| Full name: COMM domain containing 3 | Alias Symbol: BUP | ||
| Type: protein-coding gene | Cytoband: 10p12.2 | ||
| Entrez ID: 23412 | HGNC ID: HGNC:23332 | Ensembl Gene: ENSG00000148444 | OMIM ID: 616700 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COMMD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COMMD3 | 23412 | 218048_at | -0.0261 | 0.9361 | |
| GSE20347 | COMMD3 | 23412 | 218048_at | -0.1444 | 0.2856 | |
| GSE23400 | COMMD3 | 23412 | 218048_at | -0.0192 | 0.7551 | |
| GSE26886 | COMMD3 | 23412 | 218048_at | 0.0735 | 0.7182 | |
| GSE29001 | COMMD3 | 23412 | 218048_at | -0.1354 | 0.6758 | |
| GSE38129 | COMMD3 | 23412 | 218048_at | -0.1579 | 0.1566 | |
| GSE45670 | COMMD3 | 23412 | 218048_at | -0.1679 | 0.2492 | |
| GSE53622 | COMMD3 | 23412 | 37813 | -0.1988 | 0.0054 | |
| GSE53624 | COMMD3 | 23412 | 37813 | -0.1757 | 0.0020 | |
| GSE63941 | COMMD3 | 23412 | 218048_at | -0.2624 | 0.5343 | |
| GSE77861 | COMMD3 | 23412 | 218048_at | -0.4439 | 0.0389 | |
| GSE97050 | COMMD3 | 23412 | A_23_P138514 | 0.2928 | 0.2349 | |
| SRP007169 | COMMD3 | 23412 | RNAseq | -0.7830 | 0.0393 | |
| SRP008496 | COMMD3 | 23412 | RNAseq | -0.7433 | 0.0002 | |
| SRP064894 | COMMD3 | 23412 | RNAseq | -0.1142 | 0.5744 | |
| SRP133303 | COMMD3 | 23412 | RNAseq | -0.1988 | 0.2143 | |
| SRP159526 | COMMD3 | 23412 | RNAseq | -0.4828 | 0.0509 | |
| SRP193095 | COMMD3 | 23412 | RNAseq | -0.6362 | 0.0000 | |
| SRP219564 | COMMD3 | 23412 | RNAseq | -0.6298 | 0.0124 | |
| TCGA | COMMD3 | 23412 | RNAseq | 0.0344 | 0.5482 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COMMD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COMMD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COMMD3 | 23412 | 5 | 8 | 17 | |
| GSE20123 | COMMD3 | 23412 | 5 | 7 | 18 | |
| GSE43470 | COMMD3 | 23412 | 4 | 4 | 35 | |
| GSE46452 | COMMD3 | 23412 | 1 | 14 | 44 | |
| GSE47630 | COMMD3 | 23412 | 5 | 15 | 20 | |
| GSE54993 | COMMD3 | 23412 | 10 | 0 | 60 | |
| GSE54994 | COMMD3 | 23412 | 3 | 9 | 41 | |
| GSE60625 | COMMD3 | 23412 | 0 | 0 | 11 | |
| GSE74703 | COMMD3 | 23412 | 3 | 2 | 31 | |
| GSE74704 | COMMD3 | 23412 | 0 | 6 | 14 | |
| TCGA | COMMD3 | 23412 | 18 | 25 | 53 |
Total number of gains: 54; Total number of losses: 90; Total Number of normals: 344.
Somatic mutations of COMMD3:
Generating mutation plots.
Highly correlated genes for COMMD3:
Showing top 20/367 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COMMD3 | CTDSP2 | 0.783156 | 3 | 0 | 3 |
| COMMD3 | SMARCA5 | 0.769843 | 3 | 0 | 3 |
| COMMD3 | FMR1 | 0.746107 | 3 | 0 | 3 |
| COMMD3 | RBL2 | 0.724091 | 4 | 0 | 3 |
| COMMD3 | MTUS1 | 0.715876 | 3 | 0 | 3 |
| COMMD3 | NFKB1 | 0.711676 | 5 | 0 | 5 |
| COMMD3 | MSRB3 | 0.70874 | 3 | 0 | 3 |
| COMMD3 | NDUFA7 | 0.708336 | 4 | 0 | 4 |
| COMMD3 | RNF125 | 0.698238 | 3 | 0 | 3 |
| COMMD3 | FITM2 | 0.697965 | 3 | 0 | 3 |
| COMMD3 | TRIM22 | 0.695474 | 3 | 0 | 3 |
| COMMD3 | KBTBD4 | 0.695148 | 5 | 0 | 4 |
| COMMD3 | PTRHD1 | 0.694734 | 4 | 0 | 3 |
| COMMD3 | AFF3 | 0.694517 | 3 | 0 | 3 |
| COMMD3 | POLR2C | 0.692341 | 3 | 0 | 3 |
| COMMD3 | EPS8 | 0.690266 | 4 | 0 | 3 |
| COMMD3 | ZNF548 | 0.687497 | 3 | 0 | 3 |
| COMMD3 | ANKRD13A | 0.687419 | 3 | 0 | 3 |
| COMMD3 | RAP1GDS1 | 0.681915 | 3 | 0 | 3 |
| COMMD3 | MAP2K5 | 0.678561 | 4 | 0 | 3 |
For details and further investigation, click here
