembl Gene: ENSG00000123908 | OMIM ID: 606229 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of AGO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AGO2 | 27161 | 225827_at | 0.8148 | 0.1144 | |
| GSE26886 | AGO2 | 27161 | 225827_at | 1.0032 | 0.0001 | |
| GSE45670 | AGO2 | 27161 | 225827_at | 0.8278 | 0.0033 | |
| GSE53622 | AGO2 | 27161 | 82610 | 0.5077 | 0.0000 | |
| GSE53624 | AGO2 | 27161 | 82610 | 0.8248 | 0.0000 | |
| GSE63941 | AGO2 | 27161 | 225827_at | 1.5073 | 0.0243 | |
| GSE77861 | AGO2 | 27161 | 225827_at | 1.3011 | 0.0146 | |
| SRP007169 | AGO2 | 27161 | RNAseq | 0.8944 | 0.0028 | |
| SRP008496 | AGO2 | 27161 | RNAseq | 0.7968 | 0.0000 | |
| SRP064894 | AGO2 | 27161 | RNAseq | 0.3213 | 0.1563 | |
| SRP133303 | AGO2 | 27161 | RNAseq | 0.3559 | 0.0301 | |
| SRP159526 | AGO2 | 27161 | RNAseq | 0.6029 | 0.0857 | |
| SRP193095 | AGO2 | 27161 | RNAseq | 0.8483 | 0.0000 | |
| SRP219564 | AGO2 | 27161 | RNAseq | 0.0860 | 0.7889 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by AGO2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of AGO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AGO2 | 27161 | 16 | 0 | 14 | |
| GSE20123 | AGO2 | 27161 | 17 | 0 | 13 | |
| GSE43470 | AGO2 | 27161 | 22 | 2 | 19 | |
| GSE46452 | AGO2 | 27161 | 27 | 0 | 32 | |
| GSE47630 | AGO2 | 27161 | 24 | 0 | 16 | |
| GSE54993 | AGO2 | 27161 | 0 | 25 | 45 | |
| GSE54994 | AGO2 | 27161 | 39 | 1 | 13 | |
| GSE60625 | AGO2 | 27161 | 3 | 4 | 4 | |
| GSE74703 | AGO2 | 27161 | 19 | 1 | 16 | |
| GSE74704 | AGO2 | 27161 | 10 | 0 | 10 | |
| TCGA | AGO2 | 27161 | 65 | 2 | 29 |
Total number of gains: 242; Total number of losses: 35; Total Number of normals: 211.
Somatic mutations of AGO2:
Generating mutation plots.
Highly correlated genes for AGO2:
Showing top 20/1113 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AGO2 | C11orf95 | 0.811914 | 3 | 0 | 3 |
| AGO2 | PPP1R16A | 0.803562 | 3 | 0 | 3 |
| AGO2 | UBAP2L | 0.738899 | 4 | 0 | 4 |
| AGO2 | SLC25A32 | 0.734646 | 6 | 0 | 6 |
| AGO2 | IPO9 | 0.730881 | 5 | 0 | 5 |
| AGO2 | UBQLN4 | 0.725611 | 4 | 0 | 3 |
| AGO2 | FBRSL1 | 0.722169 | 4 | 0 | 4 |
| AGO2 | NOP14 | 0.720624 | 3 | 0 | 3 |
| AGO2 | MYH9 | 0.719876 | 3 | 0 | 3 |
| AGO2 | PTK2 | 0.719407 | 7 | 0 | 7 |
| AGO2 | PUF60 | 0.714775 | 7 | 0 | 7 |
| AGO2 | HSF1 | 0.714255 | 7 | 0 | 7 |
| AGO2 | PFDN2 | 0.713497 | 6 | 0 | 6 |
| AGO2 | TIGD5 | 0.711424 | 4 | 0 | 4 |
| AGO2 | MTERF3 | 0.709696 | 5 | 0 | 4 |
| AGO2 | ZNF593 | 0.704828 | 4 | 0 | 4 |
| AGO2 | TGS1 | 0.703595 | 4 | 0 | 4 |
| AGO2 | SERPINH1 | 0.700406 | 6 | 0 | 6 |
| AGO2 | KRTCAP2 | 0.6996 | 4 | 0 | 4 |
| AGO2 | TAF2 | 0.698111 | 7 | 0 | 7 |
For details and further investigation, click here
