| Full name: adenylate cyclase activating polypeptide 1 | Alias Symbol: PACAP | ||
| Type: protein-coding gene | Cytoband: 18p11.32 | ||
| Entrez ID: 116 | HGNC ID: HGNC:241 | Ensembl Gene: ENSG00000141433 | OMIM ID: 102980 |
| Drug and gene relationship at DGIdb | |||
ADCYAP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04911 | Insulin secretion | |
| hsa04924 | Renin secretion |
Expression of ADCYAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADCYAP1 | 116 | 230237_at | -0.6388 | 0.6439 | |
| GSE20347 | ADCYAP1 | 116 | 206281_at | -0.0303 | 0.6773 | |
| GSE23400 | ADCYAP1 | 116 | 206281_at | -0.1987 | 0.0000 | |
| GSE26886 | ADCYAP1 | 116 | 206281_at | -0.1342 | 0.1562 | |
| GSE29001 | ADCYAP1 | 116 | 206281_at | -0.1441 | 0.5713 | |
| GSE38129 | ADCYAP1 | 116 | 206281_at | -0.1654 | 0.0258 | |
| GSE45670 | ADCYAP1 | 116 | 230237_at | 0.1476 | 0.7105 | |
| GSE53622 | ADCYAP1 | 116 | 112724 | -1.6808 | 0.0000 | |
| GSE53624 | ADCYAP1 | 116 | 112724 | -0.9539 | 0.0062 | |
| GSE63941 | ADCYAP1 | 116 | 230237_at | 0.0793 | 0.6031 | |
| GSE77861 | ADCYAP1 | 116 | 206281_at | -0.0319 | 0.8197 | |
| GSE97050 | ADCYAP1 | 116 | A_33_P3392092 | -0.0044 | 0.9939 | |
| SRP159526 | ADCYAP1 | 116 | RNAseq | 1.2566 | 0.0233 | |
| TCGA | ADCYAP1 | 116 | RNAseq | -1.6191 | 0.0004 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by ADCYAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADCYAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADCYAP1 | 116 | 6 | 3 | 21 | |
| GSE20123 | ADCYAP1 | 116 | 6 | 3 | 21 | |
| GSE43470 | ADCYAP1 | 116 | 2 | 4 | 37 | |
| GSE46452 | ADCYAP1 | 116 | 4 | 20 | 35 | |
| GSE47630 | ADCYAP1 | 116 | 7 | 18 | 15 | |
| GSE54993 | ADCYAP1 | 116 | 6 | 3 | 61 | |
| GSE54994 | ADCYAP1 | 116 | 11 | 8 | 34 | |
| GSE60625 | ADCYAP1 | 116 | 0 | 4 | 7 | |
| GSE74703 | ADCYAP1 | 116 | 2 | 2 | 32 | |
| GSE74704 | ADCYAP1 | 116 | 4 | 2 | 14 | |
| TCGA | ADCYAP1 | 116 | 35 | 18 | 43 |
Total number of gains: 83; Total number of losses: 85; Total Number of normals: 320.
Somatic mutations of ADCYAP1:
Generating mutation plots.
Highly correlated genes for ADCYAP1:
Showing top 20/608 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADCYAP1 | GPRIN3 | 0.763759 | 3 | 0 | 3 |
| ADCYAP1 | DDX4 | 0.748074 | 3 | 0 | 3 |
| ADCYAP1 | HTR1A | 0.741891 | 3 | 0 | 3 |
| ADCYAP1 | CNTF | 0.738788 | 3 | 0 | 3 |
| ADCYAP1 | DOC2B | 0.734173 | 4 | 0 | 4 |
| ADCYAP1 | CD163L1 | 0.73326 | 4 | 0 | 4 |
| ADCYAP1 | MBTPS2 | 0.72399 | 3 | 0 | 3 |
| ADCYAP1 | DNMT3L | 0.71909 | 3 | 0 | 3 |
| ADCYAP1 | LGALS14 | 0.717494 | 3 | 0 | 3 |
| ADCYAP1 | BSN | 0.714001 | 3 | 0 | 3 |
| ADCYAP1 | GNRHR | 0.710935 | 4 | 0 | 4 |
| ADCYAP1 | KCNA4 | 0.709076 | 3 | 0 | 3 |
| ADCYAP1 | MTAP | 0.707244 | 4 | 0 | 3 |
| ADCYAP1 | NAGLU | 0.706093 | 3 | 0 | 3 |
| ADCYAP1 | EPX | 0.705013 | 3 | 0 | 3 |
| ADCYAP1 | GTPBP2 | 0.704214 | 3 | 0 | 3 |
| ADCYAP1 | RNF185-AS1 | 0.700571 | 3 | 0 | 3 |
| ADCYAP1 | KIR2DS4 | 0.695474 | 3 | 0 | 3 |
| ADCYAP1 | ZNF619 | 0.695385 | 3 | 0 | 3 |
| ADCYAP1 | HEYL | 0.691795 | 3 | 0 | 3 |
For details and further investigation, click here
