| Full name: VPS39 subunit of HOPS complex | Alias Symbol: KIAA0770|VAM6 | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 23339 | HGNC ID: HGNC:20593 | Ensembl Gene: ENSG00000166887 | OMIM ID: 612188 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VPS39:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS39 | 23339 | 212156_at | -0.0836 | 0.8561 | |
| GSE20347 | VPS39 | 23339 | 212156_at | 0.1028 | 0.1510 | |
| GSE23400 | VPS39 | 23339 | 212156_at | -0.0077 | 0.8897 | |
| GSE26886 | VPS39 | 23339 | 212156_at | -0.4502 | 0.0176 | |
| GSE29001 | VPS39 | 23339 | 212156_at | 0.0729 | 0.8040 | |
| GSE38129 | VPS39 | 23339 | 212156_at | -0.0304 | 0.7578 | |
| GSE45670 | VPS39 | 23339 | 212156_at | 0.0364 | 0.7481 | |
| GSE53622 | VPS39 | 23339 | 85122 | -0.0451 | 0.4993 | |
| GSE53624 | VPS39 | 23339 | 85122 | 0.0467 | 0.4653 | |
| GSE63941 | VPS39 | 23339 | 212156_at | -0.1928 | 0.5723 | |
| GSE77861 | VPS39 | 23339 | 212156_at | 0.1974 | 0.1396 | |
| GSE97050 | VPS39 | 23339 | A_24_P167825 | -0.3769 | 0.1938 | |
| SRP007169 | VPS39 | 23339 | RNAseq | -0.1129 | 0.7008 | |
| SRP008496 | VPS39 | 23339 | RNAseq | -0.2973 | 0.1980 | |
| SRP064894 | VPS39 | 23339 | RNAseq | -0.0329 | 0.7537 | |
| SRP133303 | VPS39 | 23339 | RNAseq | -0.0235 | 0.8286 | |
| SRP159526 | VPS39 | 23339 | RNAseq | -0.3044 | 0.1282 | |
| SRP193095 | VPS39 | 23339 | RNAseq | 0.0005 | 0.9957 | |
| SRP219564 | VPS39 | 23339 | RNAseq | -0.2611 | 0.3975 | |
| TCGA | VPS39 | 23339 | RNAseq | -0.1498 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VPS39 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS39:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS39 | 23339 | 4 | 5 | 21 | |
| GSE20123 | VPS39 | 23339 | 4 | 6 | 20 | |
| GSE43470 | VPS39 | 23339 | 4 | 5 | 34 | |
| GSE46452 | VPS39 | 23339 | 3 | 7 | 49 | |
| GSE47630 | VPS39 | 23339 | 8 | 11 | 21 | |
| GSE54993 | VPS39 | 23339 | 4 | 6 | 60 | |
| GSE54994 | VPS39 | 23339 | 5 | 7 | 41 | |
| GSE60625 | VPS39 | 23339 | 4 | 0 | 7 | |
| GSE74703 | VPS39 | 23339 | 4 | 4 | 28 | |
| GSE74704 | VPS39 | 23339 | 3 | 3 | 14 | |
| TCGA | VPS39 | 23339 | 11 | 18 | 67 |
Total number of gains: 54; Total number of losses: 72; Total Number of normals: 362.
Somatic mutations of VPS39:
Generating mutation plots.
Highly correlated genes for VPS39:
Showing top 20/263 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS39 | LMO4 | 0.775027 | 3 | 0 | 3 |
| VPS39 | CXorf40B | 0.764651 | 3 | 0 | 3 |
| VPS39 | ORAI3 | 0.740002 | 3 | 0 | 3 |
| VPS39 | ALDOC | 0.739833 | 3 | 0 | 3 |
| VPS39 | WLS | 0.733691 | 3 | 0 | 3 |
| VPS39 | FLNB | 0.723153 | 3 | 0 | 3 |
| VPS39 | TTBK2 | 0.712423 | 5 | 0 | 5 |
| VPS39 | ALDH1A1 | 0.710848 | 3 | 0 | 3 |
| VPS39 | ABHD2 | 0.705714 | 3 | 0 | 3 |
| VPS39 | CDKN2D | 0.705703 | 3 | 0 | 3 |
| VPS39 | ZNF784 | 0.705151 | 4 | 0 | 3 |
| VPS39 | ARF3 | 0.703432 | 3 | 0 | 3 |
| VPS39 | DOCK8 | 0.700961 | 3 | 0 | 3 |
| VPS39 | FAM120B | 0.698509 | 3 | 0 | 3 |
| VPS39 | NPLOC4 | 0.69433 | 5 | 0 | 4 |
| VPS39 | NDUFAF1 | 0.693809 | 3 | 0 | 3 |
| VPS39 | MYEF2 | 0.686894 | 3 | 0 | 3 |
| VPS39 | PLCB4 | 0.684915 | 3 | 0 | 3 |
| VPS39 | DLG5 | 0.68352 | 3 | 0 | 3 |
| VPS39 | HSPB6 | 0.681828 | 3 | 0 | 3 |
For details and further investigation, click here
