| Full name: heat shock transcription factor 1 | Alias Symbol: HSTF1 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 3297 | HGNC ID: HGNC:5224 | Ensembl Gene: ENSG00000185122 | OMIM ID: 140580 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
HSF1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05134 | Legionellosis |
Expression of HSF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSF1 | 3297 | 202344_at | 0.8409 | 0.0647 | |
| GSE20347 | HSF1 | 3297 | 202344_at | 0.5783 | 0.0000 | |
| GSE23400 | HSF1 | 3297 | 202344_at | 0.4328 | 0.0000 | |
| GSE26886 | HSF1 | 3297 | 202344_at | 1.1264 | 0.0000 | |
| GSE29001 | HSF1 | 3297 | 202344_at | 0.3142 | 0.1723 | |
| GSE38129 | HSF1 | 3297 | 202344_at | 0.3992 | 0.0008 | |
| GSE45670 | HSF1 | 3297 | 202344_at | 0.3448 | 0.0187 | |
| GSE53622 | HSF1 | 3297 | 118348 | 0.4565 | 0.0000 | |
| GSE53624 | HSF1 | 3297 | 118348 | 0.7573 | 0.0000 | |
| GSE63941 | HSF1 | 3297 | 202344_at | 1.0386 | 0.0192 | |
| GSE77861 | HSF1 | 3297 | 202344_at | 0.5096 | 0.0084 | |
| GSE97050 | HSF1 | 3297 | A_23_P253841 | -0.0837 | 0.8333 | |
| SRP007169 | HSF1 | 3297 | RNAseq | 0.0489 | 0.8919 | |
| SRP008496 | HSF1 | 3297 | RNAseq | -0.0811 | 0.7296 | |
| SRP064894 | HSF1 | 3297 | RNAseq | 0.7830 | 0.0011 | |
| SRP133303 | HSF1 | 3297 | RNAseq | 0.5869 | 0.0005 | |
| SRP159526 | HSF1 | 3297 | RNAseq | 0.4619 | 0.0591 | |
| SRP193095 | HSF1 | 3297 | RNAseq | 0.7819 | 0.0000 | |
| SRP219564 | HSF1 | 3297 | RNAseq | 0.3950 | 0.3256 | |
| TCGA | HSF1 | 3297 | RNAseq | 0.1312 | 0.0078 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HSF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSF1 | 3297 | 17 | 1 | 12 | |
| GSE20123 | HSF1 | 3297 | 17 | 1 | 12 | |
| GSE43470 | HSF1 | 3297 | 16 | 2 | 25 | |
| GSE46452 | HSF1 | 3297 | 28 | 0 | 31 | |
| GSE47630 | HSF1 | 3297 | 25 | 1 | 14 | |
| GSE54993 | HSF1 | 3297 | 0 | 25 | 45 | |
| GSE54994 | HSF1 | 3297 | 39 | 1 | 13 | |
| GSE60625 | HSF1 | 3297 | 3 | 4 | 4 | |
| GSE74703 | HSF1 | 3297 | 14 | 1 | 21 | |
| GSE74704 | HSF1 | 3297 | 10 | 0 | 10 | |
| TCGA | HSF1 | 3297 | 63 | 2 | 31 |
Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.
Somatic mutations of HSF1:
Generating mutation plots.
Highly correlated genes for HSF1:
Showing top 20/1158 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSF1 | SLC39A3 | 0.786316 | 3 | 0 | 3 |
| HSF1 | ZC3H3 | 0.744694 | 11 | 0 | 11 |
| HSF1 | TIGD5 | 0.740405 | 6 | 0 | 5 |
| HSF1 | PUF60 | 0.733102 | 11 | 0 | 10 |
| HSF1 | CRTC2 | 0.733001 | 5 | 0 | 4 |
| HSF1 | ALKBH6 | 0.729669 | 4 | 0 | 4 |
| HSF1 | GOLM1 | 0.728315 | 3 | 0 | 3 |
| HSF1 | TP53I13 | 0.721378 | 5 | 0 | 5 |
| HSF1 | RTKN | 0.719456 | 6 | 0 | 6 |
| HSF1 | SLC52A2 | 0.717694 | 11 | 0 | 10 |
| HSF1 | AGO2 | 0.714255 | 7 | 0 | 7 |
| HSF1 | COLGALT1 | 0.705668 | 8 | 0 | 7 |
| HSF1 | ANKRD52 | 0.697041 | 5 | 0 | 5 |
| HSF1 | WDR81 | 0.696232 | 3 | 0 | 3 |
| HSF1 | C4orf48 | 0.690892 | 6 | 0 | 6 |
| HSF1 | NACC1 | 0.688475 | 4 | 0 | 4 |
| HSF1 | MAF1 | 0.681885 | 9 | 0 | 7 |
| HSF1 | CD276 | 0.681811 | 4 | 0 | 4 |
| HSF1 | SPATA17 | 0.68067 | 3 | 0 | 3 |
| HSF1 | MARK4 | 0.679816 | 4 | 0 | 3 |
For details and further investigation, click here
