| Full name: aldehyde dehydrogenase 1 family member A1 | Alias Symbol: RALDH1 | ||
| Type: protein-coding gene | Cytoband: 9q21.13 | ||
| Entrez ID: 216 | HGNC ID: HGNC:402 | Ensembl Gene: ENSG00000165092 | OMIM ID: 100640 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ALDH1A1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALDH1A1 | 216 | 212224_at | -1.9323 | 0.3570 | |
| GSE20347 | ALDH1A1 | 216 | 212224_at | 0.4377 | 0.5667 | |
| GSE23400 | ALDH1A1 | 216 | 212224_at | -0.0231 | 0.9501 | |
| GSE26886 | ALDH1A1 | 216 | 212224_at | -0.9585 | 0.2759 | |
| GSE29001 | ALDH1A1 | 216 | 212224_at | -0.1334 | 0.8920 | |
| GSE38129 | ALDH1A1 | 216 | 212224_at | -0.0879 | 0.8970 | |
| GSE45670 | ALDH1A1 | 216 | 212224_at | -1.6952 | 0.1496 | |
| GSE53622 | ALDH1A1 | 216 | 120315 | -1.0350 | 0.0003 | |
| GSE53624 | ALDH1A1 | 216 | 120315 | -0.9569 | 0.0000 | |
| GSE63941 | ALDH1A1 | 216 | 212224_at | -4.0286 | 0.1098 | |
| GSE77861 | ALDH1A1 | 216 | 212224_at | 1.4203 | 0.3476 | |
| GSE97050 | ALDH1A1 | 216 | A_23_P83098 | -0.7152 | 0.1725 | |
| SRP007169 | ALDH1A1 | 216 | RNAseq | 2.5820 | 0.0007 | |
| SRP008496 | ALDH1A1 | 216 | RNAseq | 2.4312 | 0.0013 | |
| SRP064894 | ALDH1A1 | 216 | RNAseq | -0.4031 | 0.3737 | |
| SRP133303 | ALDH1A1 | 216 | RNAseq | -0.2874 | 0.5993 | |
| SRP159526 | ALDH1A1 | 216 | RNAseq | 1.3372 | 0.0311 | |
| SRP193095 | ALDH1A1 | 216 | RNAseq | -1.2466 | 0.0109 | |
| SRP219564 | ALDH1A1 | 216 | RNAseq | -0.5240 | 0.4579 | |
| TCGA | ALDH1A1 | 216 | RNAseq | -0.9043 | 0.0009 |
Upregulated datasets: 3; Downregulated datasets: 2.
Survival by ALDH1A1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALDH1A1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALDH1A1 | 216 | 6 | 10 | 14 | |
| GSE20123 | ALDH1A1 | 216 | 6 | 10 | 14 | |
| GSE43470 | ALDH1A1 | 216 | 6 | 5 | 32 | |
| GSE46452 | ALDH1A1 | 216 | 6 | 14 | 39 | |
| GSE47630 | ALDH1A1 | 216 | 1 | 18 | 21 | |
| GSE54993 | ALDH1A1 | 216 | 4 | 1 | 65 | |
| GSE54994 | ALDH1A1 | 216 | 4 | 13 | 36 | |
| GSE60625 | ALDH1A1 | 216 | 0 | 0 | 11 | |
| GSE74703 | ALDH1A1 | 216 | 5 | 4 | 27 | |
| GSE74704 | ALDH1A1 | 216 | 3 | 8 | 9 | |
| TCGA | ALDH1A1 | 216 | 19 | 27 | 50 |
Total number of gains: 60; Total number of losses: 110; Total Number of normals: 318.
Somatic mutations of ALDH1A1:
Generating mutation plots.
Highly correlated genes for ALDH1A1:
Showing top 20/206 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALDH1A1 | MMRN2 | 0.769484 | 3 | 0 | 3 |
| ALDH1A1 | PNKD | 0.732062 | 3 | 0 | 3 |
| ALDH1A1 | TSR2 | 0.723227 | 3 | 0 | 3 |
| ALDH1A1 | ZNF829 | 0.711743 | 3 | 0 | 3 |
| ALDH1A1 | VPS39 | 0.710848 | 3 | 0 | 3 |
| ALDH1A1 | TTC19 | 0.696251 | 4 | 0 | 3 |
| ALDH1A1 | ZFR | 0.684944 | 3 | 0 | 3 |
| ALDH1A1 | TRAPPC8 | 0.67132 | 3 | 0 | 3 |
| ALDH1A1 | KIF9 | 0.66805 | 3 | 0 | 3 |
| ALDH1A1 | IMPACT | 0.655243 | 3 | 0 | 3 |
| ALDH1A1 | IFT88 | 0.652699 | 3 | 0 | 3 |
| ALDH1A1 | TSHZ1 | 0.647488 | 4 | 0 | 3 |
| ALDH1A1 | EID1 | 0.63928 | 4 | 0 | 3 |
| ALDH1A1 | ZNF784 | 0.639108 | 3 | 0 | 3 |
| ALDH1A1 | ZNF566 | 0.634368 | 3 | 0 | 3 |
| ALDH1A1 | ZNF3 | 0.634143 | 3 | 0 | 3 |
| ALDH1A1 | THAP4 | 0.634088 | 4 | 0 | 4 |
| ALDH1A1 | KAT7 | 0.632467 | 4 | 0 | 3 |
| ALDH1A1 | VAMP1 | 0.630427 | 4 | 0 | 3 |
| ALDH1A1 | COMMD3 | 0.628766 | 4 | 0 | 4 |
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