| Full name: leucine rich repeat containing G protein-coupled receptor 5 | Alias Symbol: HG38|FEX | ||
| Type: protein-coding gene | Cytoband: 12q21.1 | ||
| Entrez ID: 8549 | HGNC ID: HGNC:4504 | Ensembl Gene: ENSG00000139292 | OMIM ID: 606667 |
| Drug and gene relationship at DGIdb | |||
Expression of LGR5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LGR5 | 8549 | 210393_at | -0.0854 | 0.7364 | |
| GSE20347 | LGR5 | 8549 | 210393_at | 0.0863 | 0.4435 | |
| GSE23400 | LGR5 | 8549 | 210393_at | -0.1249 | 0.0246 | |
| GSE26886 | LGR5 | 8549 | 210393_at | -0.0637 | 0.5719 | |
| GSE29001 | LGR5 | 8549 | 210393_at | -0.1162 | 0.5780 | |
| GSE38129 | LGR5 | 8549 | 210393_at | -0.1114 | 0.3702 | |
| GSE45670 | LGR5 | 8549 | 210393_at | 0.0435 | 0.7969 | |
| GSE53622 | LGR5 | 8549 | 22391 | 2.7406 | 0.0000 | |
| GSE53624 | LGR5 | 8549 | 111292 | 3.0085 | 0.0000 | |
| GSE63941 | LGR5 | 8549 | 210393_at | -0.0495 | 0.7920 | |
| GSE77861 | LGR5 | 8549 | 210393_at | -0.0302 | 0.7871 | |
| GSE97050 | LGR5 | 8549 | A_23_P98974 | 1.3819 | 0.2460 | |
| SRP133303 | LGR5 | 8549 | RNAseq | 4.7942 | 0.0000 | |
| TCGA | LGR5 | 8549 | RNAseq | 0.2884 | 0.5114 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by LGR5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LGR5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LGR5 | 8549 | 4 | 3 | 23 | |
| GSE20123 | LGR5 | 8549 | 4 | 3 | 23 | |
| GSE43470 | LGR5 | 8549 | 4 | 0 | 39 | |
| GSE46452 | LGR5 | 8549 | 8 | 1 | 50 | |
| GSE47630 | LGR5 | 8549 | 10 | 1 | 29 | |
| GSE54993 | LGR5 | 8549 | 0 | 5 | 65 | |
| GSE54994 | LGR5 | 8549 | 8 | 1 | 44 | |
| GSE60625 | LGR5 | 8549 | 0 | 0 | 11 | |
| GSE74703 | LGR5 | 8549 | 4 | 0 | 32 | |
| GSE74704 | LGR5 | 8549 | 3 | 2 | 15 | |
| TCGA | LGR5 | 8549 | 22 | 9 | 65 |
Total number of gains: 67; Total number of losses: 25; Total Number of normals: 396.
Somatic mutations of LGR5:
Generating mutation plots.
Highly correlated genes for LGR5:
Showing top 20/480 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LGR5 | ADRB3 | 0.714218 | 3 | 0 | 3 |
| LGR5 | OR12D2 | 0.713699 | 3 | 0 | 3 |
| LGR5 | RHAG | 0.711458 | 3 | 0 | 3 |
| LGR5 | BCAN | 0.708472 | 5 | 0 | 4 |
| LGR5 | CPN1 | 0.700933 | 3 | 0 | 3 |
| LGR5 | ATG10 | 0.694002 | 5 | 0 | 5 |
| LGR5 | C5AR2 | 0.690758 | 3 | 0 | 3 |
| LGR5 | EPS8L3 | 0.689726 | 3 | 0 | 3 |
| LGR5 | HAND1 | 0.681364 | 4 | 0 | 4 |
| LGR5 | CCDC30 | 0.677374 | 5 | 0 | 4 |
| LGR5 | GPLD1 | 0.675144 | 3 | 0 | 3 |
| LGR5 | KRTAP5-8 | 0.670703 | 5 | 0 | 5 |
| LGR5 | FGF16 | 0.668548 | 4 | 0 | 4 |
| LGR5 | MYL1 | 0.666615 | 4 | 0 | 3 |
| LGR5 | CACNG3 | 0.666329 | 3 | 0 | 3 |
| LGR5 | NR5A1 | 0.662643 | 3 | 0 | 3 |
| LGR5 | FRMPD1 | 0.66054 | 4 | 0 | 4 |
| LGR5 | GLP1R | 0.660135 | 5 | 0 | 5 |
| LGR5 | ODF1 | 0.654562 | 4 | 0 | 4 |
| LGR5 | MC2R | 0.653456 | 4 | 0 | 3 |
For details and further investigation, click here
