PTK2

 

Full name: protein tyrosine kinase 2 Alias Symbol: FAK|FADK|FAK1|PPP1R71
Type: protein-coding gene Cytoband: 8q24.3
Entrez ID: 5747 HGNC ID: HGNC:9611 Ensembl Gene: ENSG00000169398 OMIM ID: 600758
Drug and gene relationship at DGIdb
Screen Evidence:

 

PTK2 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05222Small cell lung cancer

 

Expression of PTK2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PTK2 5747 208820_at 0.9058 0.0672
GSE20347 PTK2 5747 208820_at 1.0951 0.0000
GSE23400 PTK2 5747 208820_at 1.0392 0.0000
GSE26886 PTK2 5747 208820_at 1.6248 0.0000
GSE29001 PTK2 5747 208820_at 0.9676 0.0002
GSE38129 PTK2 5747 208820_at 0.8161 0.0000
GSE45670 PTK2 5747 208820_at 0.5495 0.0427
GSE53622 PTK2 5747 45888 1.0039 0.0000
GSE53624 PTK2 5747 45888 0.9590 0.0000
GSE63941 PTK2 5747 208820_at 0.3871 0.3778
GSE77861 PTK2 5747 208820_at 1.1041 0.0049
GSE97050 PTK2 5747 A_23_P22096 0.7761 0.0599
SRP007169 PTK2 5747 RNAseq 0.2708 0.4381
SRP008496 PTK2 5747 RNAseq 0.8863 0.0016
SRP064894 PTK2 5747 RNAseq 0.7902 0.0000
SRP133303 PTK2 5747 RNAseq 0.8221 0.0000
SRP159526 PTK2 5747 RNAseq 0.7463 0.0006
SRP193095 PTK2 5747 RNAseq 0.7840 0.0000
SRP219564 PTK2 5747 RNAseq 0.7227 0.0161
TCGA PTK2 5747 RNAseq 0.0720 0.1119

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by PTK2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PTK2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PTK2 5747 17 0 13
GSE20123 PTK2 5747 17 0 13
GSE43470 PTK2 5747 22 2 19
GSE46452 PTK2 5747 27 0 32
GSE47630 PTK2 5747 24 0 16
GSE54993 PTK2 5747 0 26 44
GSE54994 PTK2 5747 39 1 13
GSE60625 PTK2 5747 3 4 4
GSE74703 PTK2 5747 19 1 16
GSE74704 PTK2 5747 10 0 10
TCGA PTK2 5747 65 2 29

Total number of gains: 243; Total number of losses: 36; Total Number of normals: 209.  

 

Somatic mutations of PTK2:

 

Generating mutation plots.

 

Highly correlated genes for PTK2:

 

Showing top 20/2319 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PTK2STK30.8328711011
PTK2CMTM40.820568303
PTK2MTERF30.816854808
PTK2ATP11C0.812372303
PTK2HNRNPUL10.806373303
PTK2PKIG0.798438303
PTK2IMMP1L0.783972303
PTK2SSBP40.783188505
PTK2LAPTM4B0.78061311011
PTK2KRTCAP20.779739505
PTK2PLXNA10.77909411011
PTK2FNDC3B0.77546411011
PTK2CCDC1270.774416303
PTK2WDR540.77426606
PTK2ZNF7070.77264303
PTK2C20orf1940.766887303
PTK2UBQLN40.766706404
PTK2SLC39A30.766224404
PTK2ACBD60.763107605
PTK2INTS30.760077404

For details and further investigation, click here