MYH9

 

Full name: myosin heavy chain 9 Alias Symbol: NMMHCA|NMHC-II-A|MHA|FTNS|EPSTS
Type: protein-coding gene Cytoband: 22q12.3
Entrez ID: 4627 HGNC ID: HGNC:7579 Ensembl Gene: ENSG00000100345 OMIM ID: 160775
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 127/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MYH9 involved pathways:

KEGG pathway Description View
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
hsa05132Salmonella infection

 

Expression of MYH9:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MYH9 4627 211926_s_at 0.5664 0.2281
GSE20347 MYH9 4627 211926_s_at 0.5833 0.0032
GSE23400 MYH9 4627 211926_s_at 0.7203 0.0000
GSE26886 MYH9 4627 211926_s_at 1.3258 0.0000
GSE29001 MYH9 4627 211926_s_at 0.5319 0.0334
GSE38129 MYH9 4627 211926_s_at 0.6880 0.0000
GSE45670 MYH9 4627 211926_s_at 0.7117 0.0005
GSE53622 MYH9 4627 43265 0.1115 0.1577
GSE53624 MYH9 4627 43265 0.0133 0.8544
GSE63941 MYH9 4627 211926_s_at -0.4393 0.5189
GSE77861 MYH9 4627 211926_s_at 1.2496 0.0066
GSE97050 MYH9 4627 A_33_P3353692 -0.8419 0.2525
SRP007169 MYH9 4627 RNAseq 3.0742 0.0000
SRP008496 MYH9 4627 RNAseq 2.7024 0.0000
SRP064894 MYH9 4627 RNAseq 0.9474 0.0001
SRP133303 MYH9 4627 RNAseq 0.7495 0.0013
SRP159526 MYH9 4627 RNAseq 0.4522 0.0251
SRP193095 MYH9 4627 RNAseq 1.0202 0.0000
SRP219564 MYH9 4627 RNAseq 0.5958 0.1534
TCGA MYH9 4627 RNAseq 0.1148 0.0055

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by MYH9 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MYH9:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MYH9 4627 6 6 18
GSE20123 MYH9 4627 6 5 19
GSE43470 MYH9 4627 4 6 33
GSE46452 MYH9 4627 31 1 27
GSE47630 MYH9 4627 8 5 27
GSE54993 MYH9 4627 3 6 61
GSE54994 MYH9 4627 9 9 35
GSE60625 MYH9 4627 5 0 6
GSE74703 MYH9 4627 4 4 28
GSE74704 MYH9 4627 3 2 15
TCGA MYH9 4627 27 15 54

Total number of gains: 106; Total number of losses: 59; Total Number of normals: 323.  

 

Somatic mutations of MYH9:

 

Generating mutation plots.

 

Highly correlated genes for MYH9:

 

Showing top 20/807 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MYH9WDR540.882066404
MYH9XPR10.851945404
MYH9POLE40.796879404
MYH9SPRR2G0.787699303
MYH9GTF2IRD20.786311303
MYH9ALOXE30.749143303
MYH9TENM20.744233404
MYH9DLX40.740186303
MYH9YDJC0.735656303
MYH9NTMT10.728984404
MYH9TTYH30.721494504
MYH9GALNT180.721079504
MYH9AGO20.719876303
MYH9CKAP50.719698808
MYH9HOMER30.7131951009
MYH9ITM2C0.705168303
MYH9BLACAT10.704512404
MYH9EMC100.704244303
MYH9SHISA20.700401404
MYH9PES10.697501807

For details and further investigation, click here