ALB

 

Full name: albumin Alias Symbol: 
Type: protein-coding gene Cytoband: 4q13.3
Entrez ID: 213 HGNC ID: HGNC:399 Ensembl Gene: ENSG00000163631 OMIM ID: 103600
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ALB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ALB 213 214842_s_at -0.0396 0.8928
GSE20347 ALB 213 214837_at -0.0606 0.2869
GSE23400 ALB 213 214842_s_at -0.1117 0.0084
GSE26886 ALB 213 214837_at -0.0804 0.3704
GSE29001 ALB 213 214842_s_at -0.0311 0.9003
GSE38129 ALB 213 214837_at -0.0910 0.0916
GSE45670 ALB 213 214837_at 0.1176 0.1511
GSE53622 ALB 213 80513 0.0523 0.8197
GSE53624 ALB 213 80513 -0.1011 0.7076
GSE63941 ALB 213 214842_s_at 0.0840 0.6450
GSE77861 ALB 213 214842_s_at 0.0237 0.8414
TCGA ALB 213 RNAseq -3.0890 0.0003

Upregulated datasets: 0; Downregulated datasets: 1.  


 

Survival by ALB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of ALB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ALB 213 2 9 19
GSE20123 ALB 213 2 9 19
GSE43470 ALB 213 0 13 30
GSE46452 ALB 213 3 34 22
GSE47630 ALB 213 1 19 20
GSE54993 ALB 213 7 0 63
GSE54994 ALB 213 1 9 43
GSE60625 ALB 213 0 0 11
GSE74703 ALB 213 0 11 25
GSE74704 ALB 213 2 5 13
TCGA ALB 213 19 27 50

Total number of gains: 37; Total number of losses: 136; Total Number of normals: 315.  


 

Somatic mutations of ALB:

 

Generating mutation plots.

 

Highly correlated genes for ALB:

 

Showing top 20/386 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ALBGREB1L0.678539303
ALBFCN20.677561303
ALBOR10C10.665555303
ALBIL1RAPL20.665079403
ALBPKLR0.657793303
ALBSLC24A20.656301404
ALBNXPE40.653011403
ALBTCP10L0.652434505
ALBS100G0.65184505
ALBGPR1820.650687303
ALBTECTA0.650654303
ALBADCYAP10.646969303
ALBLGR50.645859403
ALBNEUROD60.642035303
ALBKRT380.638846403
ALBNEU30.638514505
ALBSLC6A50.637848403
ALBRPS6KA60.63444404
ALBSMCP0.631215505
ALBODF10.629333504

For details and further investigation, click here